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8Q40
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BU of 8q40 by Molmil
Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate
分子名称: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*CP*A)-3'), DUF1887 family protein, ...
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q41
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BU of 8q41 by Molmil
Crystal structure of Can2 (E341A) bound to cA4 and TTTAAA ssDNA
分子名称: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*AP*AP*A)-3'), DUF1887 family protein, ...
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q42
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BU of 8q42 by Molmil
Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA
分子名称: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*AP*AP*AP*A)-3'), DUF1887 family protein, ...
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q43
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BU of 8q43 by Molmil
Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-C DNA
分子名称: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*CP*CP*CP*CP*C)-3'), DUF1887 family protein, ...
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q44
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BU of 8q44 by Molmil
Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA
分子名称: Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*T)-3'), DUF1887 family protein, ...
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q3Z
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BU of 8q3z by Molmil
Crystal structure of cA4-bound Can2 from Thermoanaerobacter brockii
分子名称: Cyclic tetraadenosine monophosphate (cA4), DUF1887 family protein, MANGANESE (II) ION
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
8Q3Y
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BU of 8q3y by Molmil
Crystal structure of apo Can2 from Thermoanaerobacter brockii
分子名称: DUF1887 family protein
著者Jungfer, K, Sigg, A, Jinek, M.
登録日2023-08-04
公開日2023-11-22
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2.
Nucleic Acids Res., 52, 2024
7Z4E
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BU of 7z4e by Molmil
SpCas9 bound to 8-nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 8 nucleotide complementary DNA substrate, Target strand of 8 nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (4.14 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4I
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BU of 7z4i by Molmil
SpCas9 bound to 16-nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 16-nucleotide complementary DNA substrate, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.12 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4C
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BU of 7z4c by Molmil
SpCas9 bound to 6 nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 6 nucleotide complementary DNA substrate, Target strand of 6 nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.87 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4H
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BU of 7z4h by Molmil
SpCas9 bound to 14-nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 14-nucleotide complementary DNA substrate, Target strand of 14-nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4G
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BU of 7z4g by Molmil
SpCas9 bound to 12-nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 12-nucleotide complementary DNA substrate, Target strand of 12-nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.64 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4K
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BU of 7z4k by Molmil
SpCas9 bound to 10-nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10-nucleotide complementary DNA substrate, Target strand of 10-nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-04
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (3.81 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4J
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BU of 7z4j by Molmil
SpCas9 bound to 18-nucleotide complementary DNA substrate in the catalytic state
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, Non-target strand of 18-nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.99 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4L
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BU of 7z4l by Molmil
SpCas9 bound to 18-nucleotide complementary DNA substrate in the checkpoint state
分子名称: CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, Non-target strand of 18-nucleotide complementary DNA substrate, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-04
公開日2022-08-31
最終更新日2024-07-17
実験手法ELECTRON MICROSCOPY (2.54 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7Z4D
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BU of 7z4d by Molmil
Crystal structure of SpCas9 bound to a 10 nucleotide complementary DNA substrate
分子名称: CRISPR-associated endonuclease Cas9/Csn1, Non-target strand of 10 nucleotide complementary DNA substrate, POTASSIUM ION, ...
著者Pacesa, M, Jinek, M.
登録日2022-03-03
公開日2022-08-31
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献R-loop formation and conformational activation mechanisms of Cas9.
Nature, 609, 2022
7ZYH
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BU of 7zyh by Molmil
Crystal structure of human CPSF30 in complex with hFip1
分子名称: Cleavage and polyadenylation specificity factor subunit 4, Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1, ZINC ION
著者Muckenfuss, L.M, Jinek, M, Migenda Herranz, A.C, Clerici, M.
登録日2022-05-24
公開日2022-09-14
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
7ZO1
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BU of 7zo1 by Molmil
SpCas9 bound to CD34 off-target9 DNA substrate
分子名称: CD34 off-target9 DNA non-target strand, CD34 off-target9 DNA target strand, CD34 sgRNA, ...
著者Pacesa, M, Jinek, M.
登録日2022-04-23
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022
5FW2
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BU of 5fw2 by Molmil
Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-06-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.676 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5FW3
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BU of 5fw3 by Molmil
Crystal structure of SpCas9 variant VRER bound to sgRNA and TGCG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-06-15
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
5FSH
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BU of 5fsh by Molmil
Crystal structure of Thermus thermophilus Csm6
分子名称: CSM6, NICKEL (II) ION
著者Niewoehner, O, Jinek, M.
登録日2016-01-06
公開日2016-01-27
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Structural Basis for the Endoribonuclease Activity of the Type III-A Crispr-Associated Protein Csm6.
RNA, 22, 2016
7ZY4
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BU of 7zy4 by Molmil
Crystal structure of human CstF77 in complex with hFip1
分子名称: Cleavage stimulation factor subunit 3, GLYCEROL, hFip1
著者Muckenfuss, L.M, Jinek, M.
登録日2022-05-23
公開日2022-09-14
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
Elife, 11, 2022
5FW1
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BU of 5fw1 by Molmil
Crystal structure of SpyCas9 variant VQR bound to sgRNA and TGAG PAM target DNA
分子名称: CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ...
著者Anders, C, Bargsten, K, Jinek, M.
登録日2016-02-11
公開日2016-04-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9.
Mol.Cell, 61, 2016
6F9W
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BU of 6f9w by Molmil
Crystal structure of the LSM domain of LSM14 in complex with a C-terminal peptide of 4E-T
分子名称: Eukaryotic translation initiation factor 4E transporter, Protein LSM14 homolog A
著者Brandmann, T, Jinek, M.
登録日2017-12-15
公開日2018-03-21
最終更新日2018-04-11
実験手法X-RAY DIFFRACTION (2.623 Å)
主引用文献Molecular architecture of LSM14 interactions involved in the assembly of mRNA silencing complexes.
EMBO J., 37, 2018
7QQR
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BU of 7qqr by Molmil
SpCas9 bound to AAVS1 off-target5 DNA substrate
分子名称: 1,2-ETHANEDIOL, AAVS1 off-target5 non-target strand, AAVS1 off-target5 target strand, ...
著者Pacesa, M, Jinek, M.
登録日2022-01-10
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural basis for Cas9 off-target activity.
Cell, 185, 2022

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件を2024-10-09に公開中

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