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4KSQ
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BU of 4ksq by Molmil
Crystal Structure of Human B-raf bound to a DFG-out Inhibitor 5B
分子名称: N-{7-cyano-6-[4-fluoro-3-({[3-(trifluoromethyl)phenyl]carbamoyl}amino)phenoxy]-1,3-benzothiazol-2-yl}cyclopropanecarboxamide, Serine/threonine-protein kinase B-raf
著者Yano, J.K, Masanori, O.
登録日2013-05-17
公開日2013-07-24
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Discovery of a Selective Kinase Inhibitor (TAK-632) Targeting Pan-RAF Inhibition: Design, Synthesis, and Biological Evaluation of C-7-Substituted 1,3-Benzothiazole Derivatives.
J.Med.Chem., 56, 2013
1IQH
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BU of 1iqh by Molmil
Human coagulation factor Xa in complex with M55143
分子名称: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQK
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BU of 1iqk by Molmil
Human coagulation factor Xa in complex with M55113
分子名称: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IXD
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BU of 1ixd by Molmil
Solution structure of the CAP-GLY domain from human cylindromatosis tomour-suppressor CYLD
分子名称: Cylindromatosis tumour-suppressor CYLD
著者Saito, K, Koshiba, S, Kigawa, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
登録日2002-06-19
公開日2002-12-19
最終更新日2023-12-27
実験手法SOLUTION NMR
主引用文献The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma
STRUCTURE, 12, 2004
1IQI
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BU of 1iqi by Molmil
Human coagulation factor Xa in complex with M55125
分子名称: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL] METHYL]-2-PIPERAZINECARBOXYLIC ACID, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1V3J
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BU of 1v3j by Molmil
Crystal structure of F283L mutant cyclodextrin glycosyltransferase
分子名称: CALCIUM ION, Cyclomaltodextrin glucanotransferase
著者Kanai, R, Haga, K, Akiba, T, Yamane, K, Harata, K.
登録日2003-11-03
公開日2004-08-03
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site
PROTEIN SCI., 13, 2004
1V3L
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BU of 1v3l by Molmil
Crystal structure of F283L mutant cyclodextrin glycosyltransferase complexed with a pseudo-tetraose derived from acarbose
分子名称: 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-alpha-D-glucopyranose, 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-beta-D-galactopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, ...
著者Kanai, R, Haga, K, Akiba, T, Yamane, K, Harata, K.
登録日2003-11-03
公開日2004-08-03
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site
PROTEIN SCI., 13, 2004
4XD9
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BU of 4xd9 by Molmil
Structure of Rpf2-Rrs1 complex involved in ribosome biogenesis
分子名称: Ribosome biogenesis protein (Rrs1), putative (AFU_orthologue AFUA_7G04430), Ribosome biogenesis protein, ...
著者Asano, N, Kato, K, Yao, M.
登録日2014-12-19
公開日2015-06-10
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural and functional analysis of the Rpf2-Rrs1 complex in ribosome biogenesis.
Nucleic Acids Res., 43, 2015
5EN6
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BU of 5en6 by Molmil
Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans
分子名称: SMU-1, Suppressor of Mec and Unc defects
著者Ulrich, A.K.C, Wahl, M.C.
登録日2015-11-09
公開日2016-04-20
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (3.103 Å)
主引用文献Crystal structure of the Smu1-RED complex (SeMet) of Caenorhabditis elegans
to be published
5EN7
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BU of 5en7 by Molmil
Crystal structure of the Smu1-RED complex (native) of Caenorhabditis elegans.
分子名称: SMU-1, Suppressor of Mec and Unc defects
著者Ulrich, A.K.C, Wahl, M.C.
登録日2015-11-09
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.936 Å)
主引用文献splicing factor
to be published
1IOE
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BU of 1ioe by Molmil
Human coagulation factor Xa in complex with M55532
分子名称: (-)-7-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]TETRAHYDRO-8A-(METHOXYMETHYL)-1'-(4-PYRIDINYL)-SPIRO[5H-OXAZOLO[3,2-A]PYRAZINE-2(3H),4'-PIPERIDIN]-5-ONE, CALCIUM ION, COAGULATION FACTOR XA
著者Shiromizu, I, Matsusue, T.
登録日2001-03-08
公開日2003-09-23
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Factor Xa Specific Inhibitor That Induces the Novel Binding Model In Complex With Human FXa
To be Published
4NA1
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BU of 4na1 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase
分子名称: Polyketide synthase PksJ, SULFATE ION
著者Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
登録日2013-10-21
公開日2014-02-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
4NA2
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BU of 4na2 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to its natural intermediate
分子名称: Polyketide synthase PksJ
著者Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
登録日2013-10-21
公開日2014-02-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
5EN8
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BU of 5en8 by Molmil
Crystal structure of the N-terminal region of Smu1
分子名称: SMU-1
著者Ulrich, A.K.C, Wahl, M.C.
