4ZGP
| Structure of Cdc123 from Schizosaccharomyces pombe | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division cycle protein 123 | 著者 | Panvert, M, Dubiez, E, Arnold, L, Perez, J, Seufert, W, Mechulam, Y, Schmitt, E. | 登録日 | 2015-04-23 | 公開日 | 2015-10-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Cdc123, a Cell Cycle Regulator Needed for eIF2 Assembly, Is an ATP-Grasp Protein with Unique Features. Structure, 23, 2015
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4BW1
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | 登録日 | 2013-06-29 | 公開日 | 2013-09-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
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4BW3
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | 分子名称: | 1,2-ETHANEDIOL, 4-((2-(tert-butyl)phenyl)amino)-7-(3,5-dimethylisoxazol-4-yl)-6-methoxy-1,5-naphthyridine-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | 登録日 | 2013-06-29 | 公開日 | 2013-09-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
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4BW2
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | 分子名称: | 1,2-ETHANEDIOL, 4-((2-(TERT-BUTYL)PHENYL)AMINO)-7-(3,5-dimethylisoxazol-4-yl)-1,8-naphthyridine-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | 登録日 | 2013-06-29 | 公開日 | 2013-09-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
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2MS9
| Solution structure of a G-quadruplex | 分子名称: | DNA (28-MER) | 著者 | Chung, W.J, Heddi, B, Schmitt, E, Lim, K.W, Mechulam, Y, Phan, A.T. | 登録日 | 2014-07-25 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure of a left-handed DNA G-quadruplex Proc.Natl.Acad.Sci.USA, 2015
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4BW4
| The first bromodomain of human BRD4 in complex with 3,5 dimethylisoxaxole ligand | 分子名称: | 7-(3,5-dimethylisoxazol-4-yl)-8-methoxy-1-(2-(trifluoromethoxy)phenyl)-1h-imidazo[4,5-c][1,5]naphthyridin-2(3h)-one, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Mirguet, O, Lamotte, Y, Bamborough, P, Delannee, D, Bouillot, A, Gellibert, F, Krysa, G, Lewis, A, Witherington, J, Huet, P, Dudit, Y, Trottet, L, Nicodeme, E. | 登録日 | 2013-06-29 | 公開日 | 2013-09-11 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Naphthyridines as Novel Bet Family Bromodomain Inhibitors. Chemmedchem, 9, 2014
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8BRW
| Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C | 分子名称: | Methionine--tRNA ligase, ZINC ION | 著者 | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | 登録日 | 2022-11-24 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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8BRX
| Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C complexed with beta-3-methionine | 分子名称: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | 著者 | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | 登録日 | 2022-11-24 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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8BRV
| Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C complexed with beta3-methionine. | 分子名称: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | 著者 | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | 登録日 | 2022-11-24 | 公開日 | 2023-08-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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8BRU
| Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C | 分子名称: | CITRIC ACID, Methionine--tRNA ligase, ZINC ION | 著者 | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | 登録日 | 2022-11-24 | 公開日 | 2023-08-16 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments. Protein Sci., 32, 2023
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1XTY
| Crystal structure of Sulfolobus solfataricus peptidyl-tRNA hydrolase | 分子名称: | Peptidyl-tRNA hydrolase, SULFATE ION | 著者 | Fromant, M, Schmitt, E, Mechulam, Y, Lazennec, C, Plateau, P, Blanquet, S. | 登録日 | 2004-10-25 | 公開日 | 2005-03-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crystal structure at 1.8 A resolution and identification of active site residues of Sulfolobus solfataricus peptidyl-tRNA hydrolase. Biochemistry, 44, 2005
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3CW6
| E. coli Initiator tRNA | 分子名称: | Initiator tRNA | 著者 | Barraud, P, Schmitt, E, Mechulam, Y, Dardel, F, Tisne, C. | 登録日 | 2008-04-21 | 公開日 | 2008-09-02 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | A unique conformation of the anticodon stem-loop is associated with the capacity of tRNAfMet to initiate protein synthesis. Nucleic Acids Res., 36, 2008
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3CW5
| E. coli Initiator tRNA | 分子名称: | Initiator tRNA | 著者 | Barraud, P, Schmitt, E, Mechulam, Y, Dardel, F, Tisne, C. | 登録日 | 2008-04-21 | 公開日 | 2008-09-02 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A unique conformation of the anticodon stem-loop is associated with the capacity of tRNAfMet to initiate protein synthesis. Nucleic Acids Res., 36, 2008
