5LAY
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![BU of 5lay by Molmil](/molmil-images/mine/5lay) | Discovery of New Natural-product-inspired Spiro-oxindole Compounds as Orally Active Inhibitors of the MDM2-p53 Interaction: HDM2 (MDM2) IN COMPLEX WITH COMPOUND 6g | 分子名称: | (3~{S},3'~{S},4'~{S},5'~{S})-4'-azanyl-6-chloranyl-3'-(3-chloranyl-2-fluoranyl-phenyl)-1'-[(3-ethoxyphenyl)methyl]-5'-methyl-spiro[1~{H}-indole-3,2'-pyrrolidine]-2-one, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ... | 著者 | Kessler, D, Gollner, A. | 登録日 | 2016-06-15 | 公開日 | 2016-11-02 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Discovery of Novel Spiro[3H-indole-3,2'-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2-p53 Interaction. J. Med. Chem., 59, 2016
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4HEB
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![BU of 4heb by Molmil](/molmil-images/mine/4heb) | The Crystal structure of Maf protein of Bacillus subtilis | 分子名称: | Septum formation protein Maf, UNKNOWN ATOM OR ION | 著者 | Dong, A, Dombrovski, L, Brown, G, Flick, R, Tchigvintsev, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Iakounine, A, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2012-10-03 | 公開日 | 2012-10-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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5E1S
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![BU of 5e1s by Molmil](/molmil-images/mine/5e1s) | The Crystal structure of INSR Tyrosine Kinase in complex with the Inhibitor BI 885578 | 分子名称: | (5R)-N-(1-{2-[4-(2-methoxyethyl)piperazin-1-yl]ethyl}-1H-pyrazol-3-yl)-5,8-dimethyl-9-phenyl-6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, Insulin receptor | 著者 | Kessler, D, Zahn, S, Sanderson, M, Wolkerstorfer, B. | 登録日 | 2015-09-30 | 公開日 | 2015-10-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.264 Å) | 主引用文献 | BI 885578, a Novel IGF1R/INSR Tyrosine Kinase Inhibitor with Pharmacokinetic Properties That Dissociate Antitumor Efficacy and Perturbation of Glucose Homeostasis. Mol.Cancer Ther., 14, 2015
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6OTT
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![BU of 6ott by Molmil](/molmil-images/mine/6ott) | Structure of PurF in complex with ppApp | 分子名称: | Amidophosphoribosyltransferase, PurF, MAGNESIUM ION, ... | 著者 | Grant, R.A, Wang, B, Laub, M.T. | 登録日 | 2019-05-03 | 公開日 | 2019-11-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | An interbacterial toxin inhibits target cell growth by synthesizing (p)ppApp. Nature, 575, 2019
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6P2M
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![BU of 6p2m by Molmil](/molmil-images/mine/6p2m) | Crystal structure of the Caldicellulosiruptor lactoaceticus GH74 (ClGH74a) enzyme in complex with LLG xyloglucan | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3,6,9,12,15,18,21,24,27,30,33,36,39-TRIDECAOXAHENTETRACONTANE-1,41-DIOL, GLYCEROL, ... | 著者 | Stogios, P.J, Skarina, T, Arnal, G. | 登録日 | 2019-05-21 | 公開日 | 2019-07-31 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74. J.Biol.Chem., 294, 2019
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6P2N
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![BU of 6p2n by Molmil](/molmil-images/mine/6p2n) | |
1MKI
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![BU of 1mki by Molmil](/molmil-images/mine/1mki) | Crystal Structure of Bacillus Subtilis Probable Glutaminase, APC1040 | 分子名称: | 1,2-ETHANEDIOL, FORMIC ACID, Probable Glutaminase ybgJ | 著者 | Kim, Y, Dementieva, I, Vinokour, E, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2002-08-29 | 公開日 | 2003-06-03 | 最終更新日 | 2017-10-11 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis. Biochemistry, 47, 2008
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2MA8
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![BU of 2ma8 by Molmil](/molmil-images/mine/2ma8) | Solution NMR Structure of Salmonella typhimurium LT2 Secreted Protein SrfN: Northeast Structural Genomics Consortium Target StR109 | 分子名称: | Putative secreted protein | 著者 | Cort, J.R, Eletsky, A, Adkins, J.N, Burnet, M.C, Parish, D, Liu, K, Sukumaran, D.K, Jiang, M, Cunningham, K, Ma, T, Xiao, R, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-06-29 | 公開日 | 2013-09-04 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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2MA4
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![BU of 2ma4 by Molmil](/molmil-images/mine/2ma4) | Solution NMR Structure of yahO protein from Salmonella typhimurium, Northeast Structural Genomics Consortium (NESG) Target StR106 | 分子名称: | Putative periplasmic protein | 著者 | Eletsky, A, Zhang, Q, Liu, G, Wang, H, Nwosu, C, Cunningham, K, Ma, L, Xiao, R, Liu, J, Baran, M.C, Swapna, G, Acton, T.B, Rost, B, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-06-27 | 公開日 | 2013-08-28 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and Functional Characterization of DUF1471 Domains of Salmonella Proteins SrfN, YdgH/SssB, and YahO. Plos One, 9, 2014
