7TYU
| TEAD2 bound to Compound 2 | 分子名称: | (3R)-1-[(8S)-5-(4-cyclohexylphenyl)-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonyl]pyrrolidine-3-carbonitrile, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4 | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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7TYP
| TEAD2 bound to GNE-7883 | 分子名称: | (8S)-5-(4-cyclohexylphenyl)-3-[3-(fluoromethyl)azetidine-1-carbonyl]-2-(3-methylpyrazin-2-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Transcriptional enhancer factor TEF-4 | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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7TYQ
| TEAD2 bound to Compound 1 | 分子名称: | Transcriptional enhancer factor TEF-4, ethyl (8S)-7-oxo-5-[4-(trifluoromethyl)phenyl]-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate | 著者 | Noland, C.L, Fong, R. | 登録日 | 2022-02-14 | 公開日 | 2023-05-03 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Novel mechanism of YAP-TEAD inhibition results in targeted chromatin remodeling and reveals an
expanded Hippo dependent landscape in cancers To Be Published
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5WWL
| Crystal structure of the Schizogenesis pombe kinetochore Mis12C subcomplex | 分子名称: | Centromere protein mis12, Kinetochore protein nnf1 | 著者 | Wang, C, Zhou, X, Wu, M, Zhang, X, Zang, J. | 登録日 | 2017-01-02 | 公開日 | 2017-11-15 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Phosphorylation of CENP-C by Aurora B facilitates kinetochore attachment error correction in mitosis. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6L1P
| Crystal structure of PHF20L1 in complex with Hit 1 | 分子名称: | 4-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)phenol, GLYCEROL, PHD finger protein 20-like protein 1, ... | 著者 | Lv, M.Q, Gao, J. | 登録日 | 2019-09-29 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.231 Å) | 主引用文献 | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
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6L1C
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6L1I
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6L10
| PHF20L1 Tudor1 - MES | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, PHD finger protein 20-like protein 1, SULFATE ION | 著者 | Lv, M.Q, Gao, J. | 登録日 | 2019-09-27 | 公開日 | 2020-09-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1. J Phys Chem Lett, 11, 2020
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6L1F
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5YFG
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6LBG
| Structure of OR51B2 bound FEM1C | 分子名称: | Protein fem-1 homolog C,Peptide from Olfactory receptor 51B2, SULFATE ION | 著者 | Chen, X, Liao, S, Xu, C. | 登録日 | 2019-11-14 | 公開日 | 2020-10-21 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.51 Å) | 主引用文献 | Molecular basis for arginine C-terminal degron recognition by Cul2 FEM1 E3 ligase. Nat.Chem.Biol., 17, 2021
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1SHY
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6H02
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6KMH
| The crystal structure of CASK/Mint1 complex | 分子名称: | Amyloid-beta A4 precursor protein-binding family A member 1, CHLORIDE ION, IODIDE ION, ... | 著者 | Li, W, Feng, W. | 登録日 | 2019-07-31 | 公開日 | 2020-08-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | CASK modulates the assembly and function of the Mint1/Munc18-1 complex to regulate insulin secretion. Cell Discov, 6, 2020
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2LNW
| Identification and structural basis for a novel interaction between Vav2 and Arap3 | 分子名称: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 | 著者 | Wu, B, Zhang, J, Wu, J, Shi, Y. | 登録日 | 2012-01-05 | 公開日 | 2012-11-21 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
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2LNC
| Solution NMR structure of Norwalk virus protease | 分子名称: | 3C-like protease | 著者 | Takahashi, D, Hiromasa, Y, Kim, Y, Anbanandam, A, Chang, K, Prakash, O. | 登録日 | 2011-12-22 | 公開日 | 2012-12-26 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and dynamics characterization of norovirus protease. Protein Sci., 22, 2013
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2LNX
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2MVN
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2MVM
| Solution structure of eEF1Bdelta CAR domain | 分子名称: | Elongation factor 1-delta | 著者 | Wu, H, Feng, Y. | 登録日 | 2014-10-09 | 公開日 | 2015-02-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Evolutionarily Conserved Binding of Translationally Controlled Tumor Protein to Eukaryotic Elongation Factor 1B. J.Biol.Chem., 290, 2015
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6AAX
| Crystal structure of TFB1M and h45 with SAM in homo sapiens | 分子名称: | DI(HYDROXYETHYL)ETHER, Dimethyladenosine transferase 1, mitochondrial, ... | 著者 | Liu, X, Shen, S, Wu, P, Li, F, Gong, Q, Wu, J, Zhang, H, Shi, Y. | 登録日 | 2018-07-19 | 公開日 | 2019-06-05 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.994 Å) | 主引用文献 | Structural insights into dimethylation of 12S rRNA by TFB1M: indispensable role in translation of mitochondrial genes and mitochondrial function. Nucleic Acids Res., 47, 2019
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6AAU
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5Z08
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5Z07
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8JAR
| Structure of CRL2APPBP2 bound with RxxGPAA degron (dimer) | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, Elongin-B, ... | 著者 | Zhao, S, Zhang, K, Xu, C. | 登録日 | 2023-05-07 | 公開日 | 2023-10-18 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
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8JAV
| Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer) | 分子名称: | Amyloid protein-binding protein 2, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... | 著者 | Zhao, S, Zhang, K, Xu, C. | 登録日 | 2023-05-07 | 公開日 | 2023-10-18 | 最終更新日 | 2023-10-25 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Molecular basis for C-degron recognition by CRL2 APPBP2 ubiquitin ligase. Proc.Natl.Acad.Sci.USA, 120, 2023
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