2MQ0
 
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c | | 分子名称: | Myosin-binding protein C, cardiac-type | | 著者 | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | 登録日 | 2014-06-10 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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2NZO
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2NZH
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2MQ3
 | | NMR structure of the c3 domain of human cardiac myosin binding protein-c with a hypertrophic cardiomyopathy-related mutation R502W. | | 分子名称: | Myosin-binding protein C, cardiac-type | | 著者 | Zhang, X, De, S, Mcintosh, L.P, Paetzel, M. | | 登録日 | 2014-06-12 | | 公開日 | 2014-07-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Characterization of the C3 Domain of Cardiac Myosin Binding Protein C and Its Hypertrophic Cardiomyopathy-Related R502W Mutant.
Biochemistry, 53, 2014
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8SXR
 | | Crystal structure of SARS-CoV-2 Mpro with C5a | | 分子名称: | 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J. | | 登録日 | 2023-05-23 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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3U41
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1JHF
 | | LEXA G85D MUTANT | | 分子名称: | LEXA REPRESSOR, SULFATE ION | | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, Strynadka, N.C.J. | | 登録日 | 2001-06-27 | | 公開日 | 2001-09-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell(Cambridge,Mass.), 106, 2001
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1JHC
 | | LEXA S119A C-TERMINAL TRYPTIC FRAGMENT | | 分子名称: | LEXA REPRESSOR | | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, Strynadka, N.C.J. | | 登録日 | 2001-06-27 | | 公開日 | 2001-09-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell(Cambridge,Mass.), 106, 2001
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1JHH
 | | LEXA S119A MUTANT | | 分子名称: | LEXA REPRESSOR, SULFATE ION | | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, Strynadka, N.C.J. | | 登録日 | 2001-06-27 | | 公開日 | 2001-09-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell(Cambridge,Mass.), 106, 2001
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1JHE
 | | LEXA L89P Q92W E152A K156A MUTANT | | 分子名称: | LEXA REPRESSOR | | 著者 | Luo, Y, Pfuetzner, R.A, Mosimann, S, Little, J.W, J Strynadka, N.C. | | 登録日 | 2001-06-27 | | 公開日 | 2001-09-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of LexA: a conformational switch for regulation of self-cleavage.
Cell(Cambridge,Mass.), 106, 2001
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8CZ4
 | | Crystal structure of SARS-CoV-2 Mpro with compound C3 | | 分子名称: | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CYU
 | | Crystal structure of SARS-CoV-2 Mpro with compound C5 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CYZ
 | | Crystal structure of SARS-CoV-2 Mpro with compound C4 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-[4-(methylsulfanyl)phenyl]acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8CZ7
 | | Crystal structure of SARS-CoV-2 Mpro with compound C2 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
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8EXQ
 | | Cryo-EM structure of S. aureus BlaR1 with C1 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXP
 | | Cryo-EM structure of S. aureus BlaR1 with C2 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXR
 | | Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain | | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ... | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXS
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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8EXT
 | | Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2023-01-25 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
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