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2P5X
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![BU of 2p5x by Molmil](/molmil-images/mine/2p5x) | Crystal structure of Maf domain of human N-acetylserotonin O-methyltransferase-like protein | 分子名称: | N-acetylserotonin O-methyltransferase-like protein, PHOSPHATE ION | 著者 | Min, J, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | 登録日 | 2007-03-16 | 公開日 | 2007-03-27 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Biochemical and structural studies of conserved maf proteins revealed nucleotide pyrophosphatases with a preference for modified nucleotides. Chem.Biol., 20, 2013
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6UHX
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![BU of 6uhx by Molmil](/molmil-images/mine/6uhx) | Crystal structure of YIR035C short chain dehydrogenases/reductase from Saccharomyces cerevisiae | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Uncharacterized oxidoreductase YIR035C | 著者 | Stogios, P.J, Skarina, T, Chen, C, Kagan, O, Iakounine, A, Savchenko, A. | 登録日 | 2019-09-29 | 公開日 | 2020-08-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Crystal structure of YIR035C short chain dehydrogenases/reductase from Saccharomyces cerevisiae To Be Published
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4JM7
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![BU of 4jm7 by Molmil](/molmil-images/mine/4jm7) | 1.82 Angstrom resolution crystal structure of holo-(acyl-carrier-protein) synthase (acpS) from Staphylococcus aureus | 分子名称: | Holo-[acyl-carrier-protein] synthase | 著者 | Halavaty, A.S, Minasov, G, Shuvalova, L, Dubrovska, I, Papazisi, L, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2013-03-13 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.824 Å) | 主引用文献 | Structural characterization and comparison of three acyl-carrier-protein synthases from pathogenic bacteria. Acta Crystallogr.,Sect.D, 68, 2012
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3KZL
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![BU of 3kzl by Molmil](/molmil-images/mine/3kzl) | Crystal structure of BA2930 mutant (H183G) in complex with AcCoA | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYL COENZYME *A, Aminoglycoside N3-acetyltransferase, ... | 著者 | Klimecka, M.M, Chruszcz, M, Porebski, P.J, Cymborowski, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2009-12-08 | 公開日 | 2009-12-22 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis. J.Mol.Biol., 410, 2011
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1M6Y
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![BU of 1m6y by Molmil](/molmil-images/mine/1m6y) | Crystal Structure Analysis of TM0872, a Putative SAM-dependent Methyltransferase, Complexed with SAH | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, S-adenosyl-methyltransferase mraW, SULFATE ION | 著者 | Miller, D.J, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2002-07-17 | 公開日 | 2003-01-28 | 最終更新日 | 2016-03-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal complexes of a predicted S-adenosylmethionine-dependent methyltransferase reveal a typical AdoMet binding domain and a substrate recognition domain Protein Sci., 12, 2003
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3QXX
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![BU of 3qxx by Molmil](/molmil-images/mine/3qxx) | Crystal structure of dethiobiotin synthetase (BioD) from Helicobacter pylori complexed with GDP and 8-aminocaprylic acid | 分子名称: | 1,2-ETHANEDIOL, 8-aminooctanoic acid, Dethiobiotin synthetase, ... | 著者 | Porebski, P.J, Klimecka, M.M, Chruszcz, M, Murzyn, K, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2011-03-02 | 公開日 | 2011-03-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Structural characterization of Helicobacter pylori dethiobiotin synthetase reveals differences between family members. Febs J., 279, 2012
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3ETF
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![BU of 3etf by Molmil](/molmil-images/mine/3etf) | Crystal structure of a putative succinate-semialdehyde dehydrogenase from salmonella typhimurium lt2 | 分子名称: | Putative succinate-semialdehyde dehydrogenase | 著者 | Brunzelle, J.S, Evdokimova, E, Kudritska, M, Wawrzak, Z, Anderson, W.F, Savchenk, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2008-10-07 | 公開日 | 2008-11-04 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure and activity of the NAD(P)(+) -dependent succinate semialdehyde dehydrogenase YneI from Salmonella typhimurium. Proteins, 81, 2013
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3N0M
