8HEU
 
 | | C12 portal in HCMV A-capsid | | 分子名称: | Portal protein | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-26 | | 最終更新日 | 2025-06-25 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
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8HEV
 | | C12 portal in HCMV B-capsid | | 分子名称: | Portal protein, Unknown peptide | | 著者 | Li, Z, Yu, X. | | 登録日 | 2022-11-08 | | 公開日 | 2023-04-26 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Cryo-electron microscopy structures of capsids and in situ portals of DNA-devoid capsids of human cytomegalovirus.
Nat Commun, 14, 2023
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7DPV
 | | SARS-CoV-2 3CL protease (3CLpro) in complex with 7-O-methyl-dihydromyricetin | | 分子名称: | (2S,3S)-3,5-dihydroxy-7-methoxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one, 3C-like proteinase | | 著者 | Su, H.X, Zhao, W.F, Xie, H, Li, M.J, Xu, Y.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease.
Nat Commun, 12, 2021
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7DPP
 | | SARS-CoV-2 3CL protease (3CLpro) in complex with myricetin | | 分子名称: | 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, 3C-like proteinase | | 著者 | Su, H.X, Zhao, W.F, Xie, H, Li, M.J, Xu, Y.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-05-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease.
Nat Commun, 12, 2021
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7DPU
 | | SARS-CoV-2 3CL protease (3CLpro) in complex with 7-O-methyl-myricetin | | 分子名称: | 3C-like proteinase, 7-methoxy-3,5-bis(oxidanyl)-2-[3,4,5-tris(oxidanyl)phenyl]chromen-4-one, GLYCEROL | | 著者 | Su, H.X, Zhao, W.F, Xie, H, Li, M.J, Xu, Y.C. | | 登録日 | 2020-12-21 | | 公開日 | 2021-05-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease.
Nat Commun, 12, 2021
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8YSF
 | | MERS-CoV RBD in complex with nanobody Nb9 | | 分子名称: | Nb9, Spike glycoprotein | | 著者 | Wang, Y.X, Ma, S. | | 登録日 | 2024-03-22 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain.
Plos Pathog., 20, 2024
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8YSH
 | | MERS-CoV RBD in complex with nanobody Nb14 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Nb14, Spike glycoprotein, ... | | 著者 | Wang, Y.X, Ma, S. | | 登録日 | 2024-03-23 | | 公開日 | 2024-09-11 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain.
Plos Pathog., 20, 2024
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7D3Y
 | | Crystal structure of the osPHR2-osSPX2 complex | | 分子名称: | INOSITOL HEXAKISPHOSPHATE, Protein PHOSPHATE STARVATION RESPONSE 2, SPX domain-containing protein 2,Isoform 1 of Core histone macro-H2A.1 | | 著者 | Zhang, Q.X, Guan, Z.Y, Zuo, J.Q, Zhang, Z.F, Liu, Z. | | 登録日 | 2020-09-21 | | 公開日 | 2021-10-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex.
Nat Commun, 13, 2022
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7D3T
 | | Crystal structure of OSPHR2 in complex with DNA | | 分子名称: | DNA (5'-D(P*CP*TP*CP*GP*GP*AP*TP*AP*TP*CP*CP*TP*CP*AP*AP*G)-3'), DNA (5'-D(P*GP*CP*TP*TP*GP*AP*GP*GP*AP*TP*AP*TP*CP*CP*GP*A)-3'), Protein PHOSPHATE STARVATION RESPONSE 2 | | 著者 | Guan, Z.Y, Zhang, Z.F, Liu, Z. | | 登録日 | 2020-09-20 | | 公開日 | 2021-10-06 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanistic insights into the regulation of plant phosphate homeostasis by the rice SPX2 - PHR2 complex.
Nat Commun, 13, 2022
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7V26
 | | XG005-bound SARS-CoV-2 S | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, XG005 Heavy chain, ... | | 著者 | Zhan, W.Q, Zhang, X, Sun, L, Chen, Z.G. | | 登録日 | 2021-08-07 | | 公開日 | 2021-10-20 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | | 主引用文献 | An ultrapotent pan-beta-coronavirus lineage B ( beta-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope.
Protein Cell, 13, 2022
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7YFJ
 | | Crystal structure of human WTAP | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Pre-mRNA-splicing regulator WTAP | | 著者 | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | | 登録日 | 2022-07-08 | | 公開日 | 2023-01-25 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | AI-empowered integrative structural characterization of m 6 A methyltransferase complex.
