3HDN
 
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3HDM
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3II9
 | | Crystal structure of glutaryl-coa dehydrogenase from Burkholderia pseudomallei at 1.73 Angstrom | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Glutaryl-CoA dehydrogenase, ... | | 著者 | Ismagilov, R.F, Li, L, Du, W.B, Staker, B, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), Seattle Structural Genomics Center for Infectious Disease (SSGCID) | | 登録日 | 2009-07-31 | | 公開日 | 2009-12-15 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | User-loaded SlipChip for equipment-free multiplexed nanoliter-scale experiments.
J.Am.Chem.Soc., 132, 2010
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6OCQ
 | | Crystal structure of RIP1 kinase in complex with a pyrrolidine | | 分子名称: | 1-[(2S)-2-(3-fluorophenyl)pyrrolidin-1-yl]-2,2-dimethylpropan-1-one, Receptor-interacting serine/threonine-protein kinase 1, SULFATE ION | | 著者 | Thorpe, J.H, Harris, P.A. | | 登録日 | 2019-03-25 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.793 Å) | | 主引用文献 | Discovery and Lead-Optimization of 4,5-Dihydropyrazoles as Mono-Kinase Selective, Orally Bioavailable and Efficacious Inhibitors of Receptor Interacting Protein 1 (RIP1) Kinase.
J.Med.Chem., 62, 2019
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6OYW
 | | ASK1 kinase domain in complex with Compound 11 | | 分子名称: | (19S)-19-methyl-16,17,18,19-tetrahydro-8,4-(azeno)[1,2,4]triazolo[4,3-f][1,6,13]benzoxadiazacyclohexadecin-10(9H)-one, MAGNESIUM ION, Mitogen-activated protein kinase kinase kinase 5 | | 著者 | Marcotte, D.J. | | 登録日 | 2019-05-15 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.603 Å) | | 主引用文献 | Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
J.Med.Chem., 62, 2019
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6P5C
 | | Bacillus Fragment DNA polymerase mutant I716M | | 分子名称: | DNA (5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*C)-3'), DNA (5'-D(P*GP*CP*GP*TP*GP*AP*TP*CP*G)-3'), DNA polymerase I, ... | | 著者 | Wu, E.Y. | | 登録日 | 2019-05-30 | | 公開日 | 2020-03-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The importance of Ile716 toward the mutagenicity of 8-Oxo-2'-deoxyguanosine with Bacillus fragment DNA polymerase.
DNA Repair (Amst.), 89, 2020
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6OYT
 | | ASK1 kinase domain in complex with GS-4997 | | 分子名称: | 5-(4-cyclopropyl-1H-imidazol-1-yl)-2-fluoro-4-methyl-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}benzamide, ACETATE ION, Mitogen-activated protein kinase kinase kinase 5 | | 著者 | Marcotte, D.J. | | 登録日 | 2019-05-15 | | 公開日 | 2019-11-27 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.824 Å) | | 主引用文献 | Rational Design and Optimization of a Novel Class of Macrocyclic Apoptosis Signal-Regulating Kinase 1 Inhibitors.
J.Med.Chem., 62, 2019
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6VRE
 | | Structure of ASK1 bound to BIO-1772961 | | 分子名称: | 3-methoxy-N-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-1-(pyrazin-2-yl)-1H-pyrazole-4-carboxamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase kinase kinase 5 | | 著者 | Chodaparambil, J.V, Marcotte, D.J. | | 登録日 | 2020-02-07 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Discovery of CNS-Penetrant Apoptosis Signal-Regulating Kinase 1 (ASK1) Inhibitors.
Acs Med.Chem.Lett., 11, 2020
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8UR5
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8UR7
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5AMV
 | | Structural insights into the loss of catalytic competence in pectate lyase at low pH | | 分子名称: | ACETATE ION, CALCIUM ION, GLYCEROL, ... | | 著者 | Teixeira, S.C.M, Ali, S, Sondergaard, C, Pickersgill, R. | | 登録日 | 2015-09-02 | | 公開日 | 2015-09-30 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Structural Insights Into the Loss of Catalytic Competence in Pectate Lyase Activity at Low Ph.
FEBS Lett., 589, 2015
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1B50
 | | NMR STRUCTURE OF HUMAN MIP-1A D26A, 10 STRUCTURES | | 分子名称: | MIP-1A | | 著者 | Waltho, J.P, Higgins, L.D, Craven, C.J, Tan, P, Dudgeon, T. | | 登録日 | 1999-01-11 | | 公開日 | 1999-07-22 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
J.Biol.Chem., 274, 1999
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6Z8L
 | | Alpha-Amylase in complex with probe fragments | | 分子名称: | CALCIUM ION, CHLORIDE ION, Pancreatic alpha-amylase, ... | | 著者 | Adam, S, Koehnke, J. | | 登録日 | 2020-06-02 | | 公開日 | 2020-12-02 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.40000367 Å) | | 主引用文献 | Enhancing glycan stability via site-selective fluorination: modulating substrate orientation by molecular design.
Chem Sci, 12, 2020
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1K6A
 | | Structural studies on the mobility in the active site of the Thermoascus aurantiacus xylanase I | | 分子名称: | xylanase I | | 著者 | Lo Leggio, L, Kalogiannis, S, Eckert, K, Teixeira, S.C.M, Bhat, M.K, Andrei, C, Pickersgill, R.W, Larsen, S. | | 登録日 | 2001-10-15 | | 公開日 | 2002-07-03 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Substrate specificity and subsite mobility in T. aurantiacus xylanase 10A.
FEBS LETT., 509, 2001
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1B53
 | | NMR STRUCTURE OF HUMAN MIP-1A D26A, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | MIP-1A | | 著者 | Waltho, J.P, Higgins, L.D, Craven, C.J, Tan, P, Dudgeon, T. | | 登録日 | 1999-01-11 | | 公開日 | 1999-07-22 | | 最終更新日 | 2021-11-03 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Identification of amino acid residues critical for aggregation of human CC chemokines macrophage inflammatory protein (MIP)-1alpha, MIP-1beta, and RANTES. Characterization of active disaggregated chemokine variants.
J.Biol.Chem., 274, 1999
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1GOM
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8A1S
 | | Structure of murine perforin-2 (Mpeg1) pore in twisted form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Macrophage-expressed gene 1 protein | | 著者 | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | 登録日 | 2022-06-02 | | 公開日 | 2022-07-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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8A1D
 | | Structure of murine perforin-2 (Mpeg1) pore in ring form | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, Macrophage-expressed gene 1 protein | | 著者 | Yu, X, Ni, T, Zhang, P, Gilbert, R. | | 登録日 | 2022-06-01 | | 公開日 | 2022-07-20 | | 最終更新日 | 2022-12-14 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures of perforin-2 in isolation and assembled on a membrane suggest a mechanism for pore formation.
Embo J., 41, 2022
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1GOK
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3HV0
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5JX8
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5JX3
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7AWK
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5JX0
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3HZR
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