7Z6S
 
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3FKU
 | | Crystal structure of influenza hemagglutinin (H5) in complex with a broadly neutralizing antibody F10 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, Neutralizing antibody F10, ... | | 著者 | Hwang, W.C, Santelli, E, Stec, B, Wei, G, Cadwell, G, Bankston, L.A, Sui, J, Perez, S, Aird, D, Chen, L.M, Ali, M, Murakami, A, Yammanuru, A, Han, T, Cox, N, Donis, R.O, Liddington, R.C, Marasco, W.A. | | 登録日 | 2008-12-17 | | 公開日 | 2009-02-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses.
Nat.Struct.Mol.Biol., 16, 2009
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1DWK
 | | STRUCTURE OF CYANASE WITH THE DI-ANION OXALATE BOUND AT THE ENZYME ACTIVE SITE | | 分子名称: | CYANATE HYDRATASE, OXALATE ION, SULFATE ION | | 著者 | Walsh, M.A, Otwinowski, Z, Perrakis, A, Anderson, P.M, Joachimiak, A. | | 登録日 | 1999-12-07 | | 公開日 | 2000-05-16 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site.
Structure, 8, 2000
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1DW9
 | | Structure of cyanase reveals that a novel dimeric and decameric arrangement of subunits is required for formation of the enzyme active site | | 分子名称: | CHLORIDE ION, CYANATE LYASE, SULFATE ION | | 著者 | Walsh, M.A, Otwinowski, Z, Perrakis, A, Anderson, P.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 1999-12-03 | | 公開日 | 2000-05-16 | | 最終更新日 | 2019-08-21 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structure of Cyanase Reveals that a Novel Dimeric and Decameric Arrangement of Subunits is Required for Formation of the Enzyme Active Site
Structure, 8, 2000
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7ZOT
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3RMP
 | | Structural basis for the recognition of attP substrates by P4-like integrases | | 分子名称: | 5'-D(*TP*AP*AP*TP*GP*AP*CP*CP*AP*CP*CP*AP*AP*TP*A)-3', 5'-D(*TP*AP*TP*TP*GP*GP*TP*GP*GP*TP*CP*AP*TP*TP*A)-3', CP4-like integrase | | 著者 | Szwagierczak, A, Popowicz, G.M, Holak, T.A, Rakin, A, Antonenka, U. | | 登録日 | 2011-04-21 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | Structural basis for the recognition of attP substrates by P4-like integrases
To be Published
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7RCB
 | | Crystal Structure of a PMS2 VUS | | 分子名称: | Mismatch repair endonuclease PMS2 | | 著者 | D'Arcy, B.M, Prakash, A. | | 登録日 | 2021-07-07 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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7RCI
 | | Crystal Structure of a PMS2 VUS with Substrate | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 | | 著者 | D'Arcy, B.M, Prakash, A. | | 登録日 | 2021-07-07 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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7RCK
 | | Crystal Structure of PMS2 with Substrate | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mismatch repair endonuclease PMS2 | | 著者 | D'Arcy, B.M, Prakash, A. | | 登録日 | 2021-07-07 | | 公開日 | 2022-03-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | PMS2 variant results in loss of ATPase activity without compromising mismatch repair.
Mol Genet Genomic Med, 10, 2022
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2KLT
 | | Second Ca2+ binding domain of NCX1.3 | | 分子名称: | Sodium/calcium exchanger 1 | | 著者 | Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. | | 登録日 | 2009-07-08 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
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2KLS
 | | Apo-form of the second Ca2+ binding domain of NCX1.4 | | 分子名称: | Sodium/calcium exchanger 1 | | 著者 | Hilge, M, Aelen, J, Foarce, A, Perrakis, A, Vuister, G.W. | | 登録日 | 2009-07-08 | | 公開日 | 2009-08-18 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ca2+ regulation in the Na+/Ca2+ exchanger features a dual electrostatic switch mechanism.
Proc.Natl.Acad.Sci.USA, 106, 2009
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1V6J
 | | peanut lectin-lactose complex crystallized in orthorhombic form at acidic pH | | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure.
Acta Crystallogr.,Sect.D, 60, 2004
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1V6L
 | | Peanut lectin-lactose complex in the presence of 9mer peptide (PVIWSSATG) | | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure.
Acta Crystallogr.,Sect.D, 60, 2004
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1V6K
 | | Peanut lectin-lactose complex in the presence of peptide(IWSSAGNVA) | | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure.
Acta Crystallogr.,Sect.D, 60, 2004
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1V6I
 | | Peanut lectin-lactose complex in acidic pH | | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ... | | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2003-12-01 | | 公開日 | 2004-02-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure.
