5NFV
| Crystal structure of catalytically inactive FnCas12 mutant bound to an R-loop structure containing a pre-crRNA mimic and full-length DNA target | 分子名称: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CRISPR-associated endonuclease Cpf1, DNA non-target strand, ... | 著者 | Swarts, D.C, van der Oost, J, Jinek, M. | 登録日 | 2017-03-16 | 公開日 | 2017-06-14 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Structural Basis for Guide RNA Processing and Seed-Dependent DNA Targeting by CRISPR-Cas12a. Mol. Cell, 66, 2017
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5NG6
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6FUW
| Cryo-EM structure of the human CPSF160-WDR33-CPSF30 complex bound to the PAS AAUAAA motif at 3.1 Angstrom resolution | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, Cleavage and polyadenylation specificity factor subunit 4, RNA (5'-R(P*AP*AP*UP*AP*AP*AP*GP*G)-3'), ... | 著者 | Clerici, M, Faini, M, Jinek, M. | 登録日 | 2018-02-28 | 公開日 | 2018-03-21 | 最終更新日 | 2023-02-22 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Structural basis of AAUAAA polyadenylation signal recognition by the human CPSF complex. Nat. Struct. Mol. Biol., 25, 2018
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5FW2
| Crystal structure of SpCas9 variant EQR bound to sgRNA and TGAG PAM target DNA | 分子名称: | CRISPR-ASSOCIATED ENDONUCLEASE CAS9/CSN1, MAGNESIUM ION, NON-TARGET DNA STRAND, ... | 著者 | Anders, C, Bargsten, K, Jinek, M. | 登録日 | 2016-02-11 | 公開日 | 2016-06-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.676 Å) | 主引用文献 | Structural Plasticity of Pam Recognition by Engineered Variants of the RNA-Guided Endonuclease Cas9. Mol.Cell, 61, 2016
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6F9N
| CRYSTAL STRUCTURE OF THE HUMAN CPSF160-WDR33 COMPLEX | 分子名称: | Cleavage and polyadenylation specificity factor subunit 1, pre-mRNA 3' end processing protein WDR33 | 著者 | Clerici, M, Jinek, M. | 登録日 | 2017-12-14 | 公開日 | 2018-01-03 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex. Elife, 6, 2017
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7PLA
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7OXD
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7P3B
| Human RNA ligase RTCB in complex with GMP and Co(II) | 分子名称: | ACETATE ION, COBALT (II) ION, FORMIC ACID, ... | 著者 | Kroupova, A, Ackle, F, Jinek, M. | 登録日 | 2021-07-07 | 公開日 | 2021-12-22 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular architecture of the human tRNA ligase complex. Elife, 10, 2021
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7P3A
| N-terminal domain of CGI-99 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2021-07-07 | 公開日 | 2021-12-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Molecular architecture of the human tRNA ligase complex. Elife, 10, 2021
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7PLH
| Scytonema hofmannii TnsC bound to AMPPNP and DNA | 分子名称: | DNA (5'-D(P*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Querques, I, Jinek, M. | 登録日 | 2021-08-31 | 公開日 | 2021-12-01 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | Target site selection and remodelling by type V CRISPR-transposon systems. Nature, 599, 2021
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8Q42
| Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-A DNA | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*AP*AP*AP*A)-3'), DUF1887 family protein, ... | 著者 | Jungfer, K, Sigg, A, Jinek, M. | 登録日 | 2023-08-04 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q44
| Crystal structure of cA4-bound Can2 (E364R) in complex with oligo-T DNA | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*T)-3'), DUF1887 family protein, ... | 著者 | Jungfer, K, Sigg, A, Jinek, M. | 登録日 | 2023-08-04 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q3Y
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8Q40
| Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*CP*A)-3'), DUF1887 family protein, ... | 著者 | Jungfer, K, Sigg, A, Jinek, M. | 登録日 | 2023-08-04 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q41
| Crystal structure of Can2 (E341A) bound to cA4 and TTTAAA ssDNA | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*TP*TP*AP*AP*A)-3'), DUF1887 family protein, ... | 著者 | Jungfer, K, Sigg, A, Jinek, M. | 登録日 | 2023-08-04 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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8Q3Z
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8Q43
| Crystal structure of cA4-bound Can2 (E341A) in complex with oligo-C DNA | 分子名称: | Cyclic tetraadenosine monophosphate (cA4), DNA (5'-D(*CP*CP*CP*CP*C)-3'), DUF1887 family protein, ... | 著者 | Jungfer, K, Sigg, A, Jinek, M. | 登録日 | 2023-08-04 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52, 2024
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3ICQ
| Karyopherin nuclear state | 分子名称: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | 登録日 | 2009-07-18 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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3IBV
| Karyopherin cytosolic state | 分子名称: | CALCIUM ION, Exportin-T | 著者 | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | 登録日 | 2009-07-17 | 公開日 | 2009-08-25 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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6RW0
| Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase | 分子名称: | GLYCEROL, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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6TUG
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6RVZ
| Crystal structure of ANGEL2, a 2',3'-cyclic phosphatase, in complex with adenosine-2',3'-vanadate | 分子名称: | ADENOSINE, MAGNESIUM ION, POTASSIUM ION, ... | 著者 | Kroupova, A, Jinek, M. | 登録日 | 2019-06-03 | 公開日 | 2020-05-20 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | ANGEL2 is a member of the CCR4 family of deadenylases with 2',3'-cyclic phosphatase activity. Science, 369, 2020
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7QQQ
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7QQV
| SpCas9 bound to FANCF off-target3 DNA substrate | 分子名称: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target3 non-target strand, FANCF off-target3 target strand, ... | 著者 | Pacesa, M, Jinek, M. | 登録日 | 2022-01-10 | 公開日 | 2022-10-26 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR8
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