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4PLB

Crystal Structure of S.A. gyrase-AM8191 complex

Summary for 4PLB
Entry DOI10.2210/pdb4plb/pdb
DescriptorDNA (5'-D(P*AP*GP*CP*CP*GP*TP*AP*GP*GP*GP*CP*CP*CP*TP*AP*CP*GP*GP*CP*T)-3'), Chimera protein of DNA gyrase subunits B and A, 6-[({(1r,4S)-1-[(1S)-2-(3-fluoro-6-methoxy-1,5-naphthyridin-4-yl)-1-hydroxyethyl]-2-oxabicyclo[2.2.2]oct-4-yl}amino)methyl]-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one, ... (6 entities in total)
Functional Keywordsgyase inhibitor complex, isomerase-isomerase inhibitor-dna complex, isomerase/isomerase inhibitor/dna
Biological sourceStaphylococcus aureus
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Cellular locationCytoplasm : P20831
Total number of polymer chains4
Total formula weight169329.35
Authors
Lu, J.,Patel, S.,Soisson, S. (deposition date: 2014-05-16, release date: 2014-06-18, Last modification date: 2023-12-27)
Primary citationSingh, S.B.,Kaelin, D.E.,Wu, J.,Miesel, L.,Tan, C.M.,Meinke, P.T.,Olsen, D.,Lagrutta, A.,Bradley, P.,Lu, J.,Patel, S.,Rickert, K.W.,Smith, R.F.,Soisson, S.,Wei, C.,Fukuda, H.,Kishii, R.,Takei, M.,Fukuda, Y.
Oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad spectrum antibacterial agents.
Acs Med.Chem.Lett., 5:609-614, 2014
Cited by
PubMed: 24900889
DOI: 10.1021/ml500069w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.69 Å)
Structure validation

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