5GGO
 
 | | Crystal structure of N-terminal domain of human protein O-mannose beta-1,2-N-acetylglucosaminyltransferase in complex with GalNac-beta1,3-GlcNAc-beta-pNP | | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-4-nitrophenyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1 | | 著者 | Kuwabara, N, Senda, T, Kato, R. | | 登録日 | 2016-06-16 | | 公開日 | 2016-08-10 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.502 Å) | | 主引用文献 | Carbohydrate-binding domain of the POMGnT1 stem region modulates O-mannosylation sites of alpha-dystroglycan
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
7CTQ
 | | Peptidyl tryptophan dihydroxylase QhpG essential for tryptophylquinone cofactor biogenesis | | 分子名称: | (2~{R},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-6-(cyclohexylmethoxy)-2-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol, FLAVIN-ADENINE DINUCLEOTIDE, HEXANE-1,6-DIOL, ... | | 著者 | Oozeki, T, Nakai, T, Okajima, T. | | 登録日 | 2020-08-20 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | | 主引用文献 | Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor.
Nat Commun, 12, 2021
|
|
3RP2
 | | THE STRUCTURE OF RAT MAST CELL PROTEASE II AT 1.9-ANGSTROMS RESOLUTION | | 分子名称: | RAT MAST CELL PROTEASE II | | 著者 | Reynolds, R, Remington, S, Weaver, L, Fischer, R, Anderson, W, Ammon, H, Matthews, B. | | 登録日 | 1984-09-10 | | 公開日 | 1984-10-29 | | 最終更新日 | 2017-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The structure of rat mast cell protease II at 1.9-A resolution.
Biochemistry, 27, 1988
|
|
7E18
 | | Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor YH-53 | | 分子名称: | 1,2-ETHANEDIOL, N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]-4-methoxy-1H-indole-2-carboxamide, Replicase polyprotein 1ab | | 著者 | Senda, M, Konno, S, Hayashi, Y, Senda, T. | | 登録日 | 2021-02-01 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.
J.Med.Chem., 65, 2022
|
|
7E19
 | | Crystal structure of SAR-CoV-2 3CL protease complex with inhibitor SH-5 | | 分子名称: | (phenylmethyl) N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-1-oxidanylidene-3-[(3S)-2-oxidanylidenepyrrolidin-3-yl]propan-2-yl]amino]-4-methyl-1-oxidanylidene-pentan-2-yl]amino]-3-methyl-1-oxidanylidene-butan-2-yl]carbamate, 3C-like proteinase | | 著者 | Senda, M, Konno, S, Hayashi, Y, Senda, T. | | 登録日 | 2021-02-01 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.
J.Med.Chem., 65, 2022
|
|
7VR7
 | | Inward-facing structure of human EAAT2 in the WAY213613-bound state | | 分子名称: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Kato, T, Kusakizako, T, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2021-10-22 | | 公開日 | 2022-08-10 | | 最終更新日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Nat Commun, 13, 2022
|
|
7VR8
 | | Inward-facing structure of human EAAT2 in the substrate-free state | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, ... | | 著者 | Kato, T, Kusakizako, T, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2021-10-22 | | 公開日 | 2022-08-10 | | 最終更新日 | 2022-09-28 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2.
Nat Commun, 13, 2022
|
|
7XJI
 | | Solabegron-activated dog beta3 adrenergic receptor | | 分子名称: | 3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid, Beta-3 adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | 著者 | Shihoya, W, Nureki, O. | | 登録日 | 2022-04-18 | | 公開日 | 2022-05-04 | | 最終更新日 | 2022-06-29 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of the beta 3 adrenergic receptor bound to solabegron and isoproterenol.
Biochem.Biophys.Res.Commun., 611, 2022
|
|
7E7Z
 | |
7E87
 | |
7E89
 | |
7E84
 | | CryoEM structure of human Kv4.2-KChIP1 complex | | 分子名称: | Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | | 著者 | Kise, Y, Nureki, O. | | 登録日 | 2021-02-28 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
|
|
7E8E
 | |
7E83
 | |
7E8G
 | |
7E8H
 | | CryoEM structure of human Kv4.2-DPP6S-KChIP1 complex | | 分子名称: | Dipeptidyl aminopeptidase-like protein 6, Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | | 著者 | Kise, Y, Nureki, O. | | 登録日 | 2021-03-01 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
|
|
7E8B
 | | CryoEM structure of human Kv4.2-DPP6S complex | | 分子名称: | Dipeptidyl aminopeptidase-like protein 6, Potassium voltage-gated channel subfamily D member 2 | | 著者 | Kise, Y, Nureki, O. | | 登録日 | 2021-03-01 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
|
|
7F3F
 | | CryoEM structure of human Kv4.2-KChIP1 complex | | 分子名称: | Isoform 2 of Kv channel-interacting protein 1, Potassium voltage-gated channel subfamily D member 2 | | 著者 | Kise, Y, Nureki, O. | | 登録日 | 2021-06-16 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
|
|
7F0J
 | | CryoEM structure of human Kv4.2 | | 分子名称: | Potassium voltage-gated channel subfamily D member 2, ZINC ION | | 著者 | Kise, Y, Nureki, O. | | 登録日 | 2021-06-04 | | 公開日 | 2021-10-13 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis of gating modulation of Kv4 channel complexes.
Nature, 599, 2021
|
|
5XX2
 | | A BPTI-[5,55] variant with C14GA38L mutations | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M. | | 登録日 | 2017-07-01 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5XX4
 | | A BPTI-[5,55] variant with C14GA38K mutations | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M. | | 登録日 | 2017-07-01 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5XX5
 | | A BPTI-[5,55] variant with C14GA38I mutations | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M. | | 登録日 | 2017-07-01 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
5XX3
 | | A BPTI-[5,55] variant with C14GA38G mutations | | 分子名称: | Pancreatic trypsin inhibitor, SULFATE ION | | 著者 | Islam, M.M. | | 登録日 | 2017-07-01 | | 公開日 | 2018-07-04 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | | 主引用文献 | Hydrophobic surface residues can stabilize a protein through improved water-protein interactions.
Febs J., 2019
|
|
6KAM
 | | Crystal structure of FKRP in complex with Ba ion, CDP-ribtol, and sugar acceptor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-alpha-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, BARIUM ION, ... | | 著者 | Kuwabara, N. | | 登録日 | 2019-06-23 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.
Nat Commun, 11, 2020
|
|
6KAK
 | | Crystal structure of FKRP in complex with Mg ion | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fukutin-related protein, MAGNESIUM ION, ... | | 著者 | Kuwabara, N. | | 登録日 | 2019-06-23 | | 公開日 | 2020-01-15 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.056 Å) | | 主引用文献 | Crystal structures of fukutin-related protein (FKRP), a ribitol-phosphate transferase related to muscular dystrophy.
Nat Commun, 11, 2020
|
|
