7WTE
 
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 2 | | 分子名称: | ACETYL COENZYME *A, ADENOSINE-5'-TRIPHOSPHATE, Pyruvate carboxylase, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTB
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTA
 | | Cryo-EM structure of human pyruvate carboxylase in apo state | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Pyruvate carboxylase, mitochondrial | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTD
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the intermediate state 1 | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, COENZYME A, Pyruvate carboxylase, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTC
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7CUJ
 | | Crystal structure of fission yeast Ccq1 and Tpz1 | | 分子名称: | Coiled-coil quantitatively-enriched protein 1, Protection of telomeres protein tpz1 | | 著者 | Sun, H, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2020-08-23 | | 公開日 | 2021-08-25 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.
Plos Genet., 18, 2022
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7CUH
 | | Crystal structure of fission yeast Pot1 and ssDNA | | 分子名称: | Protection of telomeres protein 1, Telomere single-strand DNA | | 著者 | Sun, H, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2020-08-23 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.
Plos Genet., 18, 2022
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7CUI
 | | Crystal structure of fission yeast Pot1 and Tpz1 | | 分子名称: | Protection of telomeres protein 1, Protection of telomeres protein tpz1, SULFATE ION | | 著者 | Sun, H, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2020-08-23 | | 公開日 | 2021-08-25 | | 最終更新日 | 2022-09-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural insights into Pot1-ssDNA, Pot1-Tpz1 and Tpz1-Ccq1 Interactions within fission yeast shelterin complex.
Plos Genet., 18, 2022
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7E34
 | | Crystal structure of SUN1-Speedy A-CDK2 | | 分子名称: | Cyclin-dependent kinase 2, GLYCEROL, SUN domain-containing protein 1, ... | | 著者 | Chen, Y, Huang, C, Wu, J, Lei, M. | | 登録日 | 2021-02-08 | | 公開日 | 2021-04-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | The SUN1-SPDYA interaction plays an essential role in meiosis prophase I.
Nat Commun, 12, 2021
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7D60
 | | Cryo-EM Structure of human CALHM5 in the presence of rubidium red | | 分子名称: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | 著者 | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | 登録日 | 2020-09-28 | | 公開日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | | 主引用文献 | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7D65
 | | Cryo-EM Structure of human CALHM5 in the presence of Ca2+ | | 分子名称: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | 著者 | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | 登録日 | 2020-09-29 | | 公開日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | | 主引用文献 | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7D61
 | | Cryo-EM Structure of human CALHM5 in the presence of EDTA | | 分子名称: | 1,2-DIOCTANOYL-SN-GLYCERO-3-PHOSPHATE, Calcium homeostasis modulator protein 5 | | 著者 | Liu, J, Guan, F.H, Wu, J, Wan, F.T, Lei, M, Ye, S. | | 登録日 | 2020-09-28 | | 公開日 | 2020-12-23 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Cryo-EM structures of human calcium homeostasis modulator 5.
Cell Discov, 6, 2020
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7X5C
 | | Solution structure of Tetrahymena p75OB1-p50PBM | | 分子名称: | Telomerase associated protein p50PBM, Telomerase-associated protein p75OB1 | | 著者 | Wu, B, Tang, T, Xue, H.J, Wu, J, Lei, M. | | 登録日 | 2022-03-04 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Association of the CST complex and p50 in Tetrahymena is crucial for telomere maintenance
Structure, 2022
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6J0W
 | | Crystal Structure of Yeast Rtt107 and Nse6 | | 分子名称: | Peptide from DNA repair protein KRE29, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J07
 | | Crystal structure of human TERB2 and TERB1 | | 分子名称: | Telomere repeats-binding bouquet formation protein 1, Telomere repeats-binding bouquet formation protein 2, ZINC ION | | 著者 | Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. | | 登録日 | 2018-12-21 | | 公開日 | 2019-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.298 Å) | | 主引用文献 | The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
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6J0V
 | | Crystal Structure of Yeast Rtt107 | | 分子名称: | Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.314 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J67
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6J0Y
 | | Crystal Structure of Yeast Rtt107 and Slx4 | | 分子名称: | Peptide from Structure-specific endonuclease subunit SLX4, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J0X
 | | Crystal Structure of Yeast Rtt107 and Mms22 | | 分子名称: | Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J08
 | | Crystal structure of human MAJIN and TERB2 | | 分子名称: | Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2 | | 著者 | Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. | | 登録日 | 2018-12-21 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
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7X9G
 | | Crystal structure of human EDA and EDAR | | 分子名称: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | | 著者 | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | | 登録日 | 2022-03-15 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.
Nat Commun, 14, 2023
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7V9A
 | | biogenesis module of human telomerase holoenzyme | | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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7V99
 | | catalytic core of human telomerase holoenzyme | | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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6BPH
 | | Crystal structure of the chromodomain of RBBP1 | | 分子名称: | AT-rich interactive domain-containing protein 4A, UNKNOWN ATOM OR ION | | 著者 | Liu, Y, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-11-23 | | 公開日 | 2017-12-20 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of chromo barrel domain of RBBP1.
Biochem. Biophys. Res. Commun., 496, 2018
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6C1Y
 | | mbd of human mecp2 in complex with methylated DNA | | 分子名称: | 12-mer DNA, Methyl-CpG-binding protein 2, UNKNOWN ATOM OR ION | | 著者 | Liu, K, Bian, C, Tempel, W, Wernimont, A.K, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2018-01-05 | | 公開日 | 2018-02-14 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Plasticity at the DNA recognition site of the MeCP2 mCG-binding domain.
Biochim Biophys Acta Gene Regul Mech, 1862, 2019
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