4MLT
 
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3RUQ
 | | Crystal structure of Cpn-WT in complex with ADP from Methanococcus maripaludis | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin, MAGNESIUM ION | | 著者 | Pereira, J.H, Ralston, C.Y, Douglas, N.R, Kumar, R, McAndrew, R.P, Knee, K.M, Frydman, J, Adams, P.D. | | 登録日 | 2011-05-05 | | 公開日 | 2012-01-04 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.798 Å) | | 主引用文献 | Mechanism of nucleotide sensing in group II chaperonins.
Embo J., 31, 2012
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3S20
 | | Crystal structure of cerulenin bound Xanthomonas campestri OleA (soak) | | 分子名称: | (2S, 3R)-3-HYDROXY-4-OXO-7,10-TRANS,TRANS-DODECADIENAMIDE, 3-oxoacyl-[ACP] synthase III, ... | | 著者 | Goblirsch, B.R, Wilmot, C.M. | | 登録日 | 2011-05-16 | | 公開日 | 2012-05-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8796 Å) | | 主引用文献 | Crystal Structures of Xanthomonas campestris OleA Reveal Features That Promote Head-to-Head Condensation of Two Long-Chain Fatty Acids.
Biochemistry, 51, 2012
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3UHM
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3UIE
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4OP5
 | | Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, Extended spectrum beta-lactamase TEM-63, ... | | 著者 | Dellus-Gur, E, Elias, M, Fraser, J.S, Tawfik, D.S. | | 登録日 | 2014-02-05 | | 公開日 | 2015-05-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | | 主引用文献 | Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.
J. Mol. Biol., 427, 2015
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4OQH
 | | Crystal structure of stabilized TEM-1 beta-lactamase variant v.13 carrying R164S mutation in complex with boron-based inhibitor EC25 | | 分子名称: | 1,2-ETHANEDIOL, 3-[(2R)-2-{[(2R)-2-amino-2-phenylacetyl]amino}-2-(dihydroxyboranyl)ethyl]benzoic acid, CALCIUM ION, ... | | 著者 | Dellus-Gur, E, Elias, M, Fraser, J.S, Tawfik, D.S. | | 登録日 | 2014-02-09 | | 公開日 | 2015-05-20 | | 最終更新日 | 2018-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Negative Epistasis and Evolvability in TEM-1 beta-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.
J. Mol. Biol., 427, 2015
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4O93
 | | Crystal structure of Thermus thermophilis transhydrogeanse domain II dimer | | 分子名称: | MERCURY (II) ION, NAD(P) transhydrogenase subunit alpha 2, NAD(P) transhydrogenase subunit beta | | 著者 | Leung, J.H, Yamaguchi, M, Moeller, A, Schurig-Briccio, L.A, Gennis, R.B, Potter, C.S, Carragher, B, Stout, C.D. | | 登録日 | 2013-12-31 | | 公開日 | 2014-12-31 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | Structural biology. Division of labor in transhydrogenase by alternating proton translocation and hydride transfer.
Science, 347, 2015
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4ONQ
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4OOM
 | | Crystal structure of PBP3 in complex with BAL30072 ((2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methoxy]imino}-N-{(2S)-1-hydroxy-3-methyl-3-[(sulfooxy)amino]butan-2-yl}ethanamide) | | 分子名称: | (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(1,5-dihydroxy-4-oxo-1,4-dihydropyridin-2-yl)methoxy]imino}-N-{(2S)-1-hydroxy-3-methyl-3-[(sulfooxy)amino]butan-2-yl}ethanamide, Cell division protein FtsI [Peptidoglycan synthetase] | | 著者 | Han, S, Caspers, N, Knafels, J.D. | | 登録日 | 2014-02-03 | | 公開日 | 2014-05-07 | | 最終更新日 | 2014-05-21 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria.
J.Med.Chem., 57, 2014
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4ONO
 | | CD1c in complex with PM (phosphomycoketide) | | 分子名称: | (4R,8S,16S,20R)-4,8,12,16,20-pentamethylheptacosyl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin/T-cell surface glycoprotein CD1c/T-cell surface glycoprotein CD1b chimeric protein, ... | | 著者 | Roy, S, Adams, E.J. | | 登録日 | 2014-01-28 | | 公開日 | 2014-10-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | | 主引用文献 | Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alpha beta T cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3TCT
 | | Structure of wild-type TTR in complex with tafamidis | | 分子名称: | 2-(3,5-dichlorophenyl)-1,3-benzoxazole-6-carboxylic acid, Transthyretin | | 著者 | Connelly, S, Kelly, J.W, Wilson, I.A. | | 登録日 | 2011-08-09 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade.
