7WTC
 
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA in the ground state | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, Pyruvate carboxylase, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7WTB
 | | Cryo-EM structure of human pyruvate carboxylase with acetyl-CoA | | 分子名称: | 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, ACETYL COENZYME *A, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Chai, P, Lan, P, Wu, J, Lei, M. | | 登録日 | 2022-02-04 | | 公開日 | 2022-11-09 | | 最終更新日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Mechanistic insight into allosteric activation of human pyruvate carboxylase by acetyl-CoA.
Mol.Cell, 82, 2022
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7V2Y
 | | cryo-EM structure of yeast THO complex with Sub2 | | 分子名称: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2, ... | | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-10 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
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7V2W
 | | protomer structure from the dimer of yeast THO complex | | 分子名称: | Protein TEX1, THO complex subunit 2, THO complex subunit HPR1, ... | | 著者 | Chen, C, Tan, M, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-10 | | 公開日 | 2022-07-27 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural and functional insights into R-loop prevention and mRNA export by budding yeast THO-Sub2 complex.
Sci Bull (Beijing), 66, 2021
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7BU5
 | | Crystal Structure of Human SLX4 and MUS81 | | 分子名称: | GLYCINE, MUS81 endonuclease homolog (Yeast), isoform CRA_b, ... | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2020-04-04 | | 公開日 | 2021-04-07 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | SLX4 control MUS81 endonuclease function in telomere through an intermolecular SAP domain
To be published
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7X5C
 | | Solution structure of Tetrahymena p75OB1-p50PBM | | 分子名称: | Telomerase associated protein p50PBM, Telomerase-associated protein p75OB1 | | 著者 | Wu, B, Tang, T, Xue, H.J, Wu, J, Lei, M. | | 登録日 | 2022-03-04 | | 公開日 | 2022-10-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Association of the CST complex and p50 in Tetrahymena is crucial for telomere maintenance
Structure, 2022
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7X9G
 | | Crystal structure of human EDA and EDAR | | 分子名称: | Ectodysplasin-A, secreted form, Tumor necrosis factor receptor superfamily member EDAR | | 著者 | Yu, K, Wan, F, Huang, C, Wu, J, Lei, M. | | 登録日 | 2022-03-15 | | 公開日 | 2023-02-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.
Nat Commun, 14, 2023
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3CRU
 | | Structural characterization of an engineered allosteric protein | | 分子名称: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | | 著者 | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | | 登録日 | 2008-04-07 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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3CRT
 | | Structural characterization of an engineered allosteric protein | | 分子名称: | GLUTATHIONE, Glutathione S-transferase class-mu 26 kDa isozyme | | 著者 | Sagermann, M, Chapleau, R, DeLorimier, E, Lei, M. | | 登録日 | 2008-04-07 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
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7V9A
 | | biogenesis module of human telomerase holoenzyme | | 分子名称: | H/ACA ribonucleoprotein complex subunit 1, H/ACA ribonucleoprotein complex subunit 2, H/ACA ribonucleoprotein complex subunit 3, ... | | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-03-30 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3.94 Å) | | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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7V99
 | | catalytic core of human telomerase holoenzyme | | 分子名称: | Histone H2A type 1-B/E, Histone H2B type 1-K, Primer DNA, ... | | 著者 | Wan, F, Ding, Y, Yang, L, Wu, Z, Wu, J, Lei, M. | | 登録日 | 2021-08-24 | | 公開日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | | 主引用文献 | Zipper head mechanism of telomere synthesis by human telomerase.
Cell Res., 31, 2021
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7C7A
 | | Cryo-EM structure of yeast Ribonuclease MRP with substrate ITS1 | | 分子名称: | Internal Transcribed Spacer 1, MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, ... | | 著者 | Lan, P, Wu, J, Lei, M. | | 登録日 | 2020-05-24 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
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7C79
 | | Cryo-EM structure of yeast Ribonuclease MRP | | 分子名称: | MAGNESIUM ION, RNases MRP/P 32.9 kDa subunit, Ribonuclease MRP RNA subunit NME1, ... | | 著者 | Lan, P, Wu, J, Lei, M. | | 登録日 | 2020-05-24 | | 公開日 | 2020-07-08 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Structural insight into precursor ribosomal RNA processing by ribonuclease MRP.
Science, 369, 2020
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6K0B
 | | cryo-EM structure of archaeal Ribonuclease P with mature tRNA | | 分子名称: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | | 著者 | Wan, F, Lan, P, Wu, J, Lei, M. | | 登録日 | 2019-05-05 | | 公開日 | 2019-06-19 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
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6K0A
 | | cryo-EM structure of an archaeal Ribonuclease P | | 分子名称: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | | 著者 | Wan, F, Lan, P, Wu, J, Lei, M. | | 登録日 | 2019-05-05 | | 公開日 | 2019-06-19 | | 最終更新日 | 2022-12-21 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
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7D58
 | | cryo-EM structure of human RNA polymerase III in elongating state | | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | 著者 | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | | 登録日 | 2020-09-25 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
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7D59
 | | cryo-EM structure of human RNA polymerase III in apo state | | 分子名称: | DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III subunit RPC10, DNA-directed RNA polymerase III subunit RPC2, ... | | 著者 | Wang, Q, Wan, F, Lan, P, Wu, J, Lei, M. | | 登録日 | 2020-09-25 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into transcriptional regulation of human RNA polymerase III.
Nat.Struct.Mol.Biol., 28, 2021
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3DBQ
 | | Crystal structure of TTK kinase domain | | 分子名称: | Dual specificity protein kinase TTK | | 著者 | Wang, W, Yang, Y.T, Gao, Y.F, Zhu, S.C, Wang, F, Old, W, Xu, Q.B, Resing, K, Ahn, N, Lei, M, Liu, X.D. | | 登録日 | 2008-06-02 | | 公開日 | 2009-02-10 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural and Mechanistic Insights into Mps1 Kinase Activation
J.CELL.MOL.MED., 13, 2008
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6J0W
 | | Crystal Structure of Yeast Rtt107 and Nse6 | | 分子名称: | Peptide from DNA repair protein KRE29, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J07
 | | Crystal structure of human TERB2 and TERB1 | | 分子名称: | Telomere repeats-binding bouquet formation protein 1, Telomere repeats-binding bouquet formation protein 2, ZINC ION | | 著者 | Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. | | 登録日 | 2018-12-21 | | 公開日 | 2019-02-27 | | 実験手法 | X-RAY DIFFRACTION (3.298 Å) | | 主引用文献 | The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
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6J0V
 | | Crystal Structure of Yeast Rtt107 | | 分子名称: | Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.314 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J67
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6J0Y
 | | Crystal Structure of Yeast Rtt107 and Slx4 | | 分子名称: | Peptide from Structure-specific endonuclease subunit SLX4, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J0X
 | | Crystal Structure of Yeast Rtt107 and Mms22 | | 分子名称: | Peptide from E3 ubiquitin-protein ligase substrate receptor MMS22, Regulator of Ty1 transposition protein 107 | | 著者 | Wan, B, Wu, J, Lei, M. | | 登録日 | 2018-12-27 | | 公開日 | 2019-08-14 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.
Mol.Cell, 75, 2019
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6J08
 | | Crystal structure of human MAJIN and TERB2 | | 分子名称: | Membrane-anchored junction protein, Telomere repeats-binding bouquet formation protein 2 | | 著者 | Wang, Y, Chen, Y, Wu, J, Huang, C, Lei, M. | | 登録日 | 2018-12-21 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope.
Nat Commun, 10, 2019
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