Acta Crystallogr.,Sect.D, 60, 2004
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3WSO
 | | Crystal structure of the Skp1-FBG3 complex | | 分子名称: | F-box only protein 44, S-phase kinase-associated protein 1 | | 著者 | Kumanomidou, T, Nishio, K, Takagi, K, Nakagawa, T, Suzuki, A, Yamane, T, Tokunaga, F, Iwai, K, Murakami, A, Yoshida, Y, Tanaka, K, Mizushima, T. | | 登録日 | 2014-03-18 | | 公開日 | 2015-03-25 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Structural Differences between a Glycoprotein Specific F-Box Protein Fbs1 and Its Homologous Protein FBG3
Plos One, 10, 2015
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3TW2
 | | High resolution structure of human histidine triad nucleotide-binding protein 1 (hHINT1)/AMP complex in a monoclinic space group | | 分子名称: | ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1 | | 著者 | Dolot, R.M, Wlodarczyk, A, Ozga, M, Krakowiak, A, Nawrot, B. | | 登録日 | 2011-09-21 | | 公開日 | 2011-11-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | A new crystal form of human histidine triad nucleotide-binding protein 1 (hHINT1) in complex with adenosine 5'-monophosphate at 1.38 A resolution.
Acta Crystallogr.,Sect.F, 68, 2012
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7Z0N
 | | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators | | 分子名称: | CALCIUM ION, GLYCEROL, IODIDE ION, ... | | 著者 | Salgado-Polo, F, Clark, J.M, Macdonald, S.J.F, Barrett, T.N, Perrakis, A, Jamieson, A. | | 登録日 | 2022-02-23 | | 公開日 | 2022-05-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-Based Design of a Novel Class of Autotaxin Inhibitors Based on Endogenous Allosteric Modulators.
J.Med.Chem., 65, 2022
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5HJ0
 | | Crystal Structure of Mis18 'Yippee-like' Domain | | 分子名称: | Kinetochore protein mis18, ZINC ION | | 著者 | Medina-Pritchard, B, Subramanian, L, Allshire, R, Arockia Jeyaprakash, A. | | 登録日 | 2016-01-12 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | | 主引用文献 | Centromere localization and function of Mis18 requires Yippee-like domain-mediated oligomerization.
Embo Rep., 17, 2016
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5IJQ
 | | Crystal structure of autotaxin (ENPP2) re-refined | | 分子名称: | 7alpha-hydroxycholesterol, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | 著者 | Hausmann, J, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-03-02 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
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5IJS
 | | Crystal structure of autotaxin with orthovanadate bound as a trigonal bipyramidal intermediate analog | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7alpha-hydroxycholesterol, CALCIUM ION, ... | | 著者 | Hausmann, J, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-03-02 | | 公開日 | 2016-06-15 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural snapshots of the catalytic cycle of the phosphodiesterase Autotaxin.
J.Struct.Biol., 195, 2016
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5LQQ
 | | Structure of Autotaxin (ENPP2) with LM350 | | 分子名称: | 3-(6-chloranyl-2-methyl-1-phenyl-indol-3-yl)sulfanylbenzoic acid, CALCIUM ION, Ectonucleotide pyrophosphatase/phosphodiesterase family member 2, ... | | 著者 | Keune, W.J, Heidebrecht, T, Castelmur, E, Joosten, R.P, Perrakis, A. | | 登録日 | 2016-08-17 | | 公開日 | 2016-12-28 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.
J. Med. Chem., 60, 2017
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3KJY
 | | Crystal structure of reduced HOMO SAPIENS CLIC3 | | 分子名称: | Chloride intracellular channel protein 3, SULFATE ION | | 著者 | Littler, D.R, Curmi, P.M.G, Breit, S.N, Perrakis, A. | | 登録日 | 2009-11-04 | | 公開日 | 2009-11-17 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of human CLIC3 at 2 A resolution
Proteins, 78, 2010
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1V6O
 | | Peanut lectin complexed with 10mer peptide (PVRIWSSATG) | | 分子名称: | CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION | | 著者 | Kundhavai Natchiar, S, Arockia Jeyaprakash, A, Ramya, T.N.C, Thomas, C.J, Suguna, K, Surolia, A, Vijayan, M. | | 登録日 | 2003-12-02 | | 公開日 | 2004-02-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural plasticity of peanut lectin: an X-ray analysis involving variation in pH, ligand binding and crystal structure.
Acta Crystallogr.,Sect.D, 60, 2004
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5WG8
 | | Structure of PP5C with LB-100; 7-oxabicyclo[2.2.1]heptane-2,3-dicarbonyl moiety modeled in the density | | 分子名称: | (1S,2R,3S,4R)-3-(4-methylpiperazine-1-carbonyl)-7-oxabicyclo[2.2.1]heptane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ... | | 著者 | D'Arcy, B.M, Swingle, M.R, Honkanen, R.E, Prakash, A. | | 登録日 | 2017-07-13 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | The Antitumor Drug LB-100 Is a Catalytic Inhibitor of Protein Phosphatase 2A (PPP2CA) and 5 (PPP5C) Coordinating with the Active-Site Catalytic Metals in PPP5C.
Mol. Cancer Ther., 18, 2019
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