Cell Res., 32, 2022
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7CU5
 | | N-Glycosylation of PD-1 and glycosylation dependent binding of PD-1 specific monoclonal antibody camrelizumab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Programmed cell death protein 1, ... | | 著者 | Liu, K.F, Tan, S.G, Jin, W.J, Guan, J.W, Wang, W.L, Sun, H, Qi, J.X, Yan, J.H, Chai, Y, Wang, Z.F, Chu, X.D, Gao, G.F. | | 登録日 | 2020-08-21 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | N-glycosylation of PD-1 promotes binding of camrelizumab.
Embo Rep., 21, 2020
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7CUT
 | | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with Z-VAD-FMK | | 分子名称: | 3C protein, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Lu, M, Yang, H.T, Wang, Z.Y, Zhao, Y, Xing, Y.F. | | 登録日 | 2020-08-24 | | 公開日 | 2021-06-23 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | | 主引用文献 | Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M pro .
Signal Transduct Target Ther, 6, 2021
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7CUU
 | | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with MG132 | | 分子名称: | 3C protein, DIMETHYL SULFOXIDE, GLYCEROL, ... | | 著者 | Lu, M, Yang, H.T, Wang, Z.Y, Zhao, Y, Xing, Y.F. | | 登録日 | 2020-08-24 | | 公開日 | 2021-06-23 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | | 主引用文献 | Identification of proteasome and caspase inhibitors targeting SARS-CoV-2 M pro .
Signal Transduct Target Ther, 6, 2021
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7YG4
 | | Structure of WTAP-VIRMA in the m6A writer complex | | 分子名称: | Pre-mRNA-splicing regulator WTAP, Protein virilizer homolog | | 著者 | Yan, X.H, Guan, Z.Y, Tang, C, Yin, P. | | 登録日 | 2022-07-11 | | 公開日 | 2022-11-23 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | AI-empowered integrative structural characterization of m 6 A methyltransferase complex.
Cell Res., 32, 2022
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3J4T
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7V61
 | | ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3E8, ... | | 著者 | Yan, R.H, Zhang, Y.Y, Li, Y.N, Zhou, Q. | | 登録日 | 2021-08-18 | | 公開日 | 2022-06-22 | | 最終更新日 | 2024-11-13 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | ACE2-targeting monoclonal antibody as potent and broad-spectrum coronavirus blocker.
Signal Transduct Target Ther, 6, 2021
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6J99
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7D5I
 | | Structure of Mycobacterium smegmatis bd complex in the apo-form. | | 分子名称: | CIS-HEME D HYDROXYCHLORIN GAMMA-SPIROLACTONE, Cytochrome D ubiquinol oxidase subunit 1, HEME B/C, ... | | 著者 | Wang, W, Gong, H, Gao, Y, Zhou, X, Rao, Z. | | 登録日 | 2020-09-26 | | 公開日 | 2021-06-23 | | 最終更新日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.79 Å) | | 主引用文献 | Cryo-EM structure of mycobacterial cytochrome bd reveals two oxygen access channels.
Nat Commun, 12, 2021
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5ZUV
 | | Crystal Structure of the Human Coronavirus 229E HR1 motif in complex with pan-CoVs inhibitor EK1 | | 分子名称: | CHLORIDE ION, Spike glycoprotein,Spike glycoprotein,inhibitor EK1 | | 著者 | Yan, L, Yang, B, Wilson, I.A. | | 登録日 | 2018-05-08 | | 公開日 | 2019-04-10 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | | 主引用文献 | A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike.
Sci Adv, 5, 2019
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6JHO
 | | The complex crystal structure of Cagbeta with CagZ revealed a novel regulatory mechanism for T4SS coupling ATPase in Helicobacter pylori | | 分子名称: | Cag pathogenicity island protein (Cag5), Cag pathogenicity island protein (Cag6) | | 著者 | Wu, X, Zhao, Y, Sun, L, Ye, X, Jiang, M, Wang, Q, Wang, Q, Wu, Y. | | 登録日 | 2019-02-18 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The complex crystal structure of Cagbeta with CagZ revealed a novel regulatory mechanism in VirD4 coupling ATPase
To Be Published
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5ZVM
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5ZVK
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6A3V
 | | Complex structure of human 4-1BB and 4-1BBL | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 9, Tumor necrosis factor receptor superfamily member 9 | | 著者 | Li, Y, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | | 登録日 | 2018-06-17 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.391 Å) | | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
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6A3W
 | | Complex structure of 4-1BB and utomilumab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor receptor superfamily member 9, utomilumab VH, ... | | 著者 | Li, Y, Tan, S, Zhang, C, Chai, Y, Qi, J, Tien, P, Gao, S, Gao, G.F. | | 登録日 | 2018-06-17 | | 公開日 | 2018-10-10 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Limited Cross-Linking of 4-1BB by 4-1BB Ligand and the Agonist Monoclonal Antibody Utomilumab.
Cell Rep, 25, 2018
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