2B4K
 
 | | Acetobacter turbidans alpha-amino acid ester hydrolase complexed with phenylglycine | | 分子名称: | Alpha-amino acid ester hydrolase, D-PHENYLGLYCINE, GLYCEROL | | 著者 | Barends, T.R.M, Polderman-Tijmes, J.J, Jekel, P.A, Williams, C, Wybenga, G, Janssen, D.B, Dijkstra, B.W. | | 登録日 | 2005-09-26 | | 公開日 | 2005-12-27 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Acetobacter turbidans alpha-amino acid ester hydrolase: how a single mutation improves an antibiotic-producing enzyme.
J.Biol.Chem., 281, 2006
|
|
2PNG
 | | Type I rat fatty acid synthase acyl carrier protein (ACP) domain | | 分子名称: | Fatty acid synthase (EC 2.3.1.85) | | 著者 | Ploskon, E.A, Arthur, C.J, Evans, S.E, Williams, C, Crosby, J, Crump, M.P. | | 登録日 | 2007-04-24 | | 公開日 | 2007-06-05 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A Mammalian type I Fatty Acid synthase acyl carrier protein domain does not sequester acyl chains.
J.Biol.Chem., 283, 2008
|
|
2MVV
 | | Solution Structure of the 5-phenyl-3-oxo-pentyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3-oxo-5-phenylpentyl)sulfanyl]ethyl}-beta-alaninamide | | 著者 | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | | 登録日 | 2014-10-15 | | 公開日 | 2015-10-21 | | 実験手法 | SOLUTION NMR | | 主引用文献 | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates
To be Published
|
|
2MVU
 | | Solution Structure of the 3,7-dioxo-octyl Actinorhodin Acyl Carrier Protein from Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-{(2S)-4-[(dihydroxyphosphanyl)oxy]-2-hydroxy-3,3-dimethylbutanoyl}-N-{2-[(3,7-dioxooctyl)sulfanyl]ethyl}-beta-alaninamide | | 著者 | Dong, X, Bailey, C, Williams, C, Crosby, J, Simpson, T.J, Willis, C.L, Crump, M.P. | | 登録日 | 2014-10-15 | | 公開日 | 2015-10-21 | | 実験手法 | SOLUTION NMR | | 主引用文献 | ACP-ligand recognition: Selection of derivatized aromatic biosynthetic intermediates
To be Published
|
|
4C26
 | | Solution NMR structure of the HicA toxin from Burkholderia pseudomallei | | 分子名称: | HICA | | 著者 | Butt, A, Higman, V.A, Williams, C, Crump, M.P, Hemsley, C, Harmer, N, Titball, R.W. | | 登録日 | 2013-08-16 | | 公開日 | 2014-04-23 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Hica Toxin from Burkholderia Pseudomallei Has a Role in Persister Cell Formation.
Biochem.J., 459, 2014
|
|
2L22
 | |
2LPC
 | | NMR STRUCTURE of Bcl-XL | | 分子名称: | Bcl-2-like protein 1 | | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | | 登録日 | 2012-02-09 | | 公開日 | 2012-03-21 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).
J.Am.Chem.Soc., 134, 2012
|
|
2M68
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R in complex with IGF2 (domain 11 structure only) | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-03-27 | | 公開日 | 2014-10-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
2JOL
 | | Average NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | | 分子名称: | Putative G-nucleotide exchange factor | | 著者 | Wu, H, Upadhyay, A, Williams, C, Galyov, E.E, van den Elsen, J.M.H, Bagby, S. | | 登録日 | 2007-03-14 | | 公開日 | 2007-03-27 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42
Biochem.J., 411, 2008
|
|
2JOK
 | | NMR structure of the catalytic domain of guanine nucleotide exchange factor BopE from Burkholderia pseudomallei | | 分子名称: | Putative G-nucleotide exchange factor | | 著者 | Wu, H, Upadhyay, A, Williams, C, Galyov, E.E, van den Elsen, J.M.H, Bagby, S. | | 登録日 | 2007-03-14 | | 公開日 | 2007-09-18 | | 最終更新日 | 2023-12-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The guanine-nucleotide-exchange factor BopE from Burkholderia pseudomallei adopts a compact version of the Salmonella SopE/SopE2 fold and undergoes a closed-to-open conformational change upon interaction with Cdc42
Biochem.J., 411, 2008
|
|
2KGD
 | | NMR Solution Structures of 3-oxo-butyl-ACP, an intermediate mimic from the actinorhodin polyketide synthase in Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-{2-[(3-oxobutyl)sulfanyl]ethyl}-beta-alaninamide | | 著者 | Crump, M.P, Evans, S.E, Williams, C. | | 登録日 | 2009-03-08 | | 公開日 | 2009-04-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
J.Mol.Biol., 389, 2009
|
|
2KG8
 | | NMR Solution Structures of malonyl ACP from the actinorhodin polyketide synthase in Streptomyces coelicolor | | 分子名称: | 3-{[2-({N-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alanyl}amino)ethyl]sulfanyl}-3-oxopropanoic acid, Actinorhodin polyketide synthase acyl carrier protein | | 著者 | Crump, M.P, Evans, S.E, Williams, C, Eliza, P. | | 登録日 | 2009-03-06 | | 公開日 | 2009-04-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
J.Mol.Biol., 389, 2009
|
|
2KGA
 | |
2KG9
 | | NMR Solution Structures of butyryl-ACP (a non-polar, non pathway intermediate) from the actinorhodin polyketide synthase in Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, THIOBUTYRIC ACID S-{2-[3-(2-HYDROXY-3,3-DIMETHYL-4-PHOSPHONOOXY-BUTYRYLAMINO)-PROPIONYLAMINO]-ETHYL} ESTER | | 著者 | Crump, M.P, Evans, S.E, Williams, C. | | 登録日 | 2009-03-07 | | 公開日 | 2009-04-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
J.Mol.Biol., 389, 2009
|
|
2KGE
 | | NMR Solution Structures of 3,5-dioxohexyl ACP (a triketide mimic) from the actinorhodin polyketide synthase in Streptomyces coelicolor | | 分子名称: | Actinorhodin polyketide synthase acyl carrier protein, N-{2-[(3,5-dioxohexyl)sulfanyl]ethyl}-N~3~-[(2S)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-beta-alaninamide | | 著者 | Crump, M.P, Evans, S.E, Williams, C. | | 登録日 | 2009-03-08 | | 公開日 | 2009-04-14 | | 最終更新日 | 2021-10-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Probing the Interactions of Early Polyketide Intermediates with the Actinorhodin ACP from S. coelicolor A3(2).
