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1ZGK
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BU of 1zgk by Molmil
1.35 angstrom structure of the Kelch domain of Keap1
分子名称: Kelch-like ECH-associated protein 1
著者Li, X, Bottoms, C.A, Hannink, M, Beamer, L.J.
登録日2005-04-21
公開日2005-10-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Conserved solvent and side-chain interactions in the 1.35 Angstrom structure of the Kelch domain of Keap1.
Acta Crystallogr.,Sect.D, 61, 2005
6VUM
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BU of 6vum by Molmil
Structure of nevanimibe-bound human tetrameric ACAT1
分子名称: CHOLESTEROL, COENZYME A, OLEIC ACID, ...
著者Li, X, Long, T.
登録日2020-02-16
公開日2020-05-13
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.67 Å)
主引用文献Structure of nevanimibe-bound tetrameric human ACAT1.
Nature, 581, 2020
3NDM
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BU of 3ndm by Molmil
Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
分子名称: (3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide, Rho-Associated Protein Kinase (ROCK1)
著者Li, X.
登録日2010-06-07
公開日2010-12-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines.
Bioorg.Med.Chem.Lett., 20, 2010
2M9H
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BU of 2m9h by Molmil
DNA-binding domain of T. brucei telomeric protein tbTRF
分子名称: TTAGGG binding factor
著者Li, X, Ye, F, Zhang, M, Zhao, Y.
登録日2013-06-09
公開日2014-07-16
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Suppression of subtelomeric VSG switching by Trypanosoma brucei TRF requires its TTAGGG repeat-binding activity.
Nucleic Acids Res., 42, 2014
5YGI
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BU of 5ygi by Molmil
Crystal structure of human FPPS in complex with an inhibitor THZ93
分子名称: Farnesyl pyrophosphate synthase, MAGNESIUM ION, PHOSPHATE ION, ...
著者Li, X.
登録日2017-09-23
公開日2018-09-26
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery.
Cell, 175, 2018
5EE0
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BU of 5ee0 by Molmil
Crystal structure of OsYchF1 at pH 6.5
分子名称: Obg-like ATPase 1
著者Li, X, Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE9
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BU of 5ee9 by Molmil
Complex structure of OSYCHF1 with GMP-PNP
分子名称: GLYCEROL, MAGNESIUM ION, Obg-like ATPase 1, ...
著者Li, X, Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE1
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BU of 5ee1 by Molmil
Crystal structure of OsYchF1 at pH 7.85
分子名称: Obg-like ATPase 1
著者Li, X, Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
5EE3
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BU of 5ee3 by Molmil
COMPLEX STRUCTURE OF OSYCHF1 WITH AMP-PNP
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ...
著者Li, X, Chen, Z.
登録日2015-10-22
公開日2016-02-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献ATP binding by the P-loop NTPase OsYchF1 (an unconventional G protein) contributes to biotic but not abiotic stress responses
Proc.Natl.Acad.Sci.USA, 113, 2016
4YMQ
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BU of 4ymq by Molmil
X-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist
分子名称: 4-{3-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl]-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl}-N-[(2R)-4-hydroxybutan-2-yl]-N-methylbutanamide, GLYCEROL, Nuclear receptor ROR-gamma, ...
著者li, X.
登録日2015-03-07
公開日2015-04-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators.
Bioorg.Med.Chem.Lett., 25, 2015
4RED
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BU of 4red by Molmil
Crystal structure of human AMPK alpha1 KD-AID with K43A mutation
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1
著者Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K.
登録日2014-09-22
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
2FLU
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BU of 2flu by Molmil
Crystal Structure of the Kelch-Neh2 Complex
分子名称: Kelch-like ECH-associated protein 1, Nrf2
著者Li, X, Lo, J, Beamer, L, Hannink, M.
登録日2006-01-06
公開日2006-08-15
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.
Embo J., 25, 2006
4RER
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BU of 4rer by Molmil
Crystal structure of the phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex bound to AMP and cyclodextrin
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, ...
著者Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K.
登録日2014-09-23
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4.047 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
4REW
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BU of 4rew by Molmil
Crystal structure of the non-phosphorylated human alpha1 beta2 gamma1 holo-AMPK complex
分子名称: 5'-AMP-activated protein kinase catalytic subunit alpha-1, 5'-AMP-activated protein kinase subunit beta-2, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者Zhou, X.E, Ke, J, Li, X, Wang, L, Gu, X, de Waal, P.W, Tan, M.H.E, Wang, D, Wu, D, Xu, H.E, Melcher, K.
登録日2014-09-24
公開日2014-12-10
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (4.58 Å)
主引用文献Structural basis of AMPK regulation by adenine nucleotides and glycogen.
Cell Res., 25, 2015
7T6B
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BU of 7t6b by Molmil
Structure of S1PR2-heterotrimeric G13 signaling complex
分子名称: (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, X, Chen, H.
