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6U9R
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BU of 6u9r by Molmil
MLL1 SET N3861I/Q3867L bound to inhibitor 12 (TC-5140)
分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(3-chlorophenyl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, Histone-lysine N-methyltransferase, ZINC ION
著者Petrunak, E.M, Stuckey, J.A.
登録日2019-09-09
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
5XZR
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BU of 5xzr by Molmil
The atomic structure of SHP2 E76A mutant in complex with allosteric inhibitor 9b
分子名称: 4-(3-phenylphenyl)-N-(2,2,6,6-tetramethylpiperidin-4-yl)-1,3-thiazol-2-amine, Tyrosine-protein phosphatase non-receptor type 11
著者Li, D, Xie, J, Zhu, J, Liu, C.
登録日2017-07-13
公開日2017-12-13
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment.
J. Med. Chem., 60, 2017
5YKG
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BU of 5ykg by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2024-11-13
実験手法ELECTRON MICROSCOPY (4.57 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YDP
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BU of 5ydp by Molmil
Crystal Structure of TetR Family Repressor AlkX from Dietzia sp. Strain DQ12-45-1b Implicated in Biodegradation of n-Alkanes
分子名称: TetR transcriptional regulatory protein
著者Zheng, H, Gao, Y, Liang, J.L.
登録日2017-09-14
公開日2017-10-04
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.091 Å)
主引用文献Crystal Structure of TetR Family Repressor AlkX from Dietzia sp. Strain DQ12-45-1b Implicated in Biodegradation ofn-Alkanes.
Appl. Environ. Microbiol., 83, 2017
8JLX
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BU of 8jlx by Molmil
CCHFV envelope protein Gc in complex with Gc13
分子名称: Glycoprotein C,CCHFV Gc fusion loops, Mouse antibody Gc13 heavy chain, Mouse antibody Gc13 light chain
著者Chong, T, Cao, S.
登録日2023-06-03
公開日2024-01-24
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus.
Plos Pathog., 20, 2024
5YBI
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BU of 5ybi by Molmil
Structure of the bacterial pathogens ATPase with substrate AMPPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Probable ATP synthase SpaL/MxiB, ...
著者Mu, Z.X, Gao, X.P, Cui, S.
登録日2017-09-05
公開日2018-06-20
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.268 Å)
主引用文献Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase FromShigella flexneri.
Front Microbiol, 9, 2018
5YKE
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BU of 5yke by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
分子名称: 5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
著者Chen, L, Wu, J.X.
登録日2017-10-14
公開日2018-04-18
最終更新日2024-11-20
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
6U9M
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BU of 6u9m by Molmil
MLL1 SET N3861I/Q3867L bound to inhibitor 16 (TC-5109)
分子名称: 5'-{[(3S)-3-amino-3-carboxypropyl]({1-[(thiophen-2-yl)methyl]azetidin-3-yl}methyl)amino}-5'-deoxyadenosine, GLYCEROL, Histone-lysine N-methyltransferase, ...
著者Petrunak, E.M, Stuckey, J.A.
登録日2019-09-09
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
Acs Med.Chem.Lett., 11, 2020
5YTX
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BU of 5ytx by Molmil
Crystal structure of YB1 cold-shock domain in complex with UCAACU
分子名称: Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*AP*CP*U)-3')
著者Yang, X, Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.551 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019
8JSL
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BU of 8jsl by Molmil
The structure of EBOV L-VP35-RNA complex
分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV, ...
著者Qi, P, Yi, S.
登録日2023-06-20
公開日2023-09-27
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Molecular mechanism of de novo replication by the Ebola virus polymerase.
Nature, 622, 2023
8JSM
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BU of 8jsm by Molmil
The structure of EBOV L-VP35-RNA complex (conformation 1)
分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV genome., ...
著者Qi, P, Yi, S.
登録日2023-06-20
公開日2023-09-27
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Molecular mechanism of de novo replication by the Ebola virus polymerase.
