4V9L
| 70S Ribosome translocation intermediate FA-3.6A containing elongation factor EFG/FUSIDIC ACID/GDP, mRNA, and tRNA bound in the pe*/E state. | 分子名称: | 23S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Zhou, J, Lancaster, L, Donohue, J.P, Noller, H.F. | 登録日 | 2013-04-24 | 公開日 | 2014-07-09 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Crystal structures of EF-G-ribosome complexes trapped in intermediate states of translocation. Science, 340, 2013
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7T4A
| Structure of SARS-CoV-2 3CL protease in complex with inhibitor 11c | 分子名称: | (1R,2S)-2-[(N-{[(7-cyano-7-azaspiro[3.5]nonan-2-yl)oxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-[(N-{[(7-cyano-7-azaspiro[3.5]nonan-2-yl)oxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ... | 著者 | Lovell, S, Liu, L, Battaile, K.P, Chamandi, S.D, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2021-12-09 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease. J.Med.Chem., 65, 2022
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7T3Z
| Structure of MERS 3CL protease in complex with inhibitor 9c | 分子名称: | (1R,2S)-2-{[N-({[(2r,4R)-7-acetyl-7-azaspiro[3.5]non-5-en-2-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-{[N-({[7-(phenylacetyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}propane-1-sulfonic acid, 3C-like proteinase | 著者 | Lovell, S, Liu, L, Battaile, K.P, Chamandi, S.D, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2021-12-09 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease. J.Med.Chem., 65, 2022
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7T85
| Crystal Structure of the N-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli | 分子名称: | 1,2-ETHANEDIOL, ACETIC ACID, Phosphate acetyltransferase, ... | 著者 | Kim, Y, Dementiev, A, Welk, L, Endres, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-12-15 | 公開日 | 2021-12-29 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the N-terminal Domain of the Phosphate Acetyltransferase from Escherichia coli To Be Published
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3DKM
| Crystal structure of the HECTD1 CPH domain | 分子名称: | E3 ubiquitin-protein ligase HECTD1 | 著者 | Walker, J.R, Qiu, L, Li, Y, Bountra, C, Wolkstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2008-06-25 | 公開日 | 2008-08-19 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Crystal structure of the CPH domain of the E3 ubiquitin-protein ligase HECTD1. To be Published
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7T48
| Structure of SARS-CoV-2 3CL protease in complex with inhibitor 9c | 分子名称: | (1R,2S)-2-{[N-({[(2r,4R)-7-acetyl-7-azaspiro[3.5]non-5-en-2-yl]oxy}carbonyl)-L-leucyl]amino}-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]-2-{[N-({[7-(phenylacetyl)-7-azaspiro[3.5]nonan-2-yl]oxy}carbonyl)-L-leucyl]amino}propane-1-sulfonic acid, 3C-like proteinase, ... | 著者 | Lovell, S, Liu, L, Battaile, K.P, Chamandi, S.D, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2021-12-09 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease. J.Med.Chem., 65, 2022
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3DAX
| Crystal structure of human CYP7A1 | 分子名称: | Cytochrome P450 7A1, PROTOPORPHYRIN IX CONTAINING FE, UNKNOWN ATOM OR ION | 著者 | Strushkevich, N.V, Tempel, W, Dombrovski, L, Dong, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Wilkstrom, M, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | 登録日 | 2008-05-30 | 公開日 | 2008-08-05 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Crystal structure of human CYP7A1 To be Published
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7T44