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7DFY
| Novel motif for left-handed G-quadruplex formation | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2xMotif2, POTASSIUM ION, ... | 著者 | Das, P, Winnerdy, F.R, Maity, A, Mechulam, Y, Phan, A.T. | 登録日 | 2020-11-10 | 公開日 | 2021-09-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | A novel minimal motif for left-handed G-quadruplex formation. Chem.Commun.(Camb.), 57, 2021
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2FMT
| METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET | 分子名称: | FORMYL-METHIONYL-TRNAFMET2, MAGNESIUM ION, METHIONYL-TRNA FMET FORMYLTRANSFERASE, ... | 著者 | Schmitt, E, Mechulam, Y, Blanquet, S. | 登録日 | 1998-07-29 | 公開日 | 1999-07-29 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet. EMBO J., 17, 1998
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7D5F
| Left-handed G-quadruplex containing 3 bulges | 分子名称: | 3xBulge-LHG4motif | 著者 | Winnerdy, F.R, Das, P, Ngo, K.H, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | 登録日 | 2020-09-25 | 公開日 | 2021-02-10 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
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7D5D
| Left-handed G-quadruplex containing one bulge | 分子名称: | 1xBulge-LHG4motif, POTASSIUM ION, SPERMINE | 著者 | Das, P, Ngo, K.H, Winnerdy, F.R, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | 登録日 | 2020-09-25 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
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7D5E
| Left-handed G-quadruplex containing two bulges | 分子名称: | 2xBulge-LHG4motif, POTASSIUM ION, SODIUM ION, ... | 著者 | Das, P, Maity, A, Ngo, K.H, Winnerdy, F.R, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | 登録日 | 2020-09-25 | 公開日 | 2021-02-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.296 Å) | 主引用文献 | Bulges in left-handed G-quadruplexes. Nucleic Acids Res., 49, 2021
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4AKN
| N-Terminal Bromodomain of Human BRD2 With tbutyl-phenyl-amino- dimethyl-oxazolyl-quinoline-carboxylic acid | 分子名称: | 1,2-ETHANEDIOL, 4-[(2-tert-butylphenyl)amino]-7-(3,5-dimethyl-1,2-oxazol-4-yl)quinoline-3-carboxylic acid, BROMODOMAIN-CONTAINING PROTEIN 2, ... | 著者 | Chung, C, Lamotte, Y, Donche, F, Bouillot, A, Mirguet, O. | 登録日 | 2012-02-26 | 公開日 | 2012-07-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22, 2012
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4ALG
| N-Terminal Bromodomain of Human BRD2 With IBET-151 | 分子名称: | 7-(3,5-DIMETHYL-1,2-OXAZOL-4-YL)-8-METHOXY-1-[(1R)-1-(PYRIDIN-2-YL)ETHYL]-1H,2H,3H-IMIDAZO[4,5-C]QUINOLIN-2-ONE, ACETATE ION, BROMODOMAIN-CONTAINING PROTEIN 2, ... | 著者 | Chung, C, Lamotte, Y, Donche, F, Bouillot, A, Mirguet, O. | 登録日 | 2012-03-03 | 公開日 | 2012-07-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Identification of a Novel Series of Bet Family Bromodomain Inhibitors: Binding Mode and Profile of I-Bet151 (Gsk1210151A). Bioorg.Med.Chem.Lett., 22, 2012
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6GZ6
| Structure of a left-handed G-quadruplex | 分子名称: | DNA (27-MER), POTASSIUM ION | 著者 | Bakalar, B, Heddi, B, Schmitt, E, Mechulam, Y, Phan, A.T. | 登録日 | 2018-07-03 | 公開日 | 2019-04-24 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.006 Å) | 主引用文献 | A Minimal Sequence for Left-Handed G-Quadruplex Formation. Angew.Chem.Int.Ed.Engl., 58, 2019
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6SPO
| Structure of the Escherichia coli methionyl-tRNA synthetase complexed with methionine | 分子名称: | CITRIC ACID, GLYCEROL, METHIONINE, ... | 著者 | Nigro, G, Schmitt, E, Mechulam, Y. | 登録日 | 2019-09-02 | 公開日 | 2020-01-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J.Struct.Biol., 209, 2020
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1MKH
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6SPQ
| Structure of the Escherichia coli methionyl-tRNA synthetase variant VI298 complexed with methionine | 分子名称: | CITRIC ACID, GLYCEROL, METHIONINE, ... | 著者 | Nigro, G, Schmitt, E, Mechulam, Y. | 登録日 | 2019-09-02 | 公開日 | 2020-01-01 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Use of beta3-methionine as an amino acid substrate of Escherichia coli methionyl-tRNA synthetase. J.Struct.Biol., 209, 2020
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6SW9
| IC2A model of cryo-EM structure of a full archaeal ribosomal translation initiation complex devoid of aIF1 in P. abyssi | 分子名称: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | 著者 | Coureux, P.-D, Mechulam, Y, Schmitt, E. | 登録日 | 2019-09-20 | 公開日 | 2020-02-19 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Cryo-EM study of an archaeal 30S initiation complex gives insights into evolution of translation initiation. Commun Biol, 3, 2020
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