5U4R
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![BU of 5u4r by Molmil](/molmil-images/mine/5u4r) | Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 53-1A09 Fab. | 分子名称: | VRC 315 53-1A09 Fab Heavy chain, VRC 315 53-1A09 Fab Light chain | 著者 | Joyce, M.G, Andrews, S.F, Mascola, J.R, McDermott, A.B, Kwong, P.D. | 登録日 | 2016-12-05 | 公開日 | 2017-11-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.762 Å) | 主引用文献 | Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans. Sci Immunol, 2, 2017
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5TR8
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![BU of 5tr8 by Molmil](/molmil-images/mine/5tr8) | Crystal structure of vaccine-elicited pan- influenza H1N1 neutralizing murine antibody 441D6. | 分子名称: | 441D6 Fab Heavy chain, 441D6 Fab Light chain, NICKEL (II) ION | 著者 | Joyce, M.G, Kanekiyo, M, Mascola, J.R, Graham, B.S, Kwong, P.D. | 登録日 | 2016-10-25 | 公開日 | 2018-05-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses. Nat.Immunol., 20, 2019
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7U0D
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6ILQ
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![BU of 6ilq by Molmil](/molmil-images/mine/6ilq) | Crystal structure of PPARgamma with compound BR101549 | 分子名称: | Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma, ethyl [2-butyl-6-oxo-1-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)[1,1'-biphenyl]-4-yl]methyl}-4-(propan-2-yl)-1,6-dihydropyrimidin-5-yl]acetate | 著者 | Hong, E, Jang, T.H, Chin, J, Kim, K.H, Jung, W, Kim, S.H. | 登録日 | 2018-10-19 | 公開日 | 2019-09-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.408 Å) | 主引用文献 | Identification of BR101549 as a lead candidate of non-TZD PPAR gamma agonist for the treatment of type 2 diabetes: Proof-of-concept evaluation and SAR. Bioorg.Med.Chem.Lett., 29, 2019
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7LRT
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![BU of 7lrt by Molmil](/molmil-images/mine/7lrt) | |
7LRS
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![BU of 7lrs by Molmil](/molmil-images/mine/7lrs) | |
7MM0
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![BU of 7mm0 by Molmil](/molmil-images/mine/7mm0) | Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, B1-182.1 Fab heavy chain, ... | 著者 | Zhou, T, Tsybovsky, T, Kwong, P.D. | 登録日 | 2021-04-29 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.15 Å) | 主引用文献 | Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Science, 373, 2021
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7MLZ
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![BU of 7mlz by Molmil](/molmil-images/mine/7mlz) | Cryo-EM structure of SARS-CoV-2 spike in complex with neutralizing antibody B1-182.1 that targets the receptor-binding domain | 分子名称: | B1-182.1 Fab heavy chain, B1-182.1 Fab light chain, Spike protein S1, ... | 著者 | Zhou, T, Tsybovsky, T, Kwong, P.D. | 登録日 | 2021-04-29 | 公開日 | 2021-07-28 | 最終更新日 | 2021-08-25 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants. Science, 373, 2021
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4NLD
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![BU of 4nld by Molmil](/molmil-images/mine/4nld) | Crystal structure of the hepatitis C virus NS5B RNA-dependent RNA polymerase complex with BMS-791325 also known as (1aR,12bS)-8-cyclohexyl-n-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide and 2-(4-fluorophenyl)-n-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide | 分子名称: | (1aR,12bS)-8-cyclohexyl-N-(dimethylsulfamoyl)-11-methoxy-1a-{[(1R,5S)-3-methyl-3,8-diazabicyclo[3.2.1]oct-8-yl]carbonyl}-1,1a,2,12b-tetrahydrocyclopropa[d]indolo[2,1-a][2]benzazepine-5-carboxamide, 2-(4-fluorophenyl)-N-methyl-6-[(methylsulfonyl)amino]-5-(propan-2-yloxy)-1-benzofuran-3-carboxamide, RNA-directed RNA polymerase, ... | 著者 | Sheriff, S. | 登録日 | 2013-11-14 | 公開日 | 2014-03-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Discovery and Preclinical Characterization of the Cyclopropylindolobenzazepine BMS-791325, A Potent Allosteric Inhibitor of the Hepatitis C Virus NS5B Polymerase. J.Med.Chem., 57, 2014
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6R5Q
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![BU of 6r5q by Molmil](/molmil-images/mine/6r5q) | Structure of XBP1u-paused ribosome nascent chain complex (post-state) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2019-03-25 | 公開日 | 2019-07-10 | 最終更新日 | 2019-10-30 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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8I4O
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![BU of 8i4o by Molmil](/molmil-images/mine/8i4o) | Design of a split green fluorescent protein for sensing and tracking an beta-amyloid | 分子名称: | Beta-amyloid, Split Green flourescent protein | 著者 | Taegeun, Y, Jinsu, L, Jungmin, Y, Jungmin, C, Wondo, H, Song, J.J, Haksung, K. | 登録日 | 2023-01-20 | 公開日 | 2023-11-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Engineering of a Fluorescent Protein for a Sensing of an Intrinsically Disordered Protein through Transition in the Chromophore State. Jacs Au, 3, 2023
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6R6P
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![BU of 6r6p by Molmil](/molmil-images/mine/6r6p) | Structure of XBP1u-paused ribosome nascent chain complex (rotated state) | 分子名称: | 18S rRNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shanmuganathan, V, Cheng, J, Berninghausen, O, Beckmann, R. | 登録日 | 2019-03-27 | 公開日 | 2019-07-10 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural and mutational analysis of the ribosome-arresting human XBP1u. Elife, 8, 2019
