7BX8
 
 | | Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in symmetric "resting state" | | 分子名称: | Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein | | 著者 | Gao, R.G, Zhang, L, Wang, Q, Rao, Z.H. | | 登録日 | 2020-04-17 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Protein Cell, 11, 2020
|
|
7BWR
 | | Mycobacterium smegmatis arabinosyltransferase complex EmbB2-AcpM2 in substrate DPA bound asymmetric "active state" | | 分子名称: | CALCIUM ION, Integral membrane indolylacetylinositol arabinosyltransferase EmbB, Meromycolate extension acyl carrier protein, ... | | 著者 | Gao, R.G, Zhang, L, Wang, Q, Rao, Z.H. | | 登録日 | 2020-04-15 | | 公開日 | 2020-05-27 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Cryo-EM snapshots of mycobacterial arabinosyltransferase complex EmbB2-AcpM2.
Protein Cell, 11, 2020
|
|
1Q3H
 | | mouse CFTR NBD1 with AMP.PNP | | 分子名称: | ACETIC ACID, Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, ... | | 著者 | Lewis, H.A, Buchanan, S.G, Burley, S.K, Conners, K, Dickey, M, Dorwart, M, Fowler, R, Gao, X, Guggino, W.B, Hendrickson, W.A. | | 登録日 | 2003-07-29 | | 公開日 | 2003-12-09 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
|
|
1R0Z
 | | Phosphorylated Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain one (NBD1) with ATP | | 分子名称: | ACETIC ACID, ADENOSINE-5'-TRIPHOSPHATE, Cystic fibrosis transmembrane conductance regulator, ... | | 著者 | Lewis, H.A, Buchanan, S.G, Burley, S.K, Conners, K, Dickey, M, Dorwart, M, Fowler, R, Gao, X, Guggino, W.B, Hendrickson, W.A. | | 登録日 | 2003-09-23 | | 公開日 | 2003-12-09 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator.
Embo J., 23, 2004
|
|
6L1T
 | | Cryo-EM structure of phosphorylated Tyr39 a-synuclein amyloid fibril | | 分子名称: | Alpha-synuclein | | 著者 | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | | 登録日 | 2019-09-30 | | 公開日 | 2020-08-12 | | 最終更新日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6L1U
 | | Cryo-EM structure of phosphorylated Tyr39 alpha-synuclein amyloid fibril | | 分子名称: | Alpha-synuclein | | 著者 | Liu, C, Li, Y.M, Zhao, K, Lim, Y.J, Liu, Z.Y. | | 登録日 | 2019-09-30 | | 公開日 | 2020-08-12 | | 最終更新日 | 2020-09-02 | | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | | 主引用文献 | Parkinson's disease-related phosphorylation at Tyr39 rearranges alpha-synuclein amyloid fibril structure revealed by cryo-EM.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
8YET
 | | Cryo EM structure of human phosphate channel XPR1 in complex with IP6 | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-23 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.16 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
9IWS
 | | Cryo EM structure of human phosphate channel XPR1 in complex with IP7 | | 分子名称: | (1r,2R,3S,4s,5R,6S)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-07-25 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YEX
 | | Cryo EM structure of human phosphate channel XPR1 at apo state | | 分子名称: | Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-23 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.68 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YF4
 | | Cryo EM structure of human phosphate channel XPR1 at open and inward-facing state | | 分子名称: | CHOLESTEROL HEMISUCCINATE, Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-24 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YFD
 | | Cryo EM structure of human phosphate channel XPR1 at open state | | 分子名称: | Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-24 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YFU
 | | Cryo EM structure of human phosphate channel XPR1 at intermediate state | | 分子名称: | Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-25 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.59 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YFX
 | | Cryo EM structure of human phosphate channel XPR1 at inward-facing state | | 分子名称: | Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-25 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.56 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
8YFW
 | | Cryo EM structure of human phosphate channel XPR1 at intermediate state | | 分子名称: | Solute carrier family 53 member 1 | | 著者 | Lu, Y, Yue, C, Zhang, L, Yao, D, Yu, Y, Cao, Y. | | 登録日 | 2024-02-25 | | 公開日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.65 Å) | | 主引用文献 | Structural basis for inositol pyrophosphate gating of the phosphate channel XPR1.
