8XN7
| Crystal structure of HPK1 kinase domain T165E,S171E phosphomimetic mutant in complex with compound 9f | 分子名称: | 5-amino-2-((6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl)amino)-8-(2-(trifluoromethyl)benzyl)pyrido[2,3-d]pyrimidin-7(8H)-one, Mitogen-activated protein kinase kinase kinase kinase 1 | 著者 | Huang, W.X, Liu, R, Ding, K. | 登録日 | 2023-12-29 | 公開日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur.J.Med.Chem., 269, 2024
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1TFR
| RNASE H FROM BACTERIOPHAGE T4 | 分子名称: | MAGNESIUM ION, T4 RNASE H | 著者 | Mueser, T.C, Nossal, N.G, Hyde, C.C. | 登録日 | 1996-04-27 | 公開日 | 1996-11-08 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins. Cell(Cambridge,Mass.), 85, 1996
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7T0D
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2k | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-propyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.906 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0C
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2e | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-chlorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.903 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0E
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2b | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-(3-chlorophenyl)piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.223 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0B
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2g | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-5-butyl-4-({1-[(4-fluorophenyl)methyl]-1H-imidazol-5-yl}methyl)-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.026 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T0A
| Cryptococcus neoformans protein farnesyltransferase co-crystallized with FPP and inhibitor 2f | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one, 1,2-ETHANEDIOL, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T09
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2d | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}benzonitrile, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.984 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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7T08
| Cryptococcus neoformans protein farnesyltransferase in complex with FPP and inhibitor 2q | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 1,2-ETHANEDIOL, 4-{[5-({(2S)-2-butyl-5-oxo-4-[3-(trifluoromethoxy)phenyl]piperazin-1-yl}methyl)-1H-imidazol-1-yl]methyl}-2-fluorobenzonitrile, ... | 著者 | Wang, Y, Shi, Y, Beese, L.S. | 登録日 | 2021-11-29 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | 主引用文献 | Structure-Guided Discovery of Potent Antifungals that Prevent Ras Signaling by Inhibiting Protein Farnesyltransferase. J.Med.Chem., 65, 2022
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6ZJW
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6ZJX
| Cold-adapted beta-D-galactosidase from Arthrobacter sp. 32cB mutant D207A in complex with saccharose | 分子名称: | ACETATE ION, Beta-galactosidase, MALONATE ION, ... | 著者 | Rutkiewicz, M, Bujacz, A, Bujacz, G. | 登録日 | 2020-06-29 | 公開日 | 2020-08-05 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Mapping the Transglycosylation Relevant Sites of Cold-Adapted beta-d-Galactosidase fromArthrobactersp. 32cB. Int J Mol Sci, 21, 2020
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1KXU
| CYCLIN H, A POSITIVE REGULATORY SUBUNIT OF CDK ACTIVATING KINASE | 分子名称: | CYCLIN H | 著者 | Kim, K.K, Chamberin, H.M, Morgan, D.O, Kim, S.-H. | 登録日 | 1996-08-08 | 公開日 | 1997-01-27 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Three-dimensional structure of human cyclin H, a positive regulator of the CDK-activating kinase. Nat.Struct.Biol., 3, 1996
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6ZJV
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6ZJP
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4MO7
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4EZ9
| Bacillus DNA Polymerase I Large Fragment Complex 2 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*AP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... | 著者 | Wang, W, Beese, L.S. | 登録日 | 2012-05-02 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structures of a High-fidelity DNA Polymerase to be published
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4F3O
| DNA Polymerase I Large Fragment Complex 5 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*AP*TP*GP*AP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... | 著者 | Wang, W, Beese, L.S. | 登録日 | 2012-05-09 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Structures of a High-fidelity DNA Polymerase to be published
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4F8R
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4MXM
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4JZ0
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4DSE
| Ternary complex of Bacillus DNA Polymerase I Large Fragment F710Y, DNA duplex, and rCTP (paired with dG of template) in presence of Mg2+ | 分子名称: | CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*GP*GP*GP*AP*GP*TP*CP*AP*GP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*TP*CP*(DOC))-3'), ... | 著者 | Wang, W, Beese, L.S. | 登録日 | 2012-02-18 | 公開日 | 2012-06-06 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structural factors that determine selectivity of a high fidelity DNA polymerase for deoxy-, dideoxy-, and ribonucleotides. J.Biol.Chem., 287, 2012
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4EZ6
| Bacillus DNA Polymerase I Large Fragment Complex 1 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*GP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... | 著者 | Wang, W, Beese, L.S. | 登録日 | 2012-05-02 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Structures of a High-fidelity DNA Polymerase to be published
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4F4K
| DNA Polymerase I Large Fragment Complex 6 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2'-3'-DIDEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*TP*TP*CP*GP*AP*GP*TP*CP*AP*GP*G)-3'), ... | 著者 | Wang, W, Beese, L.S. | 登録日 | 2012-05-10 | 公開日 | 2013-07-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structures of a High-fidelity DNA Polymerase to be published
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4JYW
| X-ray structure of human glutamate carboxypeptidase II (GCPII) in complex with CTT1057 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Barinka, C. | 登録日 | 2013-04-01 | 公開日 | 2014-04-02 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | A high affinity 18F-labeled phosphoramidate peptidomimetic inhibitor as a PSMA-targeted PET imaging agent for prostate cancer To be Published
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3E3F
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