Nature, 622, 2023
8JSN
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BU of 8jsn by Molmil
The structure of EBOV L-VP35-RNA complex (conformation 2)
分子名称: Polymerase cofactor VP35, RNA-directed RNA polymerase L, The leader sequence of EBOV genome, ...
著者Qi, P, Yi, S.
登録日2023-06-20
公開日2023-09-27
最終更新日2023-11-01
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Molecular mechanism of de novo replication by the Ebola virus polymerase.
Nature, 622, 2023
5YTT
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BU of 5ytt by Molmil
Crystal structure of YB1 cold-shock domain in complex with UCAUGU
分子名称: Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*GP*U)-3'), SULFATE ION
著者Yang, X, Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019
5YTV
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BU of 5ytv by Molmil
Crystal structure of YB1 cold-shock domain in complex with UCAUCU
分子名称: Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*UP*CP*AP*UP*CP*U)-3')
著者Yang, X, Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019
5YTS
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BU of 5yts by Molmil
Crystal structure of YB1 cold-shock domain in complex with UCUUCU
分子名称: Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*CP*UP*UP*C)-3'), SULFATE ION
著者Yang, X, Huang, Y.
登録日2017-11-20
公開日2018-12-05
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Crystal structure of a Y-box binding protein 1 (YB-1)-RNA complex reveals key features and residues interacting with RNA.
J.Biol.Chem., 294, 2019
5YW9
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BU of 5yw9 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2024-11-06
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWC
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BU of 5ywc by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2024-10-16
実験手法ELECTRON MICROSCOPY (4.3 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YWB
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BU of 5ywb by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-30
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (5.2 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5YW8
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BU of 5yw8 by Molmil
Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
分子名称: ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
著者Chen, L, Wu, J.X.
登録日2017-11-29
公開日2018-05-02
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels.
Protein Cell, 9, 2018
5ZT1
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BU of 5zt1 by Molmil
Structure of the bacterial pathogens ATPase with substrate ATP gamma S
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Probable ATP synthase SpaL/MxiB, ...
著者Gao, X.P, Mu, Z.X, Cui, S.
登録日2018-05-01
公開日2018-05-16
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (3.114 Å)
主引用文献Structural Insight Into Conformational Changes Induced by ATP Binding in a Type III Secretion-Associated ATPase FromShigella flexneri
Front Microbiol, 9, 2018
8JLW
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BU of 8jlw by Molmil
CCHFV envelope protein Gc in complex with Gc8
分子名称: Glycoprotein C,CCHFV envelope protein Gc fusion loops, Mouse antibody Gc8 heavy chain, Mouse antibody Gc8 light chain
著者Chong, T, Cao, S.
登録日2023-06-03
公開日2024-01-24
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Neutralizing monoclonal antibodies against the Gc fusion loop region of Crimean-Congo hemorrhagic fever virus.
Plos Pathog., 20, 2024
6WAA
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BU of 6waa by Molmil
K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one)
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one, CHLORIDE ION, ...
著者Noeske, J, Shu, W, Bellamacina, C.
登録日2020-03-24
公開日2020-07-15
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J.Med.Chem., 63, 2020
8J6T
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BU of 8j6t by Molmil
Cryo-EM structure of the double CAF-1 bound right-handed Di-tetrasome
分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者Liu, C.P, Yu, Z.Y, Xu, R.M.
登録日2023-04-26
公開日2023-08-16
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (6.6 Å)
主引用文献Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
8J6S
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BU of 8j6s by Molmil
Cryo-EM structure of the single CAF-1 bound right-handed Di-tetrasome
分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者Liu, C.P, Yu, Z.Y, Xu, R.M.
登録日2023-04-26
公開日2023-08-16
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
8IQF
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BU of 8iqf by Molmil
Cryo-EM structure of the dimeric human CAF1-H3-H4 complex
分子名称: Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ...
著者Liu, C.P, Yu, Z.Y, Xu, R.M.
登録日2023-03-16
公開日2023-08-16
最終更新日2023-09-06
実験手法ELECTRON MICROSCOPY (4.6 Å)
主引用文献Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023

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