4PLB
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![BU of 4plb by Molmil](/molmil-images/mine/4plb) | Crystal Structure of S.A. gyrase-AM8191 complex | 分子名称: | 6-[({(1r,4S)-1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, Chimera protein of DNA gyrase subunits B and A, DNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), ... | 著者 | Lu, J, Patel, S, Soisson, S. | 登録日 | 2014-05-16 | 公開日 | 2014-06-18 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents. Acs Med.Chem.Lett., 5, 2014
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5BS3
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![BU of 5bs3 by Molmil](/molmil-images/mine/5bs3) | Crystal Structure of S.A. gyrase in complex with Compound 7 | 分子名称: | (4R)-3-fluoro-4-hydroxy-4-{[(1r,4R)-4-{[(3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methyl]amino}-2-oxabicyclo[2.2.2]oct-1-yl]methyl}-4,5-dihydro-7H-pyrrolo[3,2,1-de][1,5]naphthyridin-7-one, DNA gyrase subunit A and B, DNA/RNA (5'-R(P*AP*GP*CP*CP*G)-D(P*T)-R(P*AP*GP*GP*GP*CP*CP*C)-D(P*T)-R(P*AP*CP*GP*GP*C)-D(P*T)-3'), ... | 著者 | Lu, J, Patel, S, Soisson, S. | 登録日 | 2015-06-01 | 公開日 | 2015-06-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2). Bioorg.Med.Chem.Lett., 25, 2015
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6J1O
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6J46
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![BU of 6j46 by Molmil](/molmil-images/mine/6j46) | LepI-SAH complex structure | 分子名称: | O-methyltransferase lepI, S-ADENOSYL-L-HOMOCYSTEINE | 著者 | Qiu, S, Wei, C. | 登録日 | 2019-01-08 | 公開日 | 2019-05-01 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.621 Å) | 主引用文献 | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme. Signal Transduct Target Ther, 4, 2019
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6J24
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![BU of 6j24 by Molmil](/molmil-images/mine/6j24) | Crystal structure of a SAM-dependent methyltransferase LepI in complex with its substrate | 分子名称: | (3~{S},4'~{R},4'~{a}~{S},6'~{R},8'~{a}~{S})-4',6'-dimethyl-5-phenyl-spiro[1~{H}-pyridine-3,5'-2,3,4,4~{a},6,8~{a}-hexahydro-1~{H}-naphthalene]-2,4-dione, O-methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Qiu, S, Wei, C. | 登録日 | 2018-12-30 | 公開日 | 2019-05-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.244 Å) | 主引用文献 | Deciphering the regulatory and catalytic mechanisms of an unusual SAM-dependent enzyme. Signal Transduct Target Ther, 4, 2019
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3T8M
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8IF8
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![BU of 8if8 by Molmil](/molmil-images/mine/8if8) | Arabinosyltransferase AftA | 分子名称: | CALCIUM ION, Galactan 5-O-arabinofuranosyltransferase | 著者 | Gong, Y.C, Rao, Z.H, Zhang, L. | 登録日 | 2023-02-17 | 公開日 | 2023-05-31 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structure of the priming arabinosyltransferase AftA required for AG biosynthesis of Mycobacterium tuberculosis. Proc.Natl.Acad.Sci.USA, 120, 2023
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7DZ2
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![BU of 7dz2 by Molmil](/molmil-images/mine/7dz2) | Crystal structures of D-allulose 3-epimerase from Sinorhizobium fredii | 分子名称: | D-tagatose 3-epimerase, MAGNESIUM ION, SULFATE ION | 著者 | Zhu, Z.L, Miyakawa, T, Tanokura, M, Lu, F.P, Qin, H.-M. | 登録日 | 2021-01-23 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Substantial Improvement of an Epimerase for the Synthesis of D-Allulose by Biosensor-Based High-Throughput Microdroplet Screening Angew.Chem.Int.Ed.Engl., 2023
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7DZ3
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![BU of 7dz3 by Molmil](/molmil-images/mine/7dz3) | Crystal structures of D-allulose 3-epimerase with D-fructose from Sinorhizobium fredii | 分子名称: | D-fructose, D-tagatose 3-epimerase, MAGNESIUM ION | 著者 | Zhu, Z.L, Miyakawa, T, Tanokura, M, Lu, F.P, Qin, H.-M. | 登録日 | 2021-01-23 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Substantial Improvement of an Epimerase for the Synthesis of D-Allulose by Biosensor-Based High-Throughput Microdroplet Screening Angew.Chem.Int.Ed.Engl., 2023
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7DZ4