| Structure of SARS-CoV-2 3CL protease in complex with inhibitor 4c | 分子名称: | (1R,2S)-2-[(N-{[(2-azaspiro[3.3]heptan-6-yl)oxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-1-hydroxy-2-{[N-({[2-(methanesulfonyl)-2-azaspiro[3.3]heptan-6-yl]oxy}carbonyl)-L-leucyl]amino}-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ... | 著者 | Liu, L, Lovell, S, Battaile, K.P, Chamandi, S.D, Kim, Y, Groutas, W.C, Chang, K.O. | 登録日 | 2021-12-09 | 公開日 | 2021-12-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structure-Guided Design of Potent Spirocyclic Inhibitors of Severe Acute Respiratory Syndrome Coronavirus-2 3C-like Protease. J.Med.Chem., 65, 2022
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3DME
| Crystal structure of conserved exported protein from Bordetella pertussis. NorthEast Structural Genomics target BeR141 | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, L(+)-TARTARIC ACID, conserved exported protein | 著者 | Seetharaman, J, Abashidze, M, Wang, D, Janjua, H, Foote, E.L, Xiao, R, Liu, J, Everett, J.K, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2008-06-30 | 公開日 | 2008-08-26 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Crystal structure of conserved exported protein from Bordetella pertussis. NorthEast Structural Genomics target BeR141 To be Published
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3DMV
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3DC9
| Use of Carbonic Anhydrase II, IX Active-Site Mimic, for the Purpose of Screening Inhibitors for Possible Anti-Cancer Properties | 分子名称: | Carbonic anhydrase 2, ZINC ION | 著者 | Genis, C, Sippel, K.H, Case, N, Govindasamy, L, Agbandje-Mckenna, M, Mckenna, R. | 登録日 | 2008-06-03 | 公開日 | 2009-03-03 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties Biochemistry, 48, 2009
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3DN2
| Bromopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant | 分子名称: | 1-bromo-2,3,4,5,6-pentafluorobenzene, 2-HYDROXYETHYL DISULFIDE, Lysozyme, ... | 著者 | Liu, L, Matthews, B.W. | 登録日 | 2008-07-01 | 公開日 | 2008-11-11 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. J.Mol.Biol., 385, 2009
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4W5M
| Prp peptide | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, PrP peptide | 著者 | Yu, L, Lee, S.-J, Yee, V. | 登録日 | 2014-08-18 | 公開日 | 2015-05-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations. Biochemistry, 54, 2015
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4W5Y
| Crystal structure of Prp pepttide | 分子名称: | Prp peptide | 著者 | Yu, L, Lee, S.-J, Yee, V. | 登録日 | 2014-08-19 | 公開日 | 2015-05-27 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.122 Å) | 主引用文献 | Crystal Structures of Polymorphic Prion Protein beta 1 Peptides Reveal Variable Steric Zipper Conformations. Biochemistry, 54, 2015
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3DDX
| HK97 bacteriophage capsid Expansion Intermediate-II model | 分子名称: | Major capsid protein | 著者 | Lee, K.K, Gan, L, Conway, J.F, Hendrix, R.W, Steven, A.C, Johnson, J.E. | 登録日 | 2008-06-06 | 公開日 | 2008-11-04 | 最終更新日 | 2024-02-21 | 実験手法 | ELECTRON MICROSCOPY | 主引用文献 | Virus capsid expansion driven by the capture of mobile surface loops. Structure, 16, 2008
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4UFZ
| Synthesis of Novel NAD Dependant DNA Ligase Inhibitors via Negishi Cross-Coupling: Development of SAR and Resistance Studies | 分子名称: | 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 5,7-bis(azanyl)-2-tert-butyl-4-(1,3-thiazol-2-yl)pyrido[2,3-d]pyrimidine-6-carbonitrile, DNA LIGASE | 著者 | Murphy-Benenato, K.E, Boriack-Sjodin, P.A, Martinez-Botella, G, Carcanague, D, Gingipali, L, Gowravaram, M, Harang, J, Hale, M, Ioannidis, G, Jahic, H, Johnstone, M, Kutschke, A, Laganas, V.A, Loch, J, Oguto, H, Patel, S.J. | 登録日 | 2015-03-20 | 公開日 | 2015-10-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Negishi Cross-Coupling Enabled Synthesis of Novel Nad(+)-Dependent DNA Ligase Inhibitors and Sar Development. Bioorg.Med.Chem.Lett., 25, 2015