Proc.Natl.Acad.Sci.USA, 109, 2012
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3QRN
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4OV8
 | | Crystal Structure of the TMH1-lock mutant of the mature form of pleurotolysin B | | 分子名称: | CHLORIDE ION, GLYCEROL, Pleurotolysin B, ... | | 著者 | Kondos, S.C, Law, R.H.P, Whisstock, J.C, Dunstone, M.A. | | 登録日 | 2014-02-20 | | 公開日 | 2015-02-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin
Plos Biol., 13, 2015
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3QQ1
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3QXE
 | | Crystal Structure of Co-type Nitrile Hydratase from Pseudomonas putida. | | 分子名称: | COBALT (III) ION, Co-type Nitrile Hydratase alpha subunit, Co-type Nitrile Hydratase beta subunit, ... | | 著者 | Brodkin, H.R, Novak, W.R.P, Ringe, D, Petsko, G.A. | | 登録日 | 2011-03-01 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.104 Å) | | 主引用文献 | Evidence of the Participation of Remote Residues in the Catalytic Activity of Co-Type Nitrile Hydratase from Pseudomonas putida.
Biochemistry, 50, 2011
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4O6W
 | | Peptide-Based Inhibitors of Plk1 Polo-box Domain | | 分子名称: | Peptide-Based inhibitor, Serine/threonine-protein kinase PLK1 | | 著者 | Qian, W.-J, Park, J.-E, Lim, D.C, Park, S.-Y, Lee, K.-W, Yaffe, M.B, Lee, K.S, Burke, T.R. | | 登録日 | 2013-12-23 | | 公開日 | 2014-12-03 | | 実験手法 | X-RAY DIFFRACTION (1.448 Å) | | 主引用文献 | Mono-anionic phosphopeptides produced by unexpected histidine alkylation exhibit high plk1 polo-box domain-binding affinities and enhanced antiproliferative effects in hela cells.
Biopolymers, 102, 2014
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3QYH
 | | Crystal Structure of Co-type Nitrile Hydratase beta-H71L from Pseudomonas putida. | | 分子名称: | COBALT (III) ION, Co-type Nitrile Hydratase alpha subunit, Co-type Nitrile Hydratase beta subunit | | 著者 | Brodkin, H.R, Novak, W.R.P, Ringe, D, Petsko, G.A. | | 登録日 | 2011-03-03 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Evidence of the Participation of Remote Residues in the Catalytic Activity of Co-Type Nitrile Hydratase from Pseudomonas putida.
Biochemistry, 50, 2011
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4OLD
 | | Crystal structure of AmpC beta-lactamase in complex with the product form of (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | | 分子名称: | (2R)-2-[(R)-amino(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | | 著者 | Shoichet, B.K, Barelier, S. | | 登録日 | 2014-01-23 | | 公開日 | 2014-05-28 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | Substrate deconstruction and the nonadditivity of enzyme recognition.
J.Am.Chem.Soc., 136, 2014
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4O9T
 | | Mechanism of transhydrogenase coupling proton translocation and hydride transfer | | 分子名称: | NAD(P) transhydrogenase subunit alpha 2, NAD(P) transhydrogenase subunit beta | | 著者 | Leung, J.H, Yamaguchi, M, Moeller, A, Schurig-Briccio, L.A, Gennis, R.B, Potter, C.S, Carragher, B, Stout, C.D. | | 登録日 | 2014-01-02 | | 公開日 | 2014-06-11 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.079 Å) | | 主引用文献 | Structural biology. Division of labor in transhydrogenase by alternating proton translocation and hydride transfer.
Science, 347, 2015
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4OEB
 | | Structure of membrane binding protein pleurotolysin A from Pleurotus ostreatus | | 分子名称: | Pleurotolysin A, SULFATE ION | | 著者 | Dunstone, M.A, Caradoc-Davies, T.T, Whisstock, J.C, Law, R.H.P. | | 登録日 | 2014-01-12 | | 公開日 | 2015-02-18 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Conformational Changes during Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
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4OGY
 | | Crystal structure of Fab DX-2930 in complex with human plasma kallikrein at 2.1 Angstrom resolution | | 分子名称: | 1,2-ETHANEDIOL, DX-2930 HEAVY CHAIN, DX-2930 LIGHT CHAIN, ... | | 著者 | Edwards, T.E, Clifton, M.C, Abendroth, J, Nixon, A, Ladner, R. | | 登録日 | 2014-01-16 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Inhibition of plasma kallikrein by a highly specific active site blocking antibody.
J.Biol.Chem., 289, 2014
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4ONH
 | | Crystal Structure of DN6 TCR | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GLYCEROL, ... | | 著者 | Roy, S, Adams, E.J. | | 登録日 | 2014-01-28 | | 公開日 | 2014-10-08 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.008 Å) | | 主引用文献 | Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alpha beta T cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3TFQ
 | | Crystal structure of 11b-hsd1 double mutant (l262r, f278e) complexed with 8-{[(2-CYANOPYRIDIN-3-YL)METHYL]SULFANYL}-6-HYDROXY-3,4-DIHYDRO-1H-PYRANO[3,4-C]PYRIDINE-5-CARBONITRILE | | 分子名称: | 8-{[(2-cyanopyridin-3-yl)methyl]sulfanyl}-6-hydroxy-3,4-dihydro-1H-pyrano[3,4-c]pyridine-5-carbonitrile, Corticosteroid 11-beta-dehydrogenase isozyme 1, GLYCEROL, ... | | 著者 | Sheriff, S. | | 登録日 | 2011-08-16 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11beta-hydroxydehydrogenase 1 (11beta-HSD1)
Bioorg.Med.Chem.Lett., 21, 2011
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3SXD
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