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![BU of 7dz4 by Molmil](/molmil-images/mine/7dz4) | Crystal structures of D-allulose 3-epimerase with D-tagatose from Sinorhizobium fredii | 分子名称: | D-tagatose, D-tagatose 3-epimerase, MAGNESIUM ION | 著者 | Zhu, Z.L, Miyakawa, T, Tanokura, M, Lu, F.P, Qin, H.-M. | 登録日 | 2021-01-23 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Substantial Improvement of an Epimerase for the Synthesis of D-Allulose by Biosensor-Based High-Throughput Microdroplet Screening Angew.Chem.Int.Ed.Engl., 2023
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7DZ6
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![BU of 7dz6 by Molmil](/molmil-images/mine/7dz6) | Crystal structures of D-allulose 3-epimerase with D-allulose from Sinorhizobium fredii | 分子名称: | D-psicose, D-tagatose 3-epimerase, MAGNESIUM ION | 著者 | Zhu, Z.L, Miyakawa, T, Tanokura, M, Lu, F.P, Qin, H.-M. | 登録日 | 2021-01-23 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Substantial Improvement of an Epimerase for the Synthesis of D-Allulose by Biosensor-Based High-Throughput Microdroplet Screening Angew.Chem.Int.Ed.Engl., 2023
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7DZ5
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![BU of 7dz5 by Molmil](/molmil-images/mine/7dz5) | Crystal structures of D-allulose 3-epimerase with D-sorbose from Sinorhizobium fredii | 分子名称: | D-sorbose, D-tagatose 3-epimerase, MAGNESIUM ION, ... | 著者 | Zhu, Z.L, Miyakawa, T, Tanokura, M, Lu, F.P, Qin, H.-M. | 登録日 | 2021-01-23 | 公開日 | 2022-08-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Substantial Improvement of an Epimerase for the Synthesis of D-Allulose by Biosensor-Based High-Throughput Microdroplet Screening Angew.Chem.Int.Ed.Engl., 2023
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5IKN
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4UEB
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4UE9
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4UEA
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4UEC
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4UED
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4UE8
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7DZ9
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![BU of 7dz9 by Molmil](/molmil-images/mine/7dz9) | MbnABC complex | 分子名称: | FE (III) ION, MbnA, MbnB, ... | 著者 | Chao, D, Dan, Z, Yijun, G, Wei, C. | 登録日 | 2021-01-25 | 公開日 | 2022-03-16 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res., 32, 2022
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7FC0
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![BU of 7fc0 by Molmil](/molmil-images/mine/7fc0) | Reconstitution of MbnABC complex from Rugamonas rubra ATCC-43154 (GroupIII) | 分子名称: | FE (III) ION, Methanobactin biosynthesis cassette protein MbnB, Methanobactin biosynthesis cassette protein MbnC, ... | 著者 | Chao, D, Zhaolin, L, Shoujie, L, Li, Z, Dan, Z, Ying, J, Wei, C. | 登録日 | 2021-07-13 | 公開日 | 2022-03-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.643 Å) | 主引用文献 | Crystal structure and catalytic mechanism of the MbnBC holoenzyme required for methanobactin biosynthesis. Cell Res., 32, 2022
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5W86
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4U81
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![BU of 4u81 by Molmil](/molmil-images/mine/4u81) | MEK1 Kinase bound to small molecule inhibitor G659 | 分子名称: | 8-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-7-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Robarge, K.D, Ultsch, M.H, Weismann, C. | 登録日 | 2014-07-31 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.701 Å) | 主引用文献 | Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
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4U80
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![BU of 4u80 by Molmil](/molmil-images/mine/4u80) | MEK 1 kinase bound to G799 | 分子名称: | 3-[(4-cyclopropyl-2-fluorophenyl)amino]-N-(2-hydroxyethoxy)furo[3,2-c]pyridine-2-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ... | 著者 | Ultsch, M.H, Robarge, K.D, Weismann, C. | 登録日 | 2014-07-31 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479. Bioorg.Med.Chem.Lett., 24, 2014
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7EFS
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