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7TB4
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7XTP
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![BU of 7xtp by Molmil](/molmil-images/mine/7xtp) | eIF4E in Complex with a Disulphide-Free Autonomous VH Domain | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4ss, [[(2R,3S,4R,5R)-5-(6-AMINO-3-METHYL-4-OXO-5H-IMIDAZO[4,5-C]PYRIDIN-1-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHOXY-HYDROXY-PHOSPHORYL] PHOSPHONO HYDROGEN PHOSPHATE | 著者 | Brown, C.J, Frosi, Y, Jiang, S, Lin, Y.C. | 登録日 | 2022-05-17 | 公開日 | 2022-07-27 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.828 Å) | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. Nat Commun, 13, 2022
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4TOT
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7PU7
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![BU of 7pu7 by Molmil](/molmil-images/mine/7pu7) | DNA polymerase from M. tuberculosis | 分子名称: | DNA polymerase III subunit alpha, Template, ZINC ION, ... | 著者 | Borsellini, A, Lamers, M.H. | 登録日 | 2021-09-28 | 公開日 | 2022-02-23 | 最終更新日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis. Acs Infect Dis., 8, 2022
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7D8B
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![BU of 7d8b by Molmil](/molmil-images/mine/7d8b) | Engineering Disulphide-Free Autonomous Antibody VH Domains to modulate intracellular pathways | 分子名称: | Eukaryotic translation initiation factor 4E, VH-S4 | 著者 | Frosi, Y, Lin, Y.C, Jiang, S, Brown, C.J. | 登録日 | 2020-10-07 | 公開日 | 2021-08-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | 主引用文献 | Engineering an autonomous VH domain to modulate intracellular pathways and to interrogate the eIF4F complex. Nat Commun, 13, 2022
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6WIY
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![BU of 6wiy by Molmil](/molmil-images/mine/6wiy) | Crystal structure of Fab 54-1G05 | 分子名称: | Fab 54-1G05 heavy chain, Fab 54-1G05 light chain, GLYCEROL | 著者 | Wu, N.C, Wilson, I.A. | 登録日 | 2020-04-11 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor. Cell Host Microbe, 28, 2020
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6WIZ
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6WJ0
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![BU of 6wj0 by Molmil](/molmil-images/mine/6wj0) | Crystal structure of Fab 54-4H03 | 分子名称: | Fab 54-4H03 heavy chain, Fab 54-4H03 light chain, GLYCEROL | 著者 | Wu, N.C, Wilson, I.A. | 登録日 | 2020-04-11 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor. Cell Host Microbe, 28, 2020
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6WJ1
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![BU of 6wj1 by Molmil](/molmil-images/mine/6wj1) | Crystal structure of Fab 54-4H03 bound to H1 influenza hemagglutinin | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 54-4H03 heavy chain, ... | 著者 | Wu, N.C, Wilson, I.A. | 登録日 | 2020-04-11 | 公開日 | 2020-07-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.503 Å) | 主引用文献 | Convergent Evolution in Breadth of Two VH6-1-Encoded Influenza Antibody Clonotypes from a Single Donor. Cell Host Microbe, 28, 2020
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6VN2
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![BU of 6vn2 by Molmil](/molmil-images/mine/6vn2) | USP7 IN COMPLEX WITH LIGAND COMPOUND 18 | 分子名称: | 1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione, ACETATE ION, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M. | 登録日 | 2020-01-29 | 公開日 | 2020-04-29 | 最終更新日 | 2020-06-17 | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020
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6VN3
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![BU of 6vn3 by Molmil](/molmil-images/mine/6vn3) | USP7 IN COMPLEX WITH LIGAND COMPOUND 23 | 分子名称: | 1-{[7-(5-chloro-2-{[(3R,4S)-4-fluoropyrrolidin-3-yl]oxy}-3-methylphenyl)thieno[3,2-b]pyridin-2-yl]methyl}-1H-pyrrole-2,5-dione, Ubiquitin carboxyl-terminal hydrolase 7 | 著者 | Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M. | 登録日 | 2020-01-29 | 公開日 | 2020-04-29 | 最終更新日 | 2020-06-17 | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020
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6VN6
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![BU of 6vn6 by Molmil](/molmil-images/mine/6vn6) | USP7 IN COMPLEX WITH LIGAND COMPOUND 14 | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7, ZINC ION, [(2R)-5-chloro-7-{2-[(2S)-1-chloro-2,3-dihydroxypropan-2-yl]thieno[3,2-b]pyridin-7-yl}-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone | 著者 | Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M. | 登録日 | 2020-01-29 | 公開日 | 2020-04-29 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020
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6VN5
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![BU of 6vn5 by Molmil](/molmil-images/mine/6vn5) | USP7 IN COMPLEX WITH LIGAND COMPOUND 7 | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 7, [(2R)-7-(2-aminopyridin-4-yl)-5-chloro-2,3-dihydro-1-benzofuran-2-yl](piperazin-1-yl)methanone | 著者 | Leger, P.R, Wustrow, D.J, Hu, D.X, Krapp, S, Maskos, K, Blaesse, M. | 登録日 | 2020-01-29 | 公開日 | 2020-04-29 | 最終更新日 | 2020-06-10 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity. J.Med.Chem., 63, 2020
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