3FFK

Crystal structure of human Gelsolin domains G1-G3 bound to Actin

Summary for 3FFK

Entry DOI	10.2210/pdb3ffk/pdb
Related	1D0N 1H1V 1P8X 1P8Z 1RGI 2FGH 3FFK
Descriptor	plasma gelsolin, actin, alpha skeletal muscle, CALCIUM ION, ... (5 entities in total)
Functional Keywords	gelsolin, actin, ca-dependent, ca-activated, contractile protein, structural protein
Biological source	Homo sapiens (human) More
Cellular location	Isoform 2: Cytoplasm, cytoskeleton. Isoform 1: Secreted: P06396 Cytoplasm, cytoskeleton: P68135
Total number of polymer chains	4
Total formula weight	169483.26
Authors	Chumnarnsilpa, S.,Robinson, R.C.,Burtnick, L.D. (deposition date: 2008-12-03, release date: 2009-10-06, Last modification date: 2017-11-01)
Primary citation	Nag, S.,Ma, Q.,Wang, H.,Chumnarnsilpa, S.,Lee, W.L.,Larsson, M.,Kannan, B.,Hernandez-Valladares, M.,Burtnick, L.D.,Robinson, R.C. Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin. Proc.Natl.Acad.Sci.USA, 106:13713-13718, 2009 Cited by PubMed: 19666512 DOI: 10.1073/pnas.0812374106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation