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5T6W
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BU of 5t6w by Molmil
HLA-B*57:01 presenting SSTRGISQLW
分子名称: Beta-2-microglobulin, Decapeptide: SER-SER-THR-ARG-GLY-ILE-SER-GLN-LEU-TRP, GLYCEROL, ...
著者Pymm, P, Rossjohn, J, Vivian, J.P.
登録日2016-09-01
公開日2017-03-01
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Nat. Struct. Mol. Biol., 24, 2017
5T6Z
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BU of 5t6z by Molmil
KIR3DL1 in complex with HLA-B*57:01-TW10
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, Decapeptide: THR-SER-THR-LEU-GLN-GLU-GLN-ILE-GLY-TRP, ...
著者Pymm, P, Rossjohn, J, Vivian, J.P.
登録日2016-09-02
公開日2017-03-01
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape.
Nat. Struct. Mol. Biol., 24, 2017
4G9D
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BU of 4g9d by Molmil
Crystal Structure of HLA B2705-KK10
分子名称: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
著者Gras, S, Wilmann, P.G, Rossjohn, J.
登録日2012-07-23
公開日2013-03-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献A Molecular Basis for the Control of Preimmune Escape Variants by HIV-Specific CD8(+) T Cells.
Immunity, 38, 2013
5JQ1
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BU of 5jq1 by Molmil
Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactosamine mimic
分子名称: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
著者Liu, S.
登録日2016-05-04
公開日2017-06-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
4JKW
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BU of 4jkw by Molmil
Structure of the extracellular domain of butyrophilin BTN3A1 in complex with Isopentenyl pyrophosphate (IPP)
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Butyrophilin subfamily 3 member A1
著者Kumar, A, Mori, L, De Libero, G.
登録日2013-03-12
公開日2013-07-24
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Butyrophilin 3A1 binds phosphorylated antigens and stimulates human gamma delta T cells.
Nat.Immunol., 14, 2013
5HHO
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BU of 5hho by Molmil
Crystal Structure of the JM22 TCR in complex with HLA-A*0201 in complex with M1-G4E
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Gras, S, Josephs, T.M, Rossjohn, J.
登録日2016-01-11
公開日2016-03-23
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.
Proc.Natl.Acad.Sci.USA, 113, 2016
4JRY
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BU of 4jry by Molmil
Crystal Structure of SB47 TCR-HLA B*3505-LPEP complex
分子名称: Beta-2-microglobulin, MAGNESIUM ION, MHC class I antigen, ...
著者Liu, Y.C, Rossjohn, J, Gras, S.
登録日2013-03-22
公開日2013-04-10
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.
J.Biol.Chem., 288, 2013
5JPV
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Efficient targeting of the asialoglycoprotein receptor by polyvalent display of a compact galactoseamine mimic
分子名称: Asialoglycoprotein receptor 1, CALCIUM ION, CHLORIDE ION, ...
著者Liu, S.
登録日2016-05-04
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Efficient Liver Targeting by Polyvalent Display of a Compact Ligand for the Asialoglycoprotein Receptor.
J. Am. Chem. Soc., 139, 2017
4JRX
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Crystal Structure of CA5 TCR-HLA B*3505-LPEP complex
分子名称: Beta-2-microglobulin, CA5 TCR alpha chain, CA5 TCR beta chain, ...
著者Liu, Y.C, Rossjohn, J, Gras, S.
登録日2013-03-22
公開日2013-04-10
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Highly divergent T-cell receptor binding modes underlie specific recognition of a bulged viral peptide bound to a human leukocyte antigen class I molecule.
J.Biol.Chem., 288, 2013
4I4W
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BU of 4i4w by Molmil
Peptide length determines the outcome of T cell receptor/peptide-MHCI engagement
分子名称: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
著者Rizkallah, P.J, Wooldridge, L, Cole, D.K.
登録日2012-11-28
公開日2013-01-02
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Peptide length determines the outcome of TCR/peptide-MHCI engagement.
Blood, 121, 2013
3UTQ
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BU of 3utq by Molmil
Human HLA-A*0201-ALWGPDPAAA
分子名称: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
著者Rizkallah, P.J, Cole, D.K, Sewell, A.K, Bulek, A.M.
登録日2011-11-26
公開日2012-01-25
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Nat.Immunol., 13, 2012
2MG9
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BU of 2mg9 by Molmil
Truncated EGF-A
分子名称: CALCIUM ION, Low-density lipoprotein receptor
著者Schroeder, C.I, Rosengren, K.
