5WYX
| Crystal structure of human TLR8 in complex with CU-CPT8m | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(3-methylphenyl)pyrazolo[1,5-a]pyrimidine-3-carboxamide, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2017-01-16 | 公開日 | 2017-12-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Small-molecule inhibition of TLR8 through stabilization of its resting state Nat. Chem. Biol., 14, 2018
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5WYZ
| Crystal structure of human TLR8 in complex with CU-CPT9b | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2017-01-16 | 公開日 | 2017-12-13 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Small-molecule inhibition of TLR8 through stabilization of its resting state Nat. Chem. Biol., 14, 2018
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5Z15
| Crystal structure of human TLR8 in complex with CU-CPT9c | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(7-chloranylquinolin-4-yl)-2-methyl-phenol, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2017-12-25 | 公開日 | 2018-07-04 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Inhibition of Toll-like Receptor 8 by Specifically Targeting a Unique Allosteric Site and Locking Its Resting State To Be Published
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3WN4
| Crystal structure of human TLR8 in complex with DS-877 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-butylfuro[2,3-c]quinolin-4-amine, Toll-like receptor 8, ... | 著者 | Tanji, H, Ohto, U, Shimizu, T. | 登録日 | 2013-12-02 | 公開日 | 2014-02-19 | 最終更新日 | 2022-08-24 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Structure-based design of novel human Toll-like receptor 8 agonists. Chemmedchem, 9, 2014
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7AIR
| Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 2) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC) | 登録日 | 2020-09-28 | 公開日 | 2021-06-02 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.66 Å) | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. Embo J., 40, 2021
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7AIP
| Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Reference Map) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Liko, I, Tehan, B.G, Almeida, F.G, Elkins, J, Singh, N.K, Abrusci, P, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC) | 登録日 | 2020-09-28 | 公開日 | 2021-06-02 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. Embo J., 40, 2021
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7AIQ
| Structure of Human Potassium Chloride Transporter KCC1 in NaCl (Subclass 1) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Solute carrier family 12 member 4, ... | 著者 | Ebenhoch, R, Chi, G, Man, H, Wang, D, McKinley, G, Mukhopadhyay, S.M.M, MacLean, E.M, Chalk, R, Moreau, C, Snee, M, Bohstedt, T, Singh, N.K, Abrusci, P, Liko, I, Tehan, B.G, Almeida, F.G, Arrowsmith, C.H, Tang, H, Robinson, C.V, Bountra, C, Edwards, A.M, Marsden, B.D, Burgess-Brown, N.A, Duerr, K.L, Structural Genomics Consortium (SGC) | 登録日 | 2020-09-28 | 公開日 | 2021-06-02 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.72 Å) | 主引用文献 | Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. Embo J., 40, 2021
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1IZC
| Crystal Structure Analysis of Macrophomate synthase | 分子名称: | MAGNESIUM ION, PYRUVIC ACID, macrophomate synthase intermolecular Diels-Alderase | 著者 | Ose, T, Watanabe, K, Mie, T, Honma, M, Watanabe, H, Yao, M, Oikawa, H, Tanaka, I. | 登録日 | 2002-10-01 | 公開日 | 2003-04-01 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase. Nature, 422, 2003
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1IPG
| SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P | 分子名称: | BEM1 PROTEIN | 著者 | Terasawa, H, Noda, Y, Ito, T, Hatanaka, H, Ichikawa, S, Ogura, K, Sumimoto, H, Inagaki, F. | 登録日 | 2001-05-14 | 公開日 | 2001-08-15 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif. EMBO J., 20, 2001
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1IP9
| SOLUTION STRUCTURE OF THE PB1 DOMAIN OF BEM1P | 分子名称: | BEM1 PROTEIN | 著者 | Terasawa, H, Noda, Y, Ito, T, Hatanaka, H, Ichikawa, S, Ogura, K, Sumimoto, H, Inagaki, F. | 登録日 | 2001-04-26 | 公開日 | 2001-08-15 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and ligand recognition of the PB1 domain: a novel protein module binding to the PC motif. EMBO J., 20, 2001
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1J1H
| Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus | 分子名称: | Small Protein B | 著者 | Someya, T, Nameki, N, Hosoi, H, Suzuki, S, Hatanaka, H, Fujii, M, Terada, T, Shirouzu, M, Inoue, Y, Shibata, T, Kuramitsu, S, Yokoyama, S, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-12-04 | 公開日 | 2003-02-11 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of a tmRNA-binding protein, SmpB, from Thermus thermophilus FEBS Lett., 535, 2003
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1J4J
| Crystal Structure of Tabtoxin Resistance Protein (form II) complexed with an Acyl Coenzyme A | 分子名称: | ACETYL COENZYME *A, TABTOXIN RESISTANCE PROTEIN | 著者 | He, H, Ding, Y, Bartlam, M, Zhang, R, Duke, N, Joachimiak, A, Shao, Y, Cao, Z, Tang, H, Liu, Y, Jiang, F, Liu, J, Zhao, N, Rao, Z. | 登録日 | 2001-10-02 | 公開日 | 2003-06-03 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation. J.Mol.Biol., 325, 2003
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8FTL
| Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1 | 分子名称: | 3C-like proteinase nsp5, N-([1,1'-biphenyl]-4-yl)-2-chloro-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]acetamide | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2023-01-12 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Crystal structure of the SARS-CoV-2 (COVID-19) main protease (Mpro) in complex with inhibitor Jun89-3-C1 To Be Published
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8DGB
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) Q192T Mutant in Complex with Inhibitor GC376 | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-23 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DCZ
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) M165Y Mutant in Complex with Nirmatrelvir | 分子名称: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DD1
| SARS-CoV-2 Main Protease (Mpro) H164N Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DFN
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H164N Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Butler, S.G, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-22 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DFE
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-22 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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8DD9
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144L Mutant in Complex with Inhibitor GC376 | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Jacobs, L.M.C, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-17 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Naturally Occurring Mutations of SARS-CoV-2 Main Protease Confer Drug Resistance to Nirmatrelvir. Acs Cent.Sci., 9, 2023
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5ZZ8
| Structure of the Herpes simplex virus type 2 C-capsid with capsid-vertex-specific component | 分子名称: | Major capsid protein, UL17, UL25, ... | 著者 | Wang, J.L, Yuan, S, Zhu, D.J, Tang, H, Wang, N, Chen, W.Y, Gao, Q, Li, Y.H, Wang, J.Z, Liu, H.R, Zhang, X.Z, Rao, Z.H, Wang, X.X. | 登録日 | 2018-05-31 | 公開日 | 2018-10-10 | 最終更新日 | 2019-11-06 | 実験手法 | ELECTRON MICROSCOPY (3.75 Å) | 主引用文献 | Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component. Nat Commun, 9, 2018
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1J70
| CRYSTAL STRUCTURE OF YEAST ATP SULFURYLASE | 分子名称: | ATP SULPHURYLASE, PHOSPHATE ION, SODIUM ION | 著者 | Lalor, D.J, Schnyder, T, Saridakis, V, Pilloff, D.E, Dong, A, Tang, H, Leyh, T.S, Pai, E.F. | 登録日 | 2001-05-15 | 公開日 | 2003-06-17 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity. Protein Eng., 16, 2003
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1J03
| Solution structure of a putative steroid-binding protein from Arabidopsis | 分子名称: | putative steroid binding protein | 著者 | Suzuki, S, Hatanaka, H, Kigawa, T, Terada, T, Shirouzu, M, Seki, M, Shinozaki, K, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | 登録日 | 2002-10-29 | 公開日 | 2003-12-16 | 最終更新日 | 2023-12-27 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of an Arabidopsis homologue of the mammalian membrane-associated progesterone receptor To be Published
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8D4L
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144A Mutant | 分子名称: | 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4K
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) H172Y Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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8D4M
| Crystal Structure of SARS-CoV-2 Main Protease (Mpro) S144A Mutant in Complex with Inhibitor GC376 | 分子名称: | (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase nsp5 | 著者 | Lewandowski, E.M, Hu, Y, Tan, H, Wang, J, Chen, Y. | 登録日 | 2022-06-02 | 公開日 | 2022-07-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | 主引用文献 | Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir. Biorxiv, 2022
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