8HC9
 
 | | SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 3 YB13-292 Fabs (3 RBD down) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of YB13-292 Fab, ... | | 著者 | Liu, B, Gao, X, Chen, Q, Li, Z, Su, M, He, J, Xiong, X. | | 登録日 | 2022-11-01 | | 公開日 | 2023-01-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (6.03 Å) | | 主引用文献 | Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants.
Nat Commun, 14, 2023
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8HC2
 | | SARS-CoV-2 Omicron BA.1 spike trimer (6P) in complex with 1 YB9-258 Fab (1 RBD up) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of YB9-258 Fab, ... | | 著者 | Liu, B, Gao, X, Chen, Q, Li, Z, Su, M, He, J, Xiong, X. | | 登録日 | 2022-11-01 | | 公開日 | 2023-01-25 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (6.21 Å) | | 主引用文献 | Somatically hypermutated antibodies isolated from SARS-CoV-2 Delta infected patients cross-neutralize heterologous variants.
Nat Commun, 14, 2023
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8E8I
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8EC5
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7Y99
 | | Crystal Structure Analysis of cp2 bound BCLxl | | 分子名称: | Bcl-2-like protein 1, CP2 peptide, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide | | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | | 登録日 | 2022-06-24 | | 公開日 | 2023-09-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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7YAA
 | | Crystal structure analysis of cp3 bound BCLxl | | 分子名称: | Bcl-2-like protein 1, GLYCEROL, N-(2-acetamidoethyl)-4-(4-methanoyl-1,3-thiazol-2-yl)benzamide, ... | | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | | 登録日 | 2022-06-27 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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7Y90
 | | Crystal Structure Analysis of cp1 bound BCL2 | | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide | | 著者 | Li, F.W. | | 登録日 | 2022-06-24 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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7YA5
 | | Crystal structure analysis of cp1 bound BCL2/G101V | | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Apoptosis regulator Bcl-2, cp1 peptide | | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | | 登録日 | 2022-06-27 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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7YB7
 | | anti-apoptotic protein BCL-2-M12 | | 分子名称: | Apoptosis regulator Bcl-2,Bcl-2-like protein 1, N-(2-acetamidoethyl)-4-(4,5-dihydro-1,3-thiazol-2-yl)benzamide, cp2 peptide | | 著者 | Li, F.W, Liu, C, Wu, D.L. | | 登録日 | 2022-06-29 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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7Y8D
 | | Crystal structure of cp1 bound BCLxl | | 分子名称: | (2R)-3-[2-(aminomethyl)-3-azanyl-1-[4-[2-(2-chloranylethanoylamino)ethylcarbamoyl]phenyl]prop-1-enyl]sulfanyl-2-(carboxyamino)propanoic acid, Bcl-2-like protein 1, cp1 peptide | | 著者 | Li, F.W, Liu, C, Wu, C.L, Wu, D.L. | | 登録日 | 2022-06-23 | | 公開日 | 2023-11-15 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-X L by engaging a single-residue discrepancy.
Nat Commun, 15, 2024
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5W2E
 | | HCV NS5B RNA-dependent RNA polymerase in complex with non-nucleoside inhibitor MK-8876 | | 分子名称: | 2-(4-fluorophenyl)-5-(11-fluoro-6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)-N-methyl-6-[methyl(methylsulfonyl)amino]-1-benzofuran-3-carboxamide, Genome polyprotein | | 著者 | Lesburg, C.A, Ummat, A. | | 登録日 | 2017-06-06 | | 公開日 | 2017-08-16 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Development of a New Structural Class of Broadly Acting HCV Non-Nucleoside Inhibitors Leading to the Discovery of MK-8876.