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4WFS
| Crystal Structure of tRNA-dihydrouridine(20) synthase catalytic domain | 分子名称: | CHLORIDE ION, FLAVIN MONONUCLEOTIDE, SULFATE ION, ... | 著者 | Bou-Nader, C, Pecqueur, L, Kamah, A, Bregeon, D, Golinelli-Pimpaneau, B, Guimaraes, B.G, Fontecave, M, Hamdane, D. | 登録日 | 2014-09-17 | 公開日 | 2015-10-07 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | An extended dsRBD is required for post-transcriptional modification in human tRNAs. Nucleic Acids Res., 43, 2015
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7SU3
| CryoEM structure of DNA-PK complex VII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3'), ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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4WGI
| A Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1) | 分子名称: | (2S)-2-[(2S,3R)-10-{[(4-fluorophenyl)sulfonyl]amino}-3-methyl-2-[(methyl{[4-(trifluoromethyl)phenyl]carbamoyl}amino)methyl]-6-oxo-3,4-dihydro-2H-1,5-benzoxazocin-5(6H)-yl]propanoic acid, FORMIC ACID, MAGNESIUM ION, ... | 著者 | Clifton, M.C, Fairman, J.W, Fang, C, D'Souza, B, Fulroth, B, Leed, A, McCarren, P, Wang, L, Wang, Y, Kaushik, V, Palmer, M, Wei, G, Golub, T.R, Hubbard, B.K, Serrano-Wu, M.H. | 登録日 | 2014-09-18 | 公開日 | 2014-11-19 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1). Acs Med.Chem.Lett., 5, 2014
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3DN8
| Iodopentafluorobenzene binding in the hydrophobic cavity of T4 lysozyme L99A mutant (seleno version) | 分子名称: | 1,2,3,4,5-pentafluoro-6-iodobenzene, 2-HYDROXYETHYL DISULFIDE, BETA-MERCAPTOETHANOL, ... | 著者 | Liu, L, Matthews, B.W. | 登録日 | 2008-07-01 | 公開日 | 2008-11-11 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Halogenated benzenes bound within a non-polar cavity in T4 lysozyme provide examples of I...S and I...Se halogen-bonding. J.Mol.Biol., 385, 2009
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7SUD
| CryoEM structure of DNA-PK complex VIII | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, DNA-dependent protein kinase catalytic subunit, MAGNESIUM ION, ... | 著者 | Chen, X, Liu, L, Gellert, M, Yang, W. | 登録日 | 2021-11-16 | 公開日 | 2022-01-12 | 最終更新日 | 2022-01-19 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Autophosphorylation transforms DNA-PK from protecting to processing DNA ends. Mol.Cell, 82, 2022
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5ZS8
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4WIN
| Crystal structure of the GATase domain from Plasmodium falciparum GMP synthetase | 分子名称: | GMP synthetase, NITRATE ION | 著者 | Ballut, L, Violot, S, Haser, R, Aghajari, N. | 登録日 | 2014-09-26 | 公開日 | 2015-12-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation. Nat Commun, 6, 2015
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5ZWR
| Structural Basis for the Enantioselectivity of Est-Y29 toward (S)-ketoprofen | 分子名称: | (2S)-2-[3-(benzenecarbonyl)phenyl]propanoic acid, Est-Y29, GLYCEROL | 著者 | Ngo, D.T, Oh, C, Park, K, Nguyen, L, Byun, H.M, Kim, S, Yoon, S, Ryu, Y, Ryu, B.H, Kim, T.D, Kim, K.K. | 登録日 | 2018-05-16 | 公開日 | 2019-03-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural Basis for the Enantioselectivity of Esterase Est-Y29 toward (S)-Ketoprofen Acs Catalysis, 9, 2019
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3DOA
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