6YLZ
| X-ray structure of the K72I,Y129F,R133L, H199A quadruple mutant of PNP-oxidase from E. coli | 分子名称: | FLAVIN MONONUCLEOTIDE, PHOSPHATE ION, Pyridoxine/pyridoxamine 5'-phosphate oxidase, ... | 著者 | Battista, T, Sularea, M, Barile, A, Fiorillo, A, Tramonti, A, Ilari, A. | 登録日 | 2020-04-07 | 公開日 | 2021-04-14 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.558 Å) | 主引用文献 | Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase. J.Biol.Chem., 296, 2021
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6YMH
| X-ray structure of the K72I, Y129F, R133L, H199A quadruple mutant of PNP-oxidase from E. coli in complex with PLP | 分子名称: | FLAVIN MONONUCLEOTIDE, PYRIDOXAL-5'-PHOSPHATE, Pyridoxine/pyridoxamine 5'-phosphate oxidase, ... | 著者 | Battista, T, Sularea, M, Barile, A, Fiorillo, A, Tramonti, A, Ilari, A. | 登録日 | 2020-04-08 | 公開日 | 2021-04-28 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.417 Å) | 主引用文献 | Identification and characterization of the pyridoxal 5'-phosphate allosteric site in Escherichia coli pyridoxine 5'-phosphate oxidase. J.Biol.Chem., 296, 2021
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8PF3
| Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 1-(3,4-dichlorobenzyl)-4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-(3-phenylpropyl)piperazin-1-ium | 分子名称: | 4-[(3,4-dichlorophenyl)methyl]-~{N}-(4-fluorophenyl)-~{N}-[[5-[2-(4-fluorophenyl)ethylcarbamoyl]furan-2-yl]methyl]-4-(3-phenylpropyl)-1,4$l^{4}-diazinane-1-carboxamide, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Exertier, C, Ilari, A, Fiorillo, A, Antonelli, L. | 登録日 | 2023-06-15 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J.Med.Chem., 67, 2024
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8PF4
| Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)(4-fluorophenyl)carbamoyl)-1-methyl-1-(3-phenylpropyl)piperazin-1-ium | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Exertier, C, Ilari, A, Fiorillo, A, Antonelli, L. | 登録日 | 2023-06-15 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J.Med.Chem., 67, 2024
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8PF5
| Crystal structure of Trypanosoma brucei trypanothione reductase in complex with 1-(3,4-dichlorobenzyl)-4-(((5-((4-fluorophenethyl)carbamoyl)furan-2-yl)methyl)carbamoyl)-1-(3-phenylpropyl)piperazin-1-ium | 分子名称: | 4-[(3,4-dichlorophenyl)methyl]-~{N}-[[5-[2-(4-fluorophenyl)ethylcarbamoyl]furan-2-yl]methyl]-4-(3-phenylpropyl)-1,4$l^{4}-diazinane-1-carboxamide, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | 著者 | Exertier, C, Antonelli, L, Fiorillo, A, Ilari, A. | 登録日 | 2023-06-15 | 公開日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Fragment Merging, Growing, and Linking Identify New Trypanothione Reductase Inhibitors for Leishmaniasis. J.Med.Chem., 67, 2024
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2JC2
| The crystal structure of the natural F112L human sorcin mutant | 分子名称: | SORCIN, SULFATE ION | 著者 | Franceschini, S, Ilari, A, Colotti, G, Chiancone, E. | 登録日 | 2006-12-19 | 公開日 | 2007-08-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular Basis for the Impaired Function of the Natural F112L Sorcin Mutant: X-Ray Crystal Structure, Calcium Affinity, and Interaction with Annexin Vii and the Ryanodine Receptor. Faseb J., 22, 2008
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3S9F
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3TUE
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4UQV
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7AHW
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7ALY
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7AMX
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3G8M
| Serine Hydroxymethyltransferase Y55F Mutant | 分子名称: | PYRIDOXAL-5'-PHOSPHATE, Serine hydroxymethyltransferase | 著者 | Angelucci, F, Ilari, A. | 登録日 | 2009-02-12 | 公開日 | 2009-11-10 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Role of a conserved active site cation-pi interaction in Escherichia coli serine hydroