3UB0
 
 | | Crystal structure of the nonstructural protein 7 and 8 complex of Feline Coronavirus | | 分子名称: | Non-structural protein 6, nsp6,, Non-structural protein 7, ... | | 著者 | Xiao, Y, Hilgenfeld, R, Ma, Q. | | 登録日 | 2011-10-22 | | 公開日 | 2012-02-22 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Nonstructural proteins 7 and 8 of feline coronavirus form a 2:1 heterotrimer that exhibits primer-independent RNA polymerase activity.
J.Virol., 86, 2012
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2C1Y
 | | Structure of PDI-related Chaperone, Wind mutant-Y55K | | 分子名称: | WINDBEUTEL PROTEIN | | 著者 | Sevvana, M, Ma, Q, Barnewitz, K, Guo, C, Soling, H.-D, Ferrari, D.M, Sheldrick, G.M. | | 登録日 | 2005-09-22 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structural Elucidation of the Pdi-Related Chaperone Wind with the Help of Mutants.
Acta Crystallogr.,Sect.D, 62, 2006
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2C0G
 | | Structure of PDI-related Chaperone, Wind mutant-Y53S | | 分子名称: | CHLORIDE ION, SODIUM ION, WINDBEUTEL PROTEIN | | 著者 | Sevvana, M, Ma, Q, Barnewitz, K, Guo, C, Soling, H.-D, Ferrari, D.M, Sheldrick, G.M. | | 登録日 | 2005-09-02 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Elucidation of the Pdi-Related Chaperone Wind with the Help of Mutants.
Acta Crystallogr.,Sect.D, 62, 2006
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2C0F
 | | Structure of Wind Y53F mutant | | 分子名称: | WINDBEUTEL PROTEIN | | 著者 | Sevvana, M, Ma, Q, Barnewitz, K, Guo, C, Soling, H.-D, Ferrari, D.M, Sheldrick, G.M. | | 登録日 | 2005-09-02 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural Elucidation of the Pdi-Related Chaperone Wind with the Help of Mutants.
Acta Crystallogr.,Sect.D, 62, 2006
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2C0E
 | | Structure of PDI-related Chaperone, Wind with his-tag on C-terminus. | | 分子名称: | WINDBEUTEL PROTEIN | | 著者 | Sevvana, M, Ma, Q, Barnewitz, K, Guo, C, Soling, H.-D, Ferrari, D.M, Sheldrick, G.M. | | 登録日 | 2005-09-01 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural Elucidation of the Pdi-Related Chaperone Wind with the Help of Mutants.
Acta Crystallogr.,Sect.D, 62, 2006
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5N19
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5WXV
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4P16
 | | Crystal structure of the papain-like protease of Middle-East Respiratory Syndrome coronavirus | | 分子名称: | ORF1a, ZINC ION | | 著者 | Lei, J, Mesters, J.R, Ma, Q, Hilgenfeld, R. | | 登録日 | 2014-02-25 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features.
Antiviral Res., 109C, 2014
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8HKD
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8IGO
 | | Crystal structure of apo SARS-CoV-2 main protease | | 分子名称: | 3C-like proteinase nsp5 | | 著者 | Huang, X, Zhou, B, Xu, J, Yang, Z, Zhong, N, Xiong, X. | | 登録日 | 2023-02-21 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir.
Nat Microbiol, 9, 2024
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8IGN
 | | Crystal structure of SARS-CoV-2 main protease in complex with RAY1216 | | 分子名称: | (3~{S},3~{a}~{S},6~{a}~{R})-2-[(2~{S})-2-cyclohexyl-2-[2,2,2-tris(fluoranyl)ethanoylamino]ethanoyl]-~{N}-[(2~{S})-4-(cyclopentylamino)-3,4-bis(oxidanylidene)-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]butan-2-yl]-3,3~{a},4,5,6,6~{a}-hexahydro-1~{H}-cyclopenta[c]pyrrole-3-carboxamide, 3C-like proteinase nsp5 | | 著者 | Huang, X, Zhou, B, Xu, J, Yang, Z, Zhong, N, Xiong, X. | | 登録日 | 2023-02-21 | | 公開日 | 2023-04-05 | | 最終更新日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Preclinical evaluation of the SARS-CoV-2 M pro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir.
Nat Microbiol, 9, 2024
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8WOI
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8WOO
 | | Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state | | 分子名称: | ABC transporter B family member 19, Brassinolide, MAGNESIUM ION, ... | | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | | 登録日 | 2023-10-07 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
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8WP0
 | | Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state | | 分子名称: | ABC transporter B family member 19, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | | 登録日 | 2023-10-08 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
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8WOM
 | | Structure of the wild-type Arabidopsis ABCB19 in the brassinolide-bound state | | 分子名称: | ABC transporter B family member 19, Brassinolide | | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | | 登録日 | 2023-10-07 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
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5NH0
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5N5O
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5C3U
 | | Crystal structure of a fungal L-serine ammonia-lyase from Rhizomucor miehei | | 分子名称: | L-serine ammonia-lyase, PYRIDOXAL-5'-PHOSPHATE | | 著者 | Zhen, Q, Qiaojuan, Y, Shaoqing, Y, Zhengqiang, J. | | 登録日 | 2015-06-17 | | 公開日 | 2015-12-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Crystal structure and characterization of a novel l-serine ammonia-lyase from Rhizomucor miehei.
Biochem.Biophys.Res.Commun., 466, 2015
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6FV1
 | | Structure of human coronavirus NL63 main protease in complex with the alpha-ketoamide (S)-N-((S)-4-(benzylamino)-3,4-dioxo-1-((S)-2-oxopyrrolidin-3-yl)butan-2-yl)-2-cinnamamido-4-methylpentanamide (cinnamoyl-leucine-GlnLactam-CO-CO-NH-benzyl) | | 分子名称: | (2~{S})-4-methyl-~{N}-[(2~{S},3~{R})-3-oxidanyl-4-oxidanylidene-1-[(3~{S})-2-oxidanylidenepyrrolidin-3-yl]-4-[(phenylmethyl)amino]butan-2-yl]-2-[[(~{E})-3-phenylprop-2-enoyl]amino]pentanamide, 3C-like proteinase, DIMETHYL SULFOXIDE, ... | | 著者 | Zhang, L, Hilgenfeld, R. | | 登録日 | 2018-02-28 | | 公開日 | 2019-03-20 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication Structure-based design, synthesis, and activity assessment.
J.Med.Chem., 2020
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6FV2
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3FFN
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3FFK
 | | Crystal structure of human Gelsolin domains G1-G3 bound to Actin | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, actin, ... | | 著者 | Chumnarnsilpa, S, Robinson, R.C, Burtnick, L.D. | | 登録日 | 2008-12-03 | | 公開日 | 2009-10-06 | | 最終更新日 | 2017-11-01 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin.
Proc.Natl.Acad.Sci.USA, 106, 2009
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6J8R
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6J8Q
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6JN4
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