8VEY
| |
8VET
| |
8VEU
| |
8VEW
| Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
|
|
8VEO
| Crystal structure of PRMT5:MEP50 in complex with MTA | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
|
|
3TL1
| Crystal structure of the Streptomyces coelicolor WhiE ORFVI polyketide aromatase/cyclase | 分子名称: | 6,7,9-trihydroxy-3-methyl-1H-benzo[g]isochromen-1-one, GLYCEROL, Polyketide cyclase | 著者 | Lee, M.-Y, Ames, B.D, Zhang, W, Tang, Y, Tsai, S.-C. | 登録日 | 2011-08-29 | 公開日 | 2012-04-04 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Insight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVI. Biochemistry, 51, 2012
|
|
8XQX
| Cryo-EM structure of the Ycf2-FtsHi motor complex from chlamydomonas reinhardtii in apo state | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ACP, ... | 著者 | Liang, K, Zhan, X, Wu, J, Yan, Z. | 登録日 | 2024-01-05 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae. Cell, 2024
|
|
8XQW
| Cryo-EM structure of the Ycf2-FtsHi motor complex from Chlamydomonas reinhardtii in AMPPNP bound state | 分子名称: | 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, ACP, ... | 著者 | Liang, K, Zhan, X, Wu, J, Yan, Z. | 登録日 | 2024-01-10 | 公開日 | 2024-09-11 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Conservation and specialization of the Ycf2-FtsHi chloroplast protein import motor in green algae. Cell, 2024
|
|
7CJF
| Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ... | 著者 | Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z. | 登録日 | 2020-07-10 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.108 Å) | 主引用文献 | A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun, 12, 2021
|
|
7XUP
| Crystal structure of TPe3.0 | 分子名称: | Transcriptional regulator, PadR-like family | 著者 | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | 登録日 | 2022-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.602 Å) | 主引用文献 | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
|
|
7XUQ
| Crystal structure of Tpe3.0 complexed with N-Boc-3-alkenylindole | 分子名称: | Transcriptional regulator, PadR-like family, dimethyl 2-[[2-methyl-1-[(2-methylpropan-2-yl)oxycarbonyl]indol-3-yl]methyl]-2-prop-2-enyl-propanedioate | 著者 | Chen, X, Qian, J.Y, Sun, N.N, Zhong, F.R, Wu, Y.Z. | 登録日 | 2022-05-19 | 公開日 | 2022-09-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Enantioselective [2+2]-cycloadditions with triplet photoenzymes. Nature, 611, 2022
|
|
7XZ4
| |
7YJ3
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with human ACE2 (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, Spike protein S1, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-07-19 | 公開日 | 2023-07-19 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
|
|
7YHW
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2.12.1 RBD in complex with human ACE2 (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Zhao, Z.N, Xie, Y.F, Qi, J.X, Gao, G.F. | 登録日 | 2022-07-14 | 公開日 | 2023-07-19 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
|
|
7YV8
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with golden hamster ACE2 (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme, Spike glycoprotein, ... | 著者 | Zhao, Z.N, Xie, Y.F, Chai, Y, Qi, J.X, Gao, G.F. | 登録日 | 2022-08-18 | 公開日 | 2023-07-19 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.94 Å) | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
|
|
7YVU
| Cryo-EM structure of SARS-CoV-2 Omicron BA.2 RBD in complex with mouse ACE2 (local refinement) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1, ... | 著者 | Zhao, Z.N, Xie, Y.F, Chai, Y, Qi, J.X, Gao, G.F. | 登録日 | 2022-08-19 | 公開日 | 2023-07-19 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural basis for receptor binding and broader interspecies receptor recognition of currently circulating Omicron sub-variants. Nat Commun, 14, 2023
|
|
7E2P
| The Crystal Structure of Mycoplasma bovis enolase | 分子名称: | Enolase | 著者 | Chen, R, Zhang, S, Gan, R, Wang, W, Ran, T, Shao, G, Xiong, Q, Feng, Z. | 登録日 | 2021-02-07 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases. Front Mol Biosci, 8, 2022
|
|
7E2Q
| Crystal structure of Mycoplasma pneumoniae Enolase | 分子名称: | Enolase, SULFATE ION | 著者 | Chen, R, Zhang, S, Gan, R, Wang, W, Ran, T, Xiong, Q, Shao, G, Feng, Z. | 登録日 | 2021-02-07 | 公開日 | 2022-02-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases. Front Mol Biosci, 8, 2022
|
|
7CWN
| P17-H014 Fab cocktail in complex with SARS-CoV-2 spike protein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Wang, N, Wang, X. | 登録日 | 2020-08-29 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection. Cell Res., 31, 2021
|
|
7YGI
| Crystal structure of p53 DBD domain in complex with azurin | 分子名称: | Azurin, Cellular tumor antigen p53, PHOSPHATE ION, ... | 著者 | Jiang, W.X, Zuo, J.Q, Hu, J.J, Chen, X.Q, Ma, L.X, Liu, Z, Xing, Q. | 登録日 | 2022-07-11 | 公開日 | 2023-02-08 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural basis of bacterial effector protein azurin targeting tumor suppressor p53 and inhibiting its ubiquitination. Commun Biol, 6, 2023
|
|
7X1N
| Crystal structure of MEF2D-MRE complex | 分子名称: | DNA (5'-D(P*AP*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*AP*G)-3'), DNA (5'-D(P*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), Myocyte enhancer factor 2D/deleted in azoospermia associated protein 1 fusion protein | 著者 | Zhang, H, Zhang, M, Wang, Q.Q, Chen, Z, Chen, S.J, Meng, G. | 登録日 | 2022-02-24 | 公開日 | 2022-05-25 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.315 Å) | 主引用文献 | Functional, structural, and molecular characterizations of the leukemogenic driver MEF2D-HNRNPUL1 fusion. Blood, 140, 2022
|
|
7CWO
| SARS-CoV-2 spike protein RBD and P17 fab complex | 分子名称: | Spike glycoprotein, heavy chain of P17 Fab, light chain of P17 Fab | 著者 | Wang, X, Wang, N. | 登録日 | 2020-08-29 | 公開日 | 2020-12-16 | 最終更新日 | 2021-01-13 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection. Cell Res., 31, 2021
|
|
7CWL
| |
7CWM
| |
5USG
| 5-Se-T2/4-DNA and native RNA hybrid in complex with RNase H catalytic domain D132N mutant | 分子名称: | DNA (5'-D(*AP*(T5S)P*GP*(T5S)P*CP*G)-3'), MAGNESIUM ION, RNA (5'-R(*UP*CP*GP*AP*CP*A)-3'), ... | 著者 | Fang, Z, Qin, L, Huang, Z. | 登録日 | 2017-02-13 | 公開日 | 2017-03-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Synthesis of Pyrimidine Modified Seleno-DNA as a Novel Approach to Antisense Candidate Chemistryselect, 8, 2023
|
|