9FL0
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9FKY
| Discovery of a Series of Covalent, Cell Active Bfl-1 Inhibitors | 分子名称: | Bcl-2-related protein A1, ~{N}-[4-[(1~{R},3~{R})-3-azanylcyclopentyl]oxyphenyl]-~{N}-[(1~{S})-1-[3-cyano-4-(trifluoromethyl)phenyl]ethyl]propanamide | 著者 | Hargreaves, D. | 登録日 | 2024-06-04 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.557 Å) | 主引用文献 | Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J.Med.Chem., 67, 2024
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9FKZ
| Discovery of a Series of Covalent, Cell Active Bfl-1 Inhibitors | 分子名称: | Bcl-2-related protein A1, ~{N}-[4-[(1~{R},3~{R})-3-azanylcyclopentyl]oxyphenyl]-~{N}-[(4-chlorophenyl)methyl]prop-2-enamide | 著者 | Hargreaves, D. | 登録日 | 2024-06-04 | 公開日 | 2024-10-02 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (1.684 Å) | 主引用文献 | Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J.Med.Chem., 67, 2024
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7XG7
| Crystal structure of PstS protein from cyanophage Syn19 | 分子名称: | GLYCEROL, PHOSPHATE ION, Phosphate transporter subunit | 著者 | Cai, K, Jiang, Y.L. | 登録日 | 2022-04-03 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol., 24, 2022
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7XG8
| Crystal structure of PstS protein from cyanophage P-SSM2 | 分子名称: | ABC transporter, substrate binding protein, phosphate, ... | 著者 | Cai, K, Jiang, Y.L. | 登録日 | 2022-04-03 | 公開日 | 2023-02-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Biochemical and structural characterization of the cyanophage-encoded phosphate-binding protein: implications for enhanced phosphate uptake of infected cyanobacteria Environ.Microbiol., 24, 2022
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2QIO
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3KRL
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8ZEM
| Crystal Structure of NLRP3 NACHT domain in complex with NP3-1 | 分子名称: | 1-[5-[2,3-bis(chloranyl)phenyl]-2,3-dihydro-1~{H}-inden-4-yl]-3-[4-(2-oxidanylpropan-2-yl)thiophen-2-yl]sulfonyl-urea, ADENOSINE-5'-DIPHOSPHATE, NACHT, ... | 著者 | Shi, C, Liu, Z.M. | 登録日 | 2024-05-06 | 公開日 | 2024-10-02 | 実験手法 | X-RAY DIFFRACTION (3.32 Å) | 主引用文献 | Deep-Learning-Driven Discovery of SN3-1, a Potent NLRP3 Inhibitor with Therapeutic Potential for Inflammatory Diseases. J.Med.Chem., 2024
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7X4X
| BTB domain of KEAP1 in complex with MEF | 分子名称: | 4-ethoxy-4-oxobutanoic acid, Kelch-like ECH-associated protein 1 | 著者 | Qu, L.Z. | 登録日 | 2022-03-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun., 605, 2022
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7X4W
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6UKM
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8D1Y
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5DZO
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8D24
| Crystal structure of Plasmodium falciparum GRP78-NBD in complex with VER155008 | 分子名称: | 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, Chaperone DnaK, SULFATE ION | 著者 | Mrozek, A, Park, H.W. | 登録日 | 2022-05-27 | 公開日 | 2023-05-31 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | A non-traditional crystal-based compound screening method targeting the ATP binding site of Plasmodium falciparum GRP78 for identification of novel nucleoside analogues. Front Mol Biosci, 9, 2022
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4W8F
| Crystal structure of the dynein motor domain in the AMPPNP-bound state | 分子名称: | Dynein heavy chain lysozyme chimera, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Cheng, H.-C, Bhabha, G, Zhang, N, Vale, R.D. | 登録日 | 2014-08-24 | 公開日 | 2014-11-12 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (3.541 Å) | 主引用文献 | Allosteric communication in the Dynein motor domain. Cell, 159, 2014
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8D20
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8D22
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6UKU
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 3 | 分子名称: | 4,4'-[propane-1,3-diylbis(6-methoxy-1-benzothiene-5,2-diyl)]bis(4-oxobutanoic acid), fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UL0
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 4 | 分子名称: | 4-{5-[(1Z)-3-{[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-5-yl]oxy}prop-1-en-1-yl]-6-methoxy-1-benzothiophen-2-yl}-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKV
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 9 | 分子名称: | 4-[6-(3-{[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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7XJR
| MLXase AlXyn26A | 分子名称: | AlXyn26A | 著者 | Zhang, Y.Z, Chen, X.L, Zhao, F, Yu, C.M. | 登録日 | 2022-04-18 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A novel class of xylanases specifically degrade marine red algal beta 1,3/1,4-mixed-linkage xylan. J.Biol.Chem., 299, 2023
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6UKX
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 11 | 分子名称: | 4,4'-{propane-1,3-diylbis[oxy(5-methoxy-1-benzothiene-6,2-diyl)]}bis(4-oxobutanoic acid), fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKZ
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 6 | 分子名称: | 4-[5-(2-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}ethoxy)-6-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKW
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 10 | 分子名称: | 4-[6-(3-{[2-(3-carboxypropanoyl)-4-fluoro-6-methoxy-1-benzothiophen-5-yl]oxy}propoxy)-5-methoxy-1-benzothiophen-2-yl]-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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6UKY
| STING C-terminal Domain Complexed with Non-cyclic Dinucleotide Compound 12 | 分子名称: | 4-(6-{3-[2-(3-carboxypropanoyl)-6-methoxy-1-benzothiophen-4-yl]propyl}-5-methoxy-1-benzothiophen-2-yl)-4-oxobutanoic acid, fusion protein of Ubiquitin-like protein SMT3 and Stimulator of interferon protein c-terminal domain | 著者 | Lesburg, C.A. | 登録日 | 2019-10-06 | 公開日 | 2020-08-19 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | An orally available non-nucleotide STING agonist with antitumor activity. Science, 369, 2020
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