8DTW
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![BU of 8dtw by Molmil](/molmil-images/mine/8dtw) | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023036 | 分子名称: | 5-hydroxy-N-[2-(2-methoxypyridin-4-yl)ethyl]-6-oxo-2-{[2-(trifluoromethyl)phenyl]methyl}-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MAGNESIUM ION, ... | 著者 | Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. | 登録日 | 2022-07-26 | 公開日 | 2022-09-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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8E4S
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![BU of 8e4s by Molmil](/molmil-images/mine/8e4s) | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ001023034 | 分子名称: | 5-hydroxy-6-oxo-N-[2-(pyridin-4-yl)ethyl]-2-{[2-(trifluoromethyl)phenyl]methyl}-3,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | 著者 | Cuypers, M.G, Slavish, J.P, Rankovic, Z, White, S.W. | 登録日 | 2022-08-18 | 公開日 | 2022-09-21 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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8EDZ
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![BU of 8edz by Molmil](/molmil-images/mine/8edz) | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319 | 分子名称: | Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Cuypers, M.G, Slavish, J.P, Jayaraman, S, Rankovic, Z, White, S.W. | 登録日 | 2022-09-06 | 公開日 | 2022-10-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | The crystal structure of I38T mutant PA endonuclease (2009/H1N1/CALIFORNIA) in complex with compound SJ000986319 To Be Published
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7UQ1
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![BU of 7uq1 by Molmil](/molmil-images/mine/7uq1) | The X-ray crystal structure of the N-terminal domain of Staphylococcus aureus Fatty Acid Kinase A (FakA, residues 1-208) in complex with AMP and a single Mg ion at the dinuclear binding site | 分子名称: | ADENOSINE MONOPHOSPHATE, Fatty Acid Kinase A, GLYCEROL, ... | 著者 | Cuypers, M.G, Subramanian, C, Seetharaman, J, Rock, C.O, White, S.W. | 登録日 | 2022-04-18 | 公開日 | 2022-05-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Domain architecture and catalysis of the Staphylococcus aureus fatty acid kinase. J.Biol.Chem., 298, 2022
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7SG3
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![BU of 7sg3 by Molmil](/molmil-images/mine/7sg3) | The X-ray crystal structure of the Staphylococcus aureus Fatty Acid Kinase B1 mutant A121I-A158L to 2.35 Angstrom resolution (Open form chain A, Palmitate bound) | 分子名称: | Fatty Acid Kinase B1, PALMITIC ACID | 著者 | Cuypers, M.G, Gullett, J.M, Rock, C.O, White, S.W. | 登録日 | 2021-10-04 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes. J.Biol.Chem., 298, 2022
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7SCL
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![BU of 7scl by Molmil](/molmil-images/mine/7scl) | The X-ray crystal structure of Staphylococcus aureus Fatty Acid Kinase B1 (FakB1) mutant R173A in complex with Palmitate to 1.60 Angstrom resolution | 分子名称: | Fatty Acid Kinase B1, GLYCEROL, PALMITIC ACID | 著者 | Cuypers, M.G, Gullett, J.M, Subramanian, C, Rock, C.O, White, S.W. | 登録日 | 2021-09-28 | 公開日 | 2021-10-27 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Identification of structural transitions in bacterial fatty acid binding proteins that permit ligand entry and exit at membranes. J.Biol.Chem., 298, 2022
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7RM7
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![BU of 7rm7 by Molmil](/molmil-images/mine/7rm7) | The X-ray crystal structure of the N-terminal domain of Staphylococcus aureus Fatty Acid Kinase A (FakA, residues 1-208) in complex with ADP to 1.025 Angstrom resolution | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Fatty Acid Kinase A, GLYCEROL, ... | 著者 | Cuypers, M.G, Subramanian, C, Rock, C.O, White, S.W. | 登録日 | 2021-07-26 | 公開日 | 2022-03-02 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (1.025 Å) | 主引用文献 | The X-ray crystal structure of the N-terminal domain of Staphylococcus aureus Fatty Acid Kinase A (FakA, residues 1-208) in complex with ADP to 1.025 Angstrom resolution To Be Published
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5CCY
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![BU of 5ccy by Molmil](/molmil-images/mine/5ccy) | 2009 H1N1 PA endonuclease in complex with dTMP | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein, THYMIDINE-5'-PHOSPHATE | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-07-02 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5CL0
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![BU of 5cl0 by Molmil](/molmil-images/mine/5cl0) | 2009 H1N1 PA endonuclease in complex with rUMP | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein, URIDINE-5'-MONOPHOSPHATE | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-07-15 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5CGV
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![BU of 5cgv by Molmil](/molmil-images/mine/5cgv) | 2009 H1N1 PA endonuclease in complex with L-742,001 | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, GLYCEROL, MANGANESE (II) ION, ... | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-07-09 | 公開日 | 2016-03-23 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
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5D9J
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![BU of 5d9j by Molmil](/molmil-images/mine/5d9j) | 2009 H1N1 PA endonuclease mutant F105S in complex with L-742,001 | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, Polymerase acidic protein | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-08-18 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5D4G