登録日2013-10-30
公開日2014-04-02
最終更新日2024-11-06
実験手法SOLUTION NMR
主引用文献Design and Synthesis of Truncated EGF-A Peptides that Restore LDL-R Recycling in the Presence of PCSK9 In Vitro.
Chem.Biol., 21, 2014
3E6F
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BU of 3e6f by Molmil
MHC CLASS I H-2Dd Heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PA9, from the Human immunodeficiency virus (BaL) envelope glycoprotein 120
分子名称: BETA-2 MICROGLOBULIN, Envelope glycoprotein 9-residue peptide, H-2 class I histocompatibility antigen, ...
著者Wang, R, Natarajan, K, Robinson, H, Margulies, D.H.
登録日2008-08-15
公開日2009-08-18
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity
J.Immunol., 183, 2009
3E6H
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BU of 3e6h by Molmil
MHC CLASS I H-2Dd heavy chain complexed with Beta-2 Microglobulin and a variant peptide, PI10, from the human immunodeficiency virus (BaL) envelope glycoprotein 120
分子名称: Envelope glycoprotein 10-residue peptide, H-2 class I histocompatibility antigen, D-D alpha chain, ...
著者Wang, R, Natarajan, K, Robinson, H, Margulies, D.H.
登録日2008-08-15
公開日2009-08-18
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Different vaccine vectors delivering the same antigen elicit CD8+ T cell responses with distinct clonotype and epitope specificity
J.Immunol., 183, 2009
4Y19
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BU of 4y19 by Molmil
immune complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FS18_alpha, FS18_beta, ...
著者Beringer, D.X, Petersen, J, Reid, H.H, Rossjohn, J.
登録日2015-02-07
公開日2015-09-23
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.
Nat.Immunol., 16, 2015
4Y1A
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BU of 4y1a by Molmil
immune complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FS17_alpha, FS17_beta, ...
著者Beringer, D.X, Vivian, J.P, Reid, H.H, Rossjohn, J.
登録日2015-02-07
公開日2015-09-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex.
Nat.Immunol., 16, 2015
4Z7U
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BU of 4z7u by Molmil
S13 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7W
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T316 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DQ8-glia-alpha1, MHC class II HLA-DQ-alpha chain, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
4Z7V
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BU of 4z7v by Molmil
L3-12 complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, MHC class II HLA-DQ-alpha chain, MHC class II HLA-DQ-beta-1, ...
著者Petersen, J, Rossjohn, J, Reid, H.H, Koning, F.
登録日2015-04-08
公開日2015-06-03
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Determinants of Gliadin-Specific T Cell Selection in Celiac Disease.
J Immunol., 194, 2015
6W0X
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BU of 6w0x by Molmil
Structure of KHK in complex with compound 4 (6-[(1~{S},5~{R})-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile)
分子名称: 6-[(1~{S},5~{R})-6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexan-3-yl]-2-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, Ketohexokinase, SULFATE ION
著者Jasti, J.
登録日2020-03-03
公開日2020-09-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
6W0Z
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Structure of KHK in complex with compound 8 (2-[(1~{S},5~{R})-3-[2-[(2~{S})-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid)
分子名称: 2-[(1~{S},5~{R})-3-[2-[(2~{S})-2-methylazetidin-1-yl]-6-(trifluoromethyl)pyrimidin-4-yl]-3-azabicyclo[3.1.0]hexan-6-yl]ethanoic acid, Ketohexokinase, SULFATE ION
著者Jasti, J.
登録日2020-03-03
公開日2020-09-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
6W0W
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Structure of KHK in complex with compound 3
分子名称: 6-[(3~{R},4~{S})-3,4-bis(oxidanyl)pyrrolidin-1-yl]-2-[(2~{S},3~{R})-2-methyl-3-oxidanyl-azetidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, Ketohexokinase, SULFATE ION
著者Jasti, J.
登録日2020-03-03
公開日2020-09-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
6W0N
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Structure of KHK in complex with compound 2
分子名称: 6-[(3~{S},4~{R})-3,4-bis(oxidanyl)pyrrolidin-1-yl]-2-[(3~{S})-3-methyl-3-oxidanyl-pyrrolidin-1-yl]-4-(trifluoromethyl)pyridine-3-carbonitrile, CITRIC ACID, Ketohexokinase, ...
著者Jasti, J.
登録日2020-03-02
公開日2020-09-23
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
J.Med.Chem., 63, 2020
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