2E4R
 
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2EJK
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3E20
 | | Crystal structure of S.pombe eRF1/eRF3 complex | | 分子名称: | Eukaryotic peptide chain release factor GTP-binding subunit, Eukaryotic peptide chain release factor subunit 1 | | 著者 | Cheng, Z, Lim, M, Kong, C, Song, H. | | 登録日 | 2008-08-05 | | 公開日 | 2009-05-19 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | | 主引用文献 | Structural insights into eRF3 and stop codon recognition by eRF1
Genes Dev., 23, 2009
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2EMU
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2EN5
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2EH2
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2PC8
 | | E292Q mutant of EXO-B-(1,3)-Glucanase from Candida Albicans in complex with two separately bound glucopyranoside units at 1.8 A | | 分子名称: | Hypothetical protein XOG1, beta-D-glucopyranose | | 著者 | Cutfield, S.M, Cutfield, J.F, Patrick, W.M. | | 登録日 | 2007-03-29 | | 公開日 | 2008-04-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Carbohydrate binding sites in Candida albicans exo-beta-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance.
Febs J., 277, 2010
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2LDS
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2PF0
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3IIT
 | | Factor XA in complex with a cis-1,2-diaminocyclohexane derivative | | 分子名称: | 7-chloro-N-[(1S,2R,4S)-4-(dimethylcarbamoyl)-2-{[(5-methyl-5,6-dihydro-4H-pyrrolo[3,4-d][1,3]thiazol-2-yl)carbonyl]amino}cyclohexyl]isoquinoline-3-carboxamide, Activated factor Xa heavy chain, CALCIUM ION, ... | | 著者 | Suzuki, M. | | 登録日 | 2009-08-03 | | 公開日 | 2010-08-04 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: exploration of 6-6 fused rings as alternative S1 moieties.
Bioorg.Med.Chem., 17, 2009
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5B5O
 | | Crystal structure of the catalytic domain of MMP-13 complexed with N-phenyl-4-((4H-1,2,4-triazol-3-ylsulfanyl)methyl)-1,3-thiazol-2-amine | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, Collagenase 3, ... | | 著者 | Oki, H, Tanaka, Y. | | 登録日 | 2016-05-13 | | 公開日 | 2017-01-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | | 主引用文献 | Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 60, 2017
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5B5P
 | | Crystal structure of the catalytic domain of MMP-13 complexed with 4-oxo-N-(3-(2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy)benzyl)-3,4-dihydroquinazoline-2-carboxamide | | 分子名称: | 4-oxo-N-{3-[2-(1H-1,2,4-triazol-3-ylsulfanyl)ethoxy]benzyl}-3,4-dihydroquinazoline-2-carboxamide, CALCIUM ION, Collagenase 3, ... | | 著者 | Oki, H, Tanaka, Y. | | 登録日 | 2016-05-13 | | 公開日 | 2017-01-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery of Novel, Highly Potent, and Selective Matrix Metalloproteinase (MMP)-13 Inhibitors with a 1,2,4-Triazol-3-yl Moiety as a Zinc Binding Group Using a Structure-Based Design Approach
J. Med. Chem., 60, 2017
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4P5I
 | | Crystal structure of the chemokine binding protein from orf virus | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chemokine binding protein | | 著者 | Counago, R.M, Krause, K.L. | | 登録日 | 2014-03-17 | | 公開日 | 2015-07-15 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structures of Orf Virus Chemokine Binding Protein in Complex with Host Chemokines Reveal Clues to Broad Binding Specificity.
Structure, 23, 2015
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1BAV
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8GOH
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8GOI
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8II1
 | | Crystal structure of V30M-TTR in complex with BID | | 分子名称: | Benziodarone, Transthyretin | | 著者 | Yokoyama, T. | | 登録日 | 2023-02-24 | | 公開日 | 2023-06-28 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.907 Å) | | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
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8II3
 | | Crystal structure of V30M-TTR in complex with 6-hydroxy BID | | 分子名称: | Transthyretin, [3,5-bis(iodanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | | 著者 | Yokoyama, T. | | 登録日 | 2023-02-24 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.399 Å) | | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
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8II2
 | | Crystal structure of V30M-TTR in complex with BBM | | 分子名称: | CALCIUM ION, Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone | | 著者 | Yokoyama, T. | | 登録日 | 2023-02-24 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
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8II4
 | | Crystal structure of V30M-TTR in complex with 6-hydroxy BBM | | 分子名称: | Transthyretin, [3,5-bis(bromanyl)-4-oxidanyl-phenyl]-(2-ethyl-6-oxidanyl-1-benzofuran-3-yl)methanone | | 著者 | Yokoyama, T. | | 登録日 | 2023-02-24 | | 公開日 | 2023-06-28 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.499 Å) | | 主引用文献 | Benziodarone and 6-hydroxybenziodarone are potent and selective inhibitors of transthyretin amyloidogenesis.
Bioorg.Med.Chem., 90, 2023
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8HRH
 | | SN-131/1B2 anti-MUC1 antibody with a glycopeptide | | 分子名称: | 1-ACETYL-L-PROLINE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ALANINE, ... | | 著者 | Wakui, H, Horidome, C, Yao, M, Ose, T, Nishimura, S.-I. | | 登録日 | 2022-12-15 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Structural and molecular insight into antibody recognition of dynamic neoepitopes in membrane tethered MUC1 of pancreatic cancer cells and secreted exosomes.
Rsc Chem Biol, 4, 2023
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8IG1
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7W9Q
 | | Crystal structure of V30M-TTR in complex with naringenin derivative-14 | | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
J.Med.Chem., 65, 2022
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7W9R
 | | Crystal structure of V30M-TTR in complex with naringenin derivative-18 | | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | | 登録日 | 2021-12-10 | | 公開日 | 2022-12-14 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis.
J.Med.Chem., 65, 2022
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4EH3
 | | Human p38 MAP kinase in complex with NP-F2 and RL87 | | 分子名称: | Mitogen-activated protein kinase 14, NARINGENIN, N~4~-cyclopropyl-2-phenylquinazoline-4,7-diamine | | 著者 | Over, B, Gruetter, C, Waldmann, H, Rauh, D. | | 登録日 | 2012-04-02 | | 公開日 | 2012-12-05 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Natural-product-derived fragments for fragment-based ligand discovery.
Nat Chem, 5, 2012
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