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![BU of 3n0m by Molmil](/molmil-images/mine/3n0m) | Crystal structure of BA2930 mutant (H183G) in complex with AcCoA | 分子名称: | ACETYL COENZYME *A, Aminoglycoside N3-acetyltransferase, CHLORIDE ION | 著者 | Klimecka, M.M, Chruszcz, M, Porebski, P.J, Cymborowski, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-05-14 | 公開日 | 2010-06-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis. J.Mol.Biol., 410, 2011
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4RHA
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![BU of 4rha by Molmil](/molmil-images/mine/4rha) | Structure of the C-terminal domain of outer-membrane protein OmpA from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Outer membrane protein A, ... | 著者 | Cuff, M.E, Skarina, T, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-10-01 | 公開日 | 2014-10-29 | 最終更新日 | 2019-12-04 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi. Protein Sci., 26, 2017
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3N0S
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![BU of 3n0s by Molmil](/molmil-images/mine/3n0s) | Crystal structure of BA2930 mutant (H183A) in complex with AcCoA | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETYL COENZYME *A, Aminoglycoside N3-acetyltransferase, ... | 著者 | Klimecka, M.M, Chruszcz, M, Porebski, P.J, Cymborowski, M, Anderson, W.F, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2010-05-14 | 公開日 | 2010-06-09 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Structural Analysis of a Putative Aminoglycoside N-Acetyltransferase from Bacillus anthracis. J.Mol.Biol., 410, 2011
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7RCA
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![BU of 7rca by Molmil](/molmil-images/mine/7rca) | Crystal structure of Aro2p chorismate synthase from Candida lusitaniae | 分子名称: | CHLORIDE ION, Chorismate synthase, SULFATE ION | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-07 | 公開日 | 2021-07-21 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | 主引用文献 | Crystal structure of Aro2p chorismate synthase from Candida lusitaniae To Be Published
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7REU
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![BU of 7reu by Molmil](/molmil-images/mine/7reu) | Crystal structure of Aro4p, 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase from Candida auris, L-Tyr complex | 分子名称: | 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, CHLORIDE ION, GLYCEROL, ... | 著者 | Stogios, P.J, Evdokimova, E, Tan, K, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-13 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | 主引用文献 | Crystal structure of Aro4p, 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase from Candida auris, L-Tyr complex To Be Published
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7RGE
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![BU of 7rge by Molmil](/molmil-images/mine/7rge) | Crystal structure of phosphoadenylyl-sulfate (PAPS) reductase from Candida auris, phosphate complex | 分子名称: | 3'-phosphoadenylylsulfate reductase, GLYCEROL, PHOSPHATE ION | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-15 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Crystal structure of phosphoadenylyl-sulfate (PAPS) reductase from Candida auris, phosphate complex To Be Published
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7RH8
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![BU of 7rh8 by Molmil](/molmil-images/mine/7rh8) | Crystal structure of Fur1p from Candida albicans, in complex with UTP | 分子名称: | URIDINE 5'-TRIPHOSPHATE, Uracil phosphoribosyltransferase | 著者 | Stogios, P.J, Skarina, T, Kim, Y, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-16 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Crystal structure of Fur1p from Candida albicans, in complex with UTP To Be Published
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7RJ1
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![BU of 7rj1 by Molmil](/molmil-images/mine/7rj1) | Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Chorismate mutase, ... | 著者 | Stogios, P.J, Evdokimova, E, Tan, K, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-20 | 公開日 | 2021-07-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Crystal structure of Aro7p chorismate mutase from Candida albicans, complex with L-Trp To Be Published
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7RLL
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![BU of 7rll by Molmil](/molmil-images/mine/7rll) | Crystal structure of ARF3 from Candida albicans in complex with guanosine-3'-monophosphate-5'-diphosphate | 分子名称: | Arf3p, GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE, MAGNESIUM ION | 著者 | Stogios, P.J, Michalska, K, Evdokimova, E, Di Leo, R, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2021-07-25 | 公開日 | 2021-08-11 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Crystal structure of ARF3 from Candida albicans in complex with guanosine-3'-monophosphate-5'-diphosphate To Be Published
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