6BLK
| |
6CYZ
| |
5X3V
| |
5ZVD
| |
5ZVG
| |
5ZVE
| |
8FLM
| Cryo-EM structure of STING oligomer bound to cGAMP, NVS-STG2 and C53 | 分子名称: | 1-[(2-chloro-6-fluorophenyl)methyl]-3,3-dimethyl-2-oxo-N-[(2,4,6-trifluorophenyl)methyl]-2,3-dihydro-1H-indole-6-carboxamide, 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, ... | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
|
|
8FLK
| Cryo-EM structure of STING oligomer bound to cGAMP and NVS-STG2 | 分子名称: | 4-({[4-(2-tert-butyl-5,5-dimethyl-1,3-dioxan-2-yl)phenyl]methyl}amino)-3-methoxybenzoic acid, Stimulator of interferon genes protein, cGAMP | 著者 | Li, J, Canham, S.M, Zhang, X, Bai, X, Feng, Y. | 登録日 | 2022-12-21 | 公開日 | 2023-11-01 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Activation of human STING by a molecular glue-like compound. Nat.Chem.Biol., 20, 2024
|
|
8HHE
| |
2JQW
| |
7VFP
| Cytochrome c-type biogenesis protein CcmABCD from E. coli in complex with heme and single ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Cytochrome c biogenesis ATP-binding export protein CcmA, Heme exporter protein B, ... | 著者 | Li, J, Zheng, W, Gu, M, Zhang, K, Zhu, J.P. | 登録日 | 2021-09-13 | 公開日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (4.03 Å) | 主引用文献 | Structures of the CcmABCD heme release complex at multiple states. Nat Commun, 13, 2022
|
|
3T2S
| HSP90 N-terminal domain bound to AGS | 分子名称: | Heat shock protein HSP 90-alpha, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | 著者 | Li, J. | 登録日 | 2011-07-23 | 公開日 | 2012-01-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | HSP90 N-terminal domain bound to AGS To be published
|
|
5F3X
| Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM | 分子名称: | Ankyrin repeat and SAM domain-containing protein 4B, CHLORIDE ION, Harmonin | 著者 | Li, J, He, Y, Lu, Q, Zhang, M. | 登録日 | 2015-12-03 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.649 Å) | 主引用文献 | Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell, 36, 2016
|
|
5F3Y
| Crystal Structure of Myo7b N-MyTH4-FERM-SH3 in complex with Anks4b CEN | 分子名称: | Ankyrin repeat and SAM domain-containing protein 4B, Unconventional myosin-VIIb | 著者 | Li, J, He, Y, Lu, Q, Zhang, M. | 登録日 | 2015-12-03 | 公開日 | 2016-03-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.409 Å) | 主引用文献 | Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell, 36, 2016
|
|
7C6P
| Bromodomain-containing 4 BD2 in complex with 3',4',7,8- Tetrahydroxyflavonoid | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4 | 著者 | Li, J, Yu, K, Luo, Y, Zheng, W, Liang, W, Zhu, J. | 登録日 | 2020-05-22 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
|
|
7C2Z
| Bromodomain-containing 4 BD1 in complex with 3',4',7,8-Tetrahydroxyflavone | 分子名称: | 2-[3,4-bis(oxidanyl)phenyl]-7,8-bis(oxidanyl)chromen-4-one, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Li, J, Zhu, J. | 登録日 | 2020-05-10 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Discovery of the natural product 3',4',7,8-tetrahydroxyflavone as a novel and potent selective BRD4 bromodomain 2 inhibitor. J Enzyme Inhib Med Chem, 36, 2021
|
|
7DVM
| |
1C8U
| |
7CUQ
| 2.55-Angstrom Cryo-EM structure of Cytochrome bo3 from Escherichia coli in Native Membrane | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | 著者 | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | 登録日 | 2020-08-24 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.64 Å) | 主引用文献 | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7CUW
| Ubiquinol Binding Site of Cytochrome bo3 from Escherichia coli | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | 著者 | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | 登録日 | 2020-08-25 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | 主引用文献 | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7CUB
| 2.55-Angstrom Cryo-EM structure of Cytochrome bo3 from Escherichia coli in Native Membrane | 分子名称: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, COPPER (II) ION, Cytochrome bo(3) ubiquinol oxidase subunit 1, ... | 著者 | Li, J, Han, L, Gennis, R.B, Zhu, J.P, Zhang, K. | 登録日 | 2020-08-22 | 公開日 | 2021-08-25 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.55 Å) | 主引用文献 | Cryo-EM structures of Escherichia coli cytochrome bo3 reveal bound phospholipids and ubiquinone-8 in a dynamic substrate binding site. Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
7W1Y
| Human MCM double hexamer bound to natural DNA duplex (polyAT/polyTA) | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, DNA (49-MER), ... | 著者 | Li, J, Dong, J, Dang, S, Zhai, Y. | 登録日 | 2021-11-21 | 公開日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | The human pre-replication complex is an open complex. Cell, 186, 2023
|
|
4M2S
| Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR | 分子名称: | (4R,11R,18R)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1A | 著者 | Li, J, Jaimes, K.F, Aller, S.G. | 登録日 | 2013-08-05 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | 主引用文献 | Refined structures of mouse P-glycoprotein. Protein Sci., 23, 2014
|
|
4M1M
| |
4M2T
| Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS | 分子名称: | (4S,11S,18S)-4,11,18-tri(propan-2-yl)-6,13,20-triselena-3,10,17,22,23,24-hexaazatetracyclo[17.2.1.1~5,8~.1~12,15~]tetracosa-1(21),5(24),7,12(23),14,19(22)-hexaene-2,9,16-trione, Multidrug resistance protein 1A | 著者 | Li, J, Jaimes, K.F, Aller, S.G. | 登録日 | 2013-08-05 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (4.35 Å) | 主引用文献 | Refined structures of mouse P-glycoprotein. Protein Sci., 23, 2014
|
|