7ECV
 
 | | The Csy-AcrIF14 complex | | 分子名称: | AcrIF14, CRISPR type I-F/YPEST-associated protein Csy2, CRISPR-associated protein Csy3, ... | | 著者 | Zhang, L.X, Feng, Y. | | 登録日 | 2021-03-13 | | 公開日 | 2021-11-17 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | | 主引用文献 | Insights into the dual functions of AcrIF14 during the inhibition of type I-F CRISPR-Cas surveillance complex.
Nucleic Acids Res., 49, 2021
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7DU0
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3HXA
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5DEW
 | | Crystal structure of PAK1 in complex with an inhibitor compound 5 | | 分子名称: | 8-[(trans-4-aminocyclohexyl)methyl]-6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-2-(ethylamino)pyrido[2,3-d]pyrimidin-7(8H)-one, Serine/threonine-protein kinase PAK 1 | | 著者 | Oh, A, Tam, C, Wang, W. | | 登録日 | 2015-08-26 | | 公開日 | 2016-09-21 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design of Selective PAK1 Inhibitor G-5555: Improving Proper-ties by Employing an Unorthodox Low-pKa Polar Moiety
To Be Published
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7D9Q
 | | Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 7 | | 分子名称: | (2S)-2-[[4-fluoranyl-1-[(3-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase | | 著者 | Liu, Q.F, Yin, W.C. | | 登録日 | 2020-10-14 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | | 主引用文献 | Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
J.Med.Chem., 64, 2021
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7D9P
 | | Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 12 | | 分子名称: | (2S)-2-[[4-fluoranyl-1-[(2-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase | | 著者 | Liu, Q.F, Yin, W.C. | | 登録日 | 2020-10-14 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
J.Med.Chem., 64, 2021
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7D9O
 | | Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with Compound 2 | | 分子名称: | (2R)-2-[[4-fluoranyl-1-[(4-fluorophenyl)methyl]piperidin-4-yl]methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase | | 著者 | Liu, Q.F, Yin, W.C. | | 登録日 | 2020-10-14 | | 公開日 | 2021-08-25 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.
J.Med.Chem., 64, 2021
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7V59
 | | Cryo-EM structure of spyCas9-sgRNA-DNA dimer | | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, DNA (49-MER), RNA (115-MER) | | 著者 | Liu, J, Deng, P. | | 登録日 | 2021-08-16 | | 公開日 | 2022-08-17 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (5.26 Å) | | 主引用文献 | Nonspecific interactions between SpCas9 and dsDNA sites located downstream of the PAM mediate facilitated diffusion to accelerate target search.
Chem Sci, 12, 2021
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7W9M
 | | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, ProTx-II and tetrodotoxin (S6IV pi helix conformer) | | 分子名称: | (1R,5R,6R,7R,9S,11S,12S,13S,14S)-3-amino-14-(hydroxymethyl)-8,10-dioxa-2,4-diazatetracyclo[7.3.1.1~7,11~.0~1,6~]tetradec-3-ene-5,9,12,13,14-pentol (non-preferred name), 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | | 登録日 | 2021-12-10 | | 公開日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
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7W9P
 | | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV pi helix conformer) | | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | | 登録日 | 2021-12-10 | | 公開日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
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7W9L
 | | Cryo-EM structure of human Nav1.7(E406K)-beta1-beta2 complex | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | | 登録日 | 2021-12-10 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
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7WS2
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 510A5 heavy chain, 510A5 light chain, Spike protein S1 | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS8
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7W9T
 | | Cryo-EM structure of human Nav1.7(E406K) in complex with auxiliary beta subunits, huwentoxin-IV and saxitoxin (S6IV alpha helix conformer) | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Yan, N, Huang, G, Liu, D, Wei, P. | | 登録日 | 2021-12-10 | | 公開日 | 2022-05-25 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
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7WS0
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS6
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 510A5 heavy chain, 510A5 light chain, Spike protein S1 | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WSA
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1 | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS7
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, 510A5 light chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS9
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS4
 | | Ultrapotent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS3
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7WS5
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7W9K
 | | Cryo-EM structure of human Nav1.7-beta1-beta2 complex at 2.2 angstrom resolution | | 分子名称: | (2S,3R,4E)-2-(acetylamino)-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | | 著者 | Yan, N, Huang, G, Liu, D, Wei, P, Shen, H. | | 登録日 | 2021-12-09 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (2.2 Å) | | 主引用文献 | High-resolution structures of human Na v 1.7 reveal gating modulation through alpha-pi helical transition of S6 IV.
Cell Rep, 39, 2022
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7WS1
 | | Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 510A5 heavy chain, ... | | 著者 | Guo, H, Gao, Y, Ji, X, Yang, H. | | 登録日 | 2022-01-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
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7EW1
 | | Cryo-EM structure of siponimod -bound Sphingosine-1-phosphate receptor 5 in complex with Gi protein | | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Yuan, Y, Jia, G.W, Shao, Z.H, Su, Z.M. | | 登録日 | 2021-05-24 | | 公開日 | 2021-09-29 | | 最終更新日 | 2022-02-16 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition.
Cell Res., 31, 2021
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