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![BU of 5d4g by Molmil](/molmil-images/mine/5d4g) | |
5D8U
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![BU of 5d8u by Molmil](/molmil-images/mine/5d8u) | 2009 H1N1 PA endonuclease mutant E119D in complex with L-742,001 | 分子名称: | (2Z)-4-[1-benzyl-4-(4-chlorobenzyl)piperidin-4-yl]-2-hydroxy-4-oxobut-2-enoic acid, MANGANESE (II) ION, Polymerase acidic protein | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-08-18 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5D42
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![BU of 5d42 by Molmil](/molmil-images/mine/5d42) | |
5DEB
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![BU of 5deb by Molmil](/molmil-images/mine/5deb) | |
5CZN
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![BU of 5czn by Molmil](/molmil-images/mine/5czn) | 2009 H1N1 PA endonuclease mutant E119D | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-07-31 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5DBS
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![BU of 5dbs by Molmil](/molmil-images/mine/5dbs) | |
5DES
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![BU of 5des by Molmil](/molmil-images/mine/5des) | 2009 H1N1 PA endonuclease domain | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-08-25 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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5D2O
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![BU of 5d2o by Molmil](/molmil-images/mine/5d2o) | 2009 H1N1 PA endonuclease mutant F105S | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein | 著者 | Kumar, G, White, S.W. | 登録日 | 2015-08-05 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Proc.Natl.Acad.Sci.USA, 113, 2016
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6V53
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![BU of 6v53 by Molmil](/molmil-images/mine/6v53) | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 | 分子名称: | Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein, ... | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | 登録日 | 2019-12-03 | 公開日 | 2020-12-09 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 To Be Published
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6V56
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![BU of 6v56 by Molmil](/molmil-images/mine/6v56) | The crystal structure of the 2009 H1N1 PA endonuclease wild type in complex with SJ000985494 | 分子名称: | Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, Polymerase acidic protein,Polymerase acidic protein, ... | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | 登録日 | 2019-12-03 | 公開日 | 2021-02-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000985494 To Be Published
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6VLL
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![BU of 6vll by Molmil](/molmil-images/mine/6vll) | The crystal structure of the 2009/H1N1/California PA endonuclease mutant I38T in complex with SJ000986213 | 分子名称: | MANGANESE (II) ION, Polymerase acidic protein, SULFATE ION, ... | 著者 | Cuypers, M.G, Slavish, P.J, Rankovic, Z, White, S.W. | 登録日 | 2020-01-24 | 公開日 | 2021-02-24 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.87 Å) | 主引用文献 | The crystal structure of the 2009 H1N1 PA endonuclease mutant I38T in complex with SJ000986213 To Be Published
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5JLT
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![BU of 5jlt by Molmil](/molmil-images/mine/5jlt) | The crystal structure of the bacteriophage T4 MotA C-terminal domain in complex with dsDNA reveals a novel protein-DNA recognition motif | 分子名称: | DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*TP*GP*CP*TP*TP*AP*AP*TP*AP*AP*TP*CP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*GP*AP*TP*TP*AP*TP*TP*AP*AP*GP*CP*AP*AP*AP*GP*CP*TP*TP*C)-3'), Middle transcription regulatory protein motA | 著者 | Cuypers, M.G, Robertson, R.M, Knipling, L, Hinton, D.M, White, S.W. | 登録日 | 2016-04-27 | 公開日 | 2017-05-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.955 Å) | 主引用文献 | The phage T4 MotA transcription factor contains a novel DNA binding motif that specifically recognizes modified DNA. Nucleic Acids Res., 46, 2018
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5JQ9
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![BU of 5jq9 by Molmil](/molmil-images/mine/5jq9) | Yersinia pestis DHPS with pterine-sulfa conjugate Compound 16 | 分子名称: | 1,2-ETHANEDIOL, 4-{[(2-amino-4-oxo-3,4-dihydropteridin-6-yl)methyl]amino}-N-(3,4-dimethyl-1,2-oxazol-5-yl)benzene-1-sulfonamide, Dihydropteroate synthase | 著者 | Wu, Y, White, S.W. | 登録日 | 2016-05-04 | 公開日 | 2016-08-10 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.101 Å) | 主引用文献 | Pterin-sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents. Bioorg.Med.Chem.Lett., 26, 2016
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7LM4
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![BU of 7lm4 by Molmil](/molmil-images/mine/7lm4) | The crystal structure of the I38T mutant PA Endonuclease (2009/H1N1/CALIFORNIA) in complex with SJ000988503 | 分子名称: | 5-hydroxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]-2-(2-methylphenyl)-6-oxo-1,6-dihydropyrimidine-4-carboxamide, Hexa Vinylpyrrolidone K15, MANGANESE (II) ION, ... | 著者 | Cuypers, M.G, Slavish, P.J, Jayaraman, S, Rankovic, Z, White, S.W. | 登録日 | 2021-02-05 | 公開日 | 2022-02-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Chemical scaffold recycling: Structure-guided conversion of an HIV integrase inhibitor into a potent influenza virus RNA-dependent RNA polymerase inhibitor designed to minimize resistance potential. Eur.J.Med.Chem., 247, 2023
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