登録日2015-11-09
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Crystal structure of the N-terminal region of Smu1
to be published
4LYN
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BU of 4lyn by Molmil
Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3-thiazol-2-yl)-2-phenylpropanamide
分子名称: (2S)-N-(5-{[(5-tert-butyl-1,3-oxazol-2-yl)methyl]sulfanyl}-1,3-thiazol-2-yl)-2-phenylpropanamide, Cyclin-dependent kinase 2
著者Sack, J.S.
登録日2013-07-31
公開日2013-10-02
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of Aminothiazole Inhibitors of Cyclin-Dependent Kinase 2: Synthesis, X-Ray Crystallographic Analysis, and Biological Activities
J.Med.Chem., 45, 2002
6UIP
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BU of 6uip by Molmil
DYRK1A Kinase Domain in Complex with a 6-azaindole Derivative, GNF2133.
分子名称: 4-ethyl-N-{4-[1-(oxan-4-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]pyridin-2-yl}piperazine-1-carboxamide, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
著者DiDonato, M, Spraggon, G.
登録日2019-10-01
公開日2020-03-04
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J.Med.Chem., 63, 2020
1IQJ
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BU of 1iqj by Molmil
Human coagulation factor Xa in complex with M55124
分子名称: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINECARBOXYLIC ACID ETHYL ESTER, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQE
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BU of 1iqe by Molmil
Human coagulation factor Xa in complex with M55590
分子名称: 4-[(2R)-3-[[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]AMINO]-1-OXO-2-[[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]AMINO]PROPYL]-THIOMORPHOLINE-1,1-DIOXIDE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-11-20
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQM
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BU of 1iqm by Molmil
Human coagulation factor Xa in complex with M54471
分子名称: 1-[[(1E)-2-(4-CHLOROPHENYL)ETHENYL]SULFONYL]-4-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
4NA3
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BU of 4na3 by Molmil
Crystal Structure of the second ketosynthase from the bacillaene polyketide synthase bound to a hexanoyl substrate mimic
分子名称: Polyketide synthase PksJ, SULFATE ION
著者Gay, D.C, Gay, G.R, Keatinge-Clay, A.T.
登録日2013-10-21
公開日2014-02-19
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
Structure, 22, 2014
5DST
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BU of 5dst by Molmil
Crystal structure of human PRMT8 in complex with SAH
分子名称: Protein arginine N-methyltransferase 8, S-ADENOSYL-L-HOMOCYSTEINE
著者Toma-Fukai, S, Shimizu, T.
登録日2015-09-17
公開日2016-02-24
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.963 Å)
主引用文献Novel helical assembly in arginine methyltransferase 8
J.Mol.Biol., 428, 2016
1V3K
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BU of 1v3k by Molmil
Crystal structure of F283Y mutant cyclodextrin glycosyltransferase
分子名称: CALCIUM ION, Cyclomaltodextrin glucanotransferase
著者Kanai, R, Haga, K, Akiba, T, Yamane, K, Harata, K.
登録日2003-11-03
公開日2004-08-03
最終更新日2024-10-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: substrate binding and arrangement of the catalytic site
PROTEIN SCI., 13, 2004
1V3M
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BU of 1v3m by Molmil
Crystal structure of F283Y mutant cyclodextrin glycosyltransferase complexed with a pseudo-tetraose derived from acarbose
分子名称: 4,6-dideoxy-alpha-D-xylo-hexopyranose-(1-4)-beta-D-galactopyranose, 6-AMINO-4-HYDROXYMETHYL-CYCLOHEX-4-ENE-1,2,3-TRIOL, CALCIUM ION, ...
著者Kanai, R, Haga, K, Akiba, T, Yamane, K, Harata, K.
登録日2003-11-03
公開日2004-08-03
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Role of Phe283 in enzymatic reaction of cyclodextrin glycosyltransferase from alkalophilic Bacillus sp.1011: Substrate binding and arrangement of the catalytic site
PROTEIN SCI., 13, 2004
1IQG
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BU of 1iqg by Molmil
Human coagulation factor Xa in complex with M55159
分子名称: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQN
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BU of 1iqn by Molmil
Human coagulation factor Xa in complex with M55192
分子名称: 4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE, CALCIUM ION, coagulation Factor Xa
著者Shiromizu, I, Matsusue, T.
登録日2001-07-23
公開日2003-09-23
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published

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件を2025-07-09に公開中

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