ChemMedChem, 12, 2017
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8KEB
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6AH3
 | | Cryo-EM structure of yeast Ribonuclease P with pre-tRNA substrate | | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, ... | | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | | 登録日 | 2018-08-16 | | 公開日 | 2018-10-17 | | 最終更新日 | 2025-04-09 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
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6N6O
 | | Crystal structure of the human TTK in complex with an inhibitor | | 分子名称: | 1,2-ETHANEDIOL, 4-({5-chloro-4-[(cis-4-hydroxy-4-methylcyclohexyl)oxy]-7H-pyrrolo[2,3-d]pyrimidin-2-yl}amino)-N,N-dimethyl-3-{[(2R)-1,1,1-trifluoropropan-2-yl]oxy}benzamide, Dual specificity protein kinase TTK, ... | | 著者 | Fenalti, G. | | 登録日 | 2018-11-26 | | 公開日 | 2019-05-15 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Design and Optimization Leading to an Orally Active TTK Protein Kinase Inhibitor with Robust Single Agent Efficacy.
J.Med.Chem., 62, 2019
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8ZHQ
 | | SFTSV Gn in complex with JK-8/12 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelopment polyprotein, ... | | 著者 | Shang, H, Guo, Y, Zhang, N, Liu, W, Li, H. | | 登録日 | 2024-05-11 | | 公開日 | 2025-01-08 | | 実験手法 | ELECTRON MICROSCOPY (2.37 Å) | | 主引用文献 | Discovery and characterization of potent broadly neutralizing antibodies from human survivors of severe fever with thrombocytopenia syndrome.
Ebiomedicine, 111, 2024
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6AGB
 | | Cryo-EM structure of yeast Ribonuclease P | | 分子名称: | RNases MRP/P 32.9 kDa subunit, Ribonuclease P RNA, Ribonuclease P protein subunit RPR2, ... | | 著者 | Lan, P, Tan, M, Wu, J, Lei, M. | | 登録日 | 2018-08-10 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
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8TWX
 | | Synthesis and Evaluation of Diaryl Ether Modulators of the Leukotriene A4 Hydrolase Aminopeptidase Activity | | 分子名称: | 5-[4-(4-chlorophenoxy)phenyl]-1H-pyrazol-3-amine, Leukotriene A-4 hydrolase, ZINC ION | | 著者 | Lee, K.H, Lee, S.H, Paige, M, Noble, S.M. | | 登録日 | 2023-08-21 | | 公開日 | 2024-08-28 | | 最終更新日 | 2025-03-05 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Synthesis and Evaluation of diaryl ether modulators of the leukotriene A 4 hydrolase aminopeptidase activity.
Eur.J.Med.Chem., 272, 2024
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8Z9K
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8Z8U
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8Z8Q
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8ZA0
 | | Crystal structure of OR4K15 ribozyme | | 分子名称: | MAGNESIUM ION, RNA (5'-R(*UP*CP*UP*GP*GP*GP*CP*CP*AP*GP*GP*CP*AP*GP*G)-3') | | 著者 | Ren, Y, Huang, L. | | 登録日 | 2024-04-24 | | 公開日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | | 主引用文献 | A general strategy for engineering GU base pairs to facilitate RNA crystallization.
Nucleic Acids Res., 53, 2025
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8ZAU
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8ZA4
 | | Crystal structure of OR4K15 ribozyme mutant - chainBDF C2U | | 分子名称: | RNA (5'-R(*CP*UP*UP*GP*CP*GP*CP*UP*CP*AP*AP*CP*CP*AP*GP*A)-3'), RNA (5'-R(*UP*CP*UP*GP*GP*GP*CP*CP*AP*GP*GP*CP*AP*GP*G)-3') | | 著者 | Ren, Y, Huang, L. | | 登録日 | 2024-04-24 | | 公開日 | 2025-03-19 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | A general strategy for engineering GU base pairs to facilitate RNA crystallization.
Nucleic Acids Res., 53, 2025
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8XJV
 | | Structural basis for the linker histone H5-nucleosome binding and chromatin compaction | | 分子名称: | DNA, Histone H2A, Histone H2B 1.1, ... | | 著者 | Li, W.Y, Song, F, Zhu, P. | | 登録日 | 2023-12-22 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structural basis for linker histone H5-nucleosome binding and chromatin fiber compaction.
Cell Res., 34, 2024
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9KPH
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