3T8M

Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform

Summary for 3T8M

• Entry DOI: 10.2210/pdb3t8m/pdb
• Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, N~2~-{2-chloro-4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-N~2~,N~8~-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide (3 entities in total)
• Functional Keywords: kinase p110, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P48736
• Total number of polymer chains: 1
• Total formula weight: 111280.17

Authors

Murray, J.M.,Wiesmann, C. (deposition date: 2011-08-01, release date: 2011-11-16, Last modification date: 2024-02-28)

• Primary citation: Heffron, T.,Wei, B.,Olivero, A.G.,Staben, S.T.,Tsui, V.,Do, S.,Dotson, J.,Folkes, A.,Goldsmith, A.,Goldsmith, R.,Gunzner, J.,Lesnick, J.,Lewis, C.,Mathieu, S.,Nonomiya, J.,Sutherlin, D.P.,Wan, N.C.,Wang, S.,Weismann, C.,Zhu, B.; Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)