6WW4
 
 | | Crystal structure of HERC2 ZZ domain in complex with histone H3 tail | | 分子名称: | GLYCEROL, Histone H3.1,E3 ubiquitin-protein ligase HERC2, ZINC ION | | 著者 | Liu, J, Vann, K.R, Kutateladze, T.G. | | 登録日 | 2020-05-07 | | 公開日 | 2020-08-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | | 主引用文献 | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
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6WW3
 | | Crystal structure of HERC2 ZZ domain in complex with SUMO1 tail | | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, SUMO1 linked HERC2 ZZ domain (Small ubiquitin-related modifier 1,E3 ubiquitin-protein ligase HERC2), ... | | 著者 | Liu, J, Vann, K.R, Kutateladze, T.G. | | 登録日 | 2020-05-07 | | 公開日 | 2020-08-05 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.096 Å) | | 主引用文献 | Structural Insight into Binding of the ZZ Domain of HERC2 to Histone H3 and SUMO1.
Structure, 28, 2020
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6WW8
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2GP5
 | | Crystal structure of catalytic core domain of jmjd2A complexed with alpha-Ketoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, FE (II) ION, Jumonji domain-containing protein 2A, ... | | 著者 | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | | 登録日 | 2006-04-16 | | 公開日 | 2006-05-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structural insights into histone demethylation by JMJD2 family members
Cell(Cambridge,Mass.), 125, 2006
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2GP3
 | | Crystal structure of the catalytic core domain of jmjd2a | | 分子名称: | FE (II) ION, Jumonji domain-containing protein 2A, ZINC ION | | 著者 | Chen, Z, Zang, J, Whetstine, J, Hong, X, Davrazou, F, Kutateladze, T.G, Simpson, M, Dai, S, Hagman, J, Shi, Y, Zhang, G. | | 登録日 | 2006-04-16 | | 公開日 | 2006-05-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural insights into histone demethylation by JMJD2 family members
Cell(Cambridge,Mass.), 125, 2006
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5TDR
 | | Set3 PHD finger in complex with histone H3K4me2 | | 分子名称: | Histone H3, SET domain-containing protein 3, SODIUM ION, ... | | 著者 | Andrews, F.H, Ali, M, Kutateladze, T.G. | | 登録日 | 2016-09-19 | | 公開日 | 2016-11-02 | | 最終更新日 | 2017-06-28 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Structural Insight into Recognition of Methylated Histone H3K4 by Set3.
J. Mol. Biol., 429, 2017
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5U28
 | | BRD4 first bromodomain (BD1) in complex with dual PI3 kinase inhibitor SF2523 | | 分子名称: | 3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-(morpholin-4-yl)-7H-thieno[3,2-b]pyran-7-one, Bromodomain-containing protein 4, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Andrews, F.H, Kutateladze, T.G. | | 登録日 | 2016-11-30 | | 公開日 | 2017-02-08 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (1.798 Å) | | 主引用文献 | Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5U2C
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5U2J
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5U2E
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5WLE
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5WLF
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5U2F
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6MIU
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6MJ7
 | | Crystal structure of p62 ZZ domain in complex with free arginine | | 分子名称: | 1,4-DIETHYLENE DIOXIDE, ARGININE, Sequestosome-1, ... | | 著者 | Ahn, J, Zhang, Y, Kutateladze, T.G. | | 登録日 | 2018-09-20 | | 公開日 | 2018-10-31 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.412 Å) | | 主引用文献 | ZZ-dependent regulation of p62/SQSTM1 in autophagy.
Nat Commun, 9, 2018
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6O1E
 | | The crystal structure of human MORC3 ATPase-CW in complex with AMPPNP | | 分子名称: | MAGNESIUM ION, MORC family CW-type zinc finger protein 3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Klein, B.J, Zhang, Y, Kutateladze, T.G. | | 登録日 | 2019-02-19 | | 公開日 | 2019-03-20 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Mechanism for autoinhibition and activation of the MORC3 ATPase.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6O7G
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8F5Q
 | | Crystal structure of human PCNA in complex with the PIP box of FBH1 | | 分子名称: | F-box DNA helicase 1, Proliferating cell nuclear antigen | | 著者 | Liu, J, Chaves-Arquero, B, Wei, P, Tencer, H, Zhang, G, Blanco, F, Kutateladze, T. | | 登録日 | 2022-11-15 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Molecular insight into the PCNA-binding mode of FBH1.
Structure, 31, 2023
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5IOK
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5XNV
 | | Crystal structure of YEATS2 YEATS bound to H3K27ac peptide | | 分子名称: | ALA-ALA-ARG-ALY-SER-ALA-PRO-ALA, AMMONIUM ION, CHLORIDE ION, ... | | 著者 | Li, H.T, Guan, H.P, Zhao, D. | | 登録日 | 2017-05-24 | | 公開日 | 2017-11-01 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.696 Å) | | 主引用文献 | YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer.
Nat Commun, 8, 2017
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3OQ5
 | | Crystal structure of the 3-MBT domain from human L3MBTL1 in complex with p53K382me1 | | 分子名称: | Cellular tumor antigen p53, Lethal(3)malignant brain tumor-like protein | | 著者 | Roy, S, West, L.E, Weiner, K.L, Hayashi, R, Shi, X, Appella, E, Gozani, O, Kutateladze, T. | | 登録日 | 2010-09-02 | | 公開日 | 2010-09-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.5005 Å) | | 主引用文献 | The MBT Repeats of L3MBTL1 Link SET8-mediated p53 Methylation at Lysine 382 to Target Gene Repression.
J.Biol.Chem., 285, 2010
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6WXK
 | | PHF23 PHD Domain Apo | | 分子名称: | PHD finger protein 23, ZINC ION | | 著者 | Vann, K.R, Zhang, J, Zhang, Y, Kutateladze, T. | | 登録日 | 2020-05-11 | | 公開日 | 2020-07-15 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Mechanistic insights into chromatin targeting by leukemic NUP98-PHF23 fusion.
Nat Commun, 11, 2020
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7R1O
 | | p62-ZZ domain of the human sequestosome in complex with dusquetide | | 分子名称: | Dusquetide, Sequestosome-1, ZINC ION | | 著者 | Hakansson, M, Hansson, M, Logan, D.T, Rozek, A, Donini, O. | | 登録日 | 2022-02-03 | | 公開日 | 2022-05-18 | | 最終更新日 | 2022-08-17 | | 実験手法 | X-RAY DIFFRACTION (2.202 Å) | | 主引用文献 | Dusquetide modulates innate immune response through binding to p62.
Structure, 30, 2022
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2L5U
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2MWO
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