登録日2021-12-13
公開日2022-04-06
最終更新日2022-06-29
実験手法ELECTRON MICROSCOPY (3.19 Å)
主引用文献Structure of S1PR2-heterotrimeric G 13 signaling complex.
Sci Adv, 8, 2022
7XMX
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BU of 7xmx by Molmil
Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three F61 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, F61 heavy chain, F61 light chain, ...
著者Wang, X, Li, X.
登録日2022-04-27
公開日2022-11-23
実験手法ELECTRON MICROSCOPY (3.62 Å)
主引用文献Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages.
Cell Discov, 8, 2022
7XMZ
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BU of 7xmz by Molmil
Cryo-EM structure of SARS-CoV-2 spike glycoprotein in complex with three D2 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D2 heavy chain, D2 light chain, ...
著者Wang, X, Li, X.
登録日2022-04-27
公開日2022-11-23
実験手法ELECTRON MICROSCOPY (3.25 Å)
主引用文献Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages.
Cell Discov, 8, 2022
3NCZ
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BU of 3ncz by Molmil
X-Ray Co-structure of Rho-Associated Protein Kinase (ROCK1) with a potent 2H-isoquinolin-1-one inhibitor
分子名称: Rho-associated protein kinase 1, cis-4-amino-N-(7-chloro-1-oxo-1,2-dihydroisoquinolin-6-yl)cyclohexanecarboxamide
著者Li, X.
登録日2010-06-06
公開日2010-12-08
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: Part 2, optimization for blood pressure reduction in spontaneously hypertensive rats.
Bioorg.Med.Chem.Lett., 20, 2010
7XST
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BU of 7xst by Molmil
Cryo-EM structure of SARS-CoV-2 Omicron spike glycoprotein in complex with three F61 Fab and three D2 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D2 heavy chain, D2 light chain, ...
著者Wang, X, Li, X.
登録日2022-05-15
公開日2022-11-23
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Structural basis of a two-antibody cocktail exhibiting highly potent and broadly neutralizing activities against SARS-CoV-2 variants including diverse Omicron sublineages.
Cell Discov, 8, 2022
5T17
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BU of 5t17 by Molmil
NMR structure of the E. coli protein NPr, residues 1-85
分子名称: Phosphocarrier protein NPr
著者Wang, G, Li, X, Peterkofsky, A.
登録日2016-08-18
公開日2016-09-28
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of NPr, a bacterial signal-transducing protein that controls the phosphorylation state of the potassium transporter-regulating protein IIA Ntr.
Amino Acids, 35, 2008
2LEF
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BU of 2lef by Molmil
LEF1 HMG DOMAIN (FROM MOUSE), COMPLEXED WITH DNA (15BP), NMR, 12 STRUCTURES
分子名称: DNA (5'-D(*CP*AP*CP*CP*CP*TP*TP*TP*GP*AP*AP*GP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*CP*TP*TP*CP*AP*AP*AP*GP*GP*GP*TP*G)-3'), PROTEIN (LYMPHOID ENHANCER-BINDING FACTOR)
著者Li, X, Love, J.J, Case, D.A, Wright, P.E.
登録日1998-10-13
公開日1998-10-21
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献Structural basis for DNA bending by the architectural transcription factor LEF-1.
Nature, 376, 1995
7WJQ
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BU of 7wjq by Molmil
Crystal structure of GSDMB in complex with Ipah7.8
分子名称: Isoform 2 of Gasdermin-B, Probable E3 ubiquitin-protein ligase ipaH7.8
著者Li, X, Zhang, H, Yin, H.
登録日2022-01-07
公開日2023-01-11
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8
Nat Commun, 14, 2023
7LIB
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BU of 7lib by Molmil
X-ray crystal structure of a cyclic peptide containing beta-2-microglobulin (63-69) and a gamma-methylornithine turn unit
分子名称: Cyclic peptide ORD-TYR-LEU-LEU-PHI-TYR-THR-GLU-GMO-LYS-VAL-THR-MVA-THR-VAL-LYS
著者Wierzbicki, M, Nowick, J.S, Li, X.
登録日2021-01-26
公開日2021-08-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献An Improved Turn Structure for Inducing beta-Hairpin Formation in Peptides.
Angew.Chem.Int.Ed.Engl., 60, 2021
7N4X
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BU of 7n4x by Molmil
Structure of human NPC1L1 mutant-W347R
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
著者Li, X, Long, T.
登録日2021-06-04
公開日2021-09-01
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.33 Å)
主引用文献Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
7N4U
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BU of 7n4u by Molmil
Structure of human NPC1L1
分子名称: (2R)-2,5,7,8-TETRAMETHYL-2-[(4R,8R)-4,8,12-TRIMETHYLTRIDECYL]CHROMAN-6-OL, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, X, Long, T.
登録日2021-06-04
公開日2021-09-01
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.34 Å)
主引用文献Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021

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