J.Mol.Biol., 389, 2009
|
|
2KR5
 | | Solution Structure of an Acyl Carrier Protein Domain from Fungal Type I Polyketide Synthase | | 分子名称: | 4'-PHOSPHOPANTETHEINE, Aflatoxin biosynthesis polyketide synthase | | 著者 | Wattana-amorn, P, Williams, C, Ploskon, E, Cox, R.J, Simpson, T.J, Crosby, J, Crump, M.P. | | 登録日 | 2009-12-03 | | 公開日 | 2010-03-02 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase.
Biochemistry, 49, 2010
|
|
2M6T
 | | NMR solution structure ensemble of 3-4D mutant domain 11 IGF2R | | 分子名称: | Insulin-like growth factor 2 receptor variant | | 著者 | Strickland, M, Williams, C, Richards, E, Minnall, L, Crump, M.P, Frago, S, Hughes, J, Garner, L, Hoppe, H, Rezgui, D, Zaccheo, O.J, Prince, S.N, Hassan, A.B, Whittaker, S. | | 登録日 | 2013-04-09 | | 公開日 | 2014-10-15 | | 最終更新日 | 2016-06-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Functional evolution of IGF2:IGF2R domain 11 binding generates novel structural interactions and a specific IGF2 antagonist.
Proc.Natl.Acad.Sci.USA, 113, 2016
|
|
2KGC
 | |
2LP8
 | | SOLUTION STRUCTURE OF AN APOPTOSIS ACTIVATING PHOTOSWITCHABLE BAK PEPTIDE BOUND to BCL-XL | | 分子名称: | 3,3'-(E)-diazene-1,2-diylbis{6-[(chloroacetyl)amino]benzenesulfonic acid}, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1 | | 著者 | Wysoczanski, P, Mart, R.J, Loveridge, J.E, Williams, C, Whittaker, S.B.-M, Crump, M.P, Allemann, R.K. | | 登録日 | 2012-02-03 | | 公開日 | 2012-04-18 | | 最終更新日 | 2021-08-18 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR Solution Structure of a Photoswitchable Apoptosis Activating Bak Peptide Bound to Bcl-x(L).
J.Am.Chem.Soc., 134, 2012
|
|
4ZMJ
 | | Crystal Structure of Ligand-Free BG505 SOSIP.664 HIV-1 Env Trimer | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | | 著者 | Kwon, Y.D, Kwong, P.D. | | 登録日 | 2015-05-04 | | 公開日 | 2015-06-24 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (3.31 Å) | | 主引用文献 | Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.
Nat.Struct.Mol.Biol., 22, 2015
|
|
3FL4
 | | P38 kinase crystal structure in complex with RO5634 | | 分子名称: | 6-(2,4-difluorophenoxy)-3-(2-methylphenyl)-1H-pyrazolo[3,4-d]pyrimidine, Mitogen-activated protein kinase 14 | | 著者 | Kuglstatter, A, Knapp, M. | | 登録日 | 2008-12-18 | | 公開日 | 2009-12-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity
To be Published
|
|
3FSK
 | | P38 kinase crystal structure in complex with RO6257 | | 分子名称: | 3-(2-chlorophenyl)-7-[(trans-4-hydroxycyclohexyl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Mitogen-activated protein kinase 14 | | 著者 | Kuglstatter, A, Bertrand, J, Takahara, P, Villasenor, A. | | 登録日 | 2009-01-09 | | 公開日 | 2009-12-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Mapping Binding Pocket Volume: Potential Applications towards Ligand Design and Selectivity
To be Published
|
|
5Y08
 | |
7AH0
 | | Crystal structure of the de novo designed two-heme binding protein, 4D2 | | 分子名称: | 4D2, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Hutchins, G.H, Parnell, A.E, Anderson, J.L.R. | | 登録日 | 2020-09-23 | | 公開日 | 2021-10-06 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | An expandable, modular de novo protein platform for precision redox engineering.
Proc.Natl.Acad.Sci.USA, 120, 2023
|
|
8CCR
 | |
