8EZ4
| Plasmodium falciparum M17 in complex with inhibitor 9aa | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, N-[(1R)-2-(hydroxyamino)-2-oxo-1-(3',4',5'-trifluoro[1,1'-biphenyl]-4-yl)ethyl]-N~2~-phenylglycinamide, ... | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | 登録日 | 2022-10-31 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248, 2022
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8EZ2
| Plasmodium falciparum M1 in complex with inhibitor 15ag | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, M1 family aminopeptidase, ... | 著者 | Calic, P.P.S, McGowan, S, Webb, C.T. | 登録日 | 2022-10-31 | 公開日 | 2023-01-18 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | 主引用文献 | Structure-based development of potent Plasmodium falciparum M1 and M17 aminopeptidase selective and dual inhibitors via S1'-region optimisation. Eur.J.Med.Chem., 248, 2022
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8T6H
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7K5K
| Plasmodium vivax M17 leucyl aminopeptidase Pv-M17 | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, putative, ... | 著者 | Malcolm, T.R, McGowan, S, Belousoff, M.J. | 登録日 | 2020-09-17 | 公開日 | 2020-12-16 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (2.66 Å) | 主引用文献 | Active site metals mediate an oligomeric equilibrium in Plasmodium M17 aminopeptidases. J.Biol.Chem., 296, 2020
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2G72
| Structure of hPNMT with inhibitor 3-fluoromethyl-7-thiomorpholinosulfonamide-THIQ and AdoMet | 分子名称: | (3R)-3-(FLUOROMETHYL)-7-(THIOMORPHOLIN-4-YLSULFONYL)-1,2,3,4-TETRAHYDROISOQUINOLINE, Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Tyndall, J.D.A, Gee, C.L, Martin, J.L. | 登録日 | 2006-02-27 | 公開日 | 2007-02-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007
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2G70
| Structure of human PNMT in complex with inhibitor 3-hydroxymethyl-7-nitro-THIQ and AdoMet (SAM) | 分子名称: | PHOSPHATE ION, Phenylethanolamine N-methyltransferase, S-ADENOSYLMETHIONINE, ... | 著者 | Tyndall, J.D.A, Gee, C.L, Martin, J.L. | 登録日 | 2006-02-27 | 公開日 | 2007-02-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007
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2G71
| Structure of hPNMT with inhibitor 3-fluoromethyl-7-trifluoropropyl-THIQ and AdoHcy | 分子名称: | (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, GLYCEROL, Phenylethanolamine N-methyltransferase, ... | 著者 | Tyndall, J.D.A, Gee, C.L, Martin, J.L. | 登録日 | 2006-02-27 | 公開日 | 2007-02-13 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50, 2007
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4Z09
| Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Thr2040Ala] peptide | 分子名称: | Apical membrane antigen 1, GLYCEROL, Rhoptry neck protein 2 | 著者 | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | 登録日 | 2015-03-26 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0D
| Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038Trp] peptide | 分子名称: | Apical membrane antigen 1, Rhoptry neck protein 2 | 著者 | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | 登録日 | 2015-03-26 | 公開日 | 2016-08-03 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0E
| Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038TRN] peptide | 分子名称: | Apical membrane antigen 1, Rhoptry neck protein 2 | 著者 | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | 登録日 | 2015-03-26 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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4Z0F
| Crystal structure of FVO strain Plasmodium falciparum AMA1 in complex with the RON2hp [Phe2038(6CW)] peptide | 分子名称: | Apical membrane antigen 1, Rhoptry neck protein 2 | 著者 | Wang, G, McGowan, S, Norton, R.S, Scanlon, M.J. | 登録日 | 2015-03-26 | 公開日 | 2016-08-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure-Activity Studies of beta-Hairpin Peptide Inhibitors of the Plasmodium falciparum AMA1-RON2 Interaction. J.Mol.Biol., 428, 2016
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