Science, 2024
|
|
5EDS
 | | Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5 | | 分子名称: | 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | | 著者 | Whittington, D.A, Tang, J, Yakowec, P. | | 登録日 | 2015-10-21 | | 公開日 | 2015-12-30 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K delta Inhibitors.
J.Med.Chem., 59, 2016
|
|
7X3L
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044 | | 分子名称: | (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | | 登録日 | 2022-03-01 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
|
|
7X3M
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045 | | 分子名称: | (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H. | | 登録日 | 2022-03-01 | | 公開日 | 2023-03-08 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.694 Å) | | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
|
|
5LYY
 | | Fragment-based inhibitors of Lipoprotein associated Phospholipase A2 | | 分子名称: | 3-[2-(4-fluoranylphenoxy)ethyl]-1,3-diazaspiro[4.5]decane-2,4-dione, Platelet-activating factor acetylhydrolase | | 著者 | Woolford, A, Day, P. | | 登録日 | 2016-09-29 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | | 主引用文献 | Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).
J. Med. Chem., 59, 2016
|
|
4RTH
 | | The crystal structure of PsbP from Zea mays | | 分子名称: | Membrane-extrinsic protein of photosystem II PsbP | | 著者 | Cao, P, Xie, Y, Li, M, Pan, X.W, Zhang, H.M, Zhao, X.L, Su, X.D, Cheng, T, Chang, W. | | 登録日 | 2014-11-15 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change.
Mol Plant, 8, 2015
|
|
4RTI
 | | The crystal structure of PsbP from Spinacia oleracea | | 分子名称: | CHLORIDE ION, MANGANESE (II) ION, Oxygen-evolving enhancer protein 2, ... | | 著者 | Cao, P, Xie, Y, Li, M, Pan, X.W, Zhang, H.M, Zhao, X.L, Su, X.D, Cheng, T, Chang, W. | | 登録日 | 2014-11-15 | | 公開日 | 2015-03-11 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure analysis of extrinsic PsbP protein of photosystem II reveals a manganese-induced conformational change.
Mol Plant, 8, 2015
|
|
8I4W
 | | Cryo-EM structure of 5-subunit Smc5/6 head region | | 分子名称: | DNA repair protein KRE29, Non-structural maintenance of chromosome element 5, Structural maintenance of chromosomes protein 5, ... | | 著者 | Qian, L, Jun, Z, Xiang, Z, Zhaoning, W, Cheng, T, Duo, J, Zhenguo, C, Wang, L. | | 登録日 | 2023-01-21 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (6.01 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
8I21
 | | Cryo-EM structure of 6-subunit Smc5/6 arm region | | 分子名称: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, Structural maintenance of chromosomes protein 6 | | 著者 | Jun, Z, Qian, L, Xiang, Z, Tong, C, Zhaoning, W, Duo, J, Zhenguo, C, Lanfeng, W. | | 登録日 | 2023-01-13 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (6.02 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
8I4V
 | | Cryo-EM structure of 5-subunit Smc5/6 arm region | | 分子名称: | DNA repair protein KRE29, E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, ... | | 著者 | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Zhenguo, C, Wang, L. | | 登録日 | 2023-01-21 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (5.97 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
8I4X
 | | Cryo-EM structure of 5-subunit Smc5/6 | | 分子名称: | E3 SUMO-protein ligase MMS21, Non-structural maintenance of chromosome element 5, Nse6, ... | | 著者 | Qian, L, Jun, Z, Xiang, Z, Zhaoning, W, Tong, C, Duo, J, Zhenguo, C, Wang, L. | | 登録日 | 2023-01-21 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
8I13
 | | Cryo-EM structure of 6-subunit Smc5/6 | | 分子名称: | MMS21 isoform 1, NSE3 isoform 1, Non-structural maintenance of chromosomes element 1 homolog, ... | | 著者 | Qian, L, Jun, Z, Xiang, Z, Cheng, T, Zhaoning, W, Duo, J, Zhenguo, C, Wang, L. | | 登録日 | 2023-01-12 | | 公開日 | 2024-06-26 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | Cryo-EM structures of Smc5/6 in multiple states reveal its assembly and functional mechanisms.
Nat.Struct.Mol.Biol., 2024
|
|
