7XF5
 
 | | Full length human CLC-2 channel in apo state | | 分子名称: | Chloride channel protein 2 | | 著者 | Wang, L. | | 登録日 | 2022-04-01 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
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7XMK
 | | Crystal structure of human RIPK1 kinase domain in complex with compound SKLB923 | | 分子名称: | 5-[2-(cyclopropylcarbonylamino)-[1,2,4]triazolo[1,5-a]pyridin-7-yl]-N-[(1S)-1-(3-fluorophenyl)ethyl]-1-methyl-indole-3-carboxamide, IODIDE ION, Receptor-interacting serine/threonine-protein kinase 1 | | 著者 | Zhang, L, Wang, Y, Li, Y, Yang, S. | | 登録日 | 2022-04-26 | | 公開日 | 2023-04-26 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (2.376 Å) | | 主引用文献 | From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases.
J.Med.Chem., 67, 2024
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7XJA
 | | TMD masked refine map of human ClC-2 | | 分子名称: | Chloride channel protein 2 | | 著者 | Wang, L. | | 登録日 | 2022-04-15 | | 公開日 | 2023-05-17 | | 最終更新日 | 2023-11-15 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42
Nat Commun, 14, 2023
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3DO4
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1FVQ
 | | SOLUTION STRUCTURE OF THE YEAST COPPER TRANSPORTER DOMAIN CCC2A IN THE APO AND CU(I) LOADED STATES | | 分子名称: | COPPER-TRANSPORTING ATPASE | | 著者 | Banci, L, Bertini, I, Ciofi Baffoni, S, Huffman, D.L, O'Halloran, T.V. | | 登録日 | 2000-09-20 | | 公開日 | 2001-03-14 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the yeast copper transporter domain Ccc2a in the apo and Cu(I)-loaded states.
J.Biol.Chem., 276, 2001
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1FZJ
 | | MHC CLASS I NATURAL MUTANT H-2KBM1 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Rudolph, M.G, Speir, J.A, Brunmark, A, Mattsson, N, Jackson, M.R, Peterson, P.A, Teyton, L, Wilson, I.A. | | 登録日 | 2000-10-03 | | 公開日 | 2001-03-28 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
Immunity, 14, 2001
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3M6D
 | | The crystal structure of the d307a mutant of glycoside Hydrolase (family 31) from ruminococcus obeum atcc 29174 | | 分子名称: | Uncharacterized protein | | 著者 | Tan, K, Tesar, C, Freeman, L, Babnigg, G, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2010-03-15 | | 公開日 | 2010-04-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Novel alpha-glucosidase from human gut microbiome: substrate specificities and their switch.
Faseb J., 24, 2010
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7YE9
 | | SARS-CoV-2 Spike (6P) in complex with 3 R1-32 Fabs | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of R1-32 Fab, ... | | 著者 | Liu, B, Gao, X, Li, Z, Chen, X, He, J, Chen, L, Xiong, X. | | 登録日 | 2022-07-05 | | 公開日 | 2022-08-24 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (4.17 Å) | | 主引用文献 | SARS-CoV-2 Delta and Omicron variants evade population antibody response by mutations in a single spike epitope.
Nat Microbiol, 7, 2022
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1EVF
 | | CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI | | 分子名称: | SULFATE ION, THYMIDYLATE SYNTHASE | | 著者 | Phan, J, Mahdavian, E, Nivens, M.C, Minor, W, Berger, S, Spencer, H.T, Dunlap, R.B, Lebioda, L. | | 登録日 | 2000-04-19 | | 公開日 | 2000-05-03 | | 最終更新日 | 2022-04-13 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Biochemistry, 39, 2000
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1EWA
 | | Dehaloperoxidase and 4-iodophenol | | 分子名称: | 4-IODOPHENOL, DEHALOPEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | LaCount, M.W, Zhang, E, Chen, Y.P, Han, K, Whitton, M.M, Lincoln, D.E, Woodin, S.A, Lebioda, L. | | 登録日 | 2000-04-24 | | 公開日 | 2000-05-10 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | The crystal structure and amino acid sequence of dehaloperoxidase from Amphitrite ornata indicate common ancestry with globins
J.Biol.Chem., 275, 2000
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1EEQ
 | | M4L/Y(27D)D/T94H Mutant of LEN | | 分子名称: | KAPPA-4 IMMUNOGLOBULIN (LIGHT CHAIN) | | 著者 | Pokkuluri, P.R, Raffen, R, Dieckman, L, Boogaard, C, Stevens, F.J, Schiffer, M. | | 登録日 | 2000-02-01 | | 公開日 | 2001-02-01 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Increasing protein stability by polar surface residues: domain-wide consequences of interactions within a loop.
Biophys.J., 82, 2002
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1EF7
 | | CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X | | 分子名称: | CATHEPSIN X | | 著者 | Guncar, G, Klemencic, I, Turk, B, Turk, V, Karaoglanovic-Carmona, A, Juliano, L, Turk, D. | | 登録日 | 2000-02-07 | | 公開日 | 2000-03-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.67 Å) | | 主引用文献 | Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Structure Fold.Des., 8, 2000
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7D42
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7D6H
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1EVV
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1EWZ
 | | CRYSTAL STRUCTURE OF THE OXA-10 BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA | | 分子名称: | BETA LACTAMASE OXA-10 | | 著者 | Golemi, D, Maveyraud, L, Vakulenko, S, Tranier, S, Ishiwata, A, Kotra, L.P, Samama, J.P, Mobashery, S. | | 登録日 | 2000-04-28 | | 公開日 | 2000-11-01 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics
J.Am.Chem.Soc., 122, 2000
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1GBR
 | | ORIENTATION OF PEPTIDE FRAGMENTS FROM SOS PROTEINS BOUND TO THE N-TERMINAL SH3 DOMAIN OF GRB2 DETERMINED BY NMR SPECTROSCOPY | | 分子名称: | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, SOS-A PEPTIDE | | 著者 | Wittekind, M, Mapelli, C, Farmer, B.T, Suen, K.-L, Goldfarb, V, Tsao, J, Lavoie, T, Barbacid, M, Meyers, C.A, Mueller, L. | | 登録日 | 1994-08-12 | | 公開日 | 1995-01-26 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Orientation of peptide fragments from Sos proteins bound to the N-terminal SH3 domain of Grb2 determined by NMR spectroscopy.
Biochemistry, 33, 1994
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1GJS
 | | Solution structure of the Albumin binding domain of Streptococcal Protein G | | 分子名称: | IMMUNOGLOBULIN G BINDING PROTEIN G | | 著者 | Johansson, M.U, Frick, I.M, Nilsson, H, Kraulis, P.J, Hober, S, Jonasson, P, Nygren, A.P, Uhlen, M, Bjorck, L, Drakenberg, T, Forsen, S, Wikstrom, M. | | 登録日 | 2001-08-02 | | 公開日 | 2001-08-09 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure, Specificity, and Mode of Interaction for Bacterial Albumin-Binding Modules
J.Biol.Chem., 277, 2002
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1FZO
 | | MHC CLASS I NATURAL MUTANT H-2KBM8 HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND SENDAI VIRUS NUCLEOPROTEIN | | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Rudolph, M.G, Speir, J.A, Brunmark, A, Mattsson, N, Jackson, M.R, Peterson, P.A, Teyton, L, Wilson, I.A. | | 登録日 | 2000-10-03 | | 公開日 | 2001-03-28 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity.
Immunity, 14, 2001
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1G00
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1GMY
 | | Cathepsin B complexed with dipeptidyl nitrile inhibitor | | 分子名称: | 2-AMINOETHANIMIDIC ACID, 3-METHYLPHENYLALANINE, CATHEPSIN B, ... | | 著者 | Greenspan, P.D, Clark, K.L, Tommasi, R.A, Cowen, S.D, McQuire, L.W, Farley, D.L, van Duzer, J.H, Goldberg, R.L, Zhou, H, Du, Z, Fitt, J.J, Coppa, D.E, Fang, Z, Macchia, W, Zhu, L, Capparelli, M.P, Goldstein, R, Wigg, A.M, Doughty, J.R, Bohacek, R.S, Knap, A.K. | | 登録日 | 2001-09-25 | | 公開日 | 2002-09-19 | | 最終更新日 | 2017-07-05 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design
J.Med.Chem., 44, 2001
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1G98
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7XSR
 | | Structure of Craspase-target RNA | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | | 著者 | Feng, Y, Zhang, L. | | 登録日 | 2022-05-15 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | | 主引用文献 | Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
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7XSQ
 | | Structure of the Craspase | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | | 著者 | Feng, Y, Zhang, L. | | 登録日 | 2022-05-15 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
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7XT4
 | | Structure of Craspase-NTR | | 分子名称: | CHAT domain protein, RAMP superfamily protein, RNA (34-MER), ... | | 著者 | Feng, Y, Zhang, L. | | 登録日 | 2022-05-16 | | 公開日 | 2022-11-09 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | | 主引用文献 | Target RNA activates the protease activity of Craspase to confer antiviral defense.
Mol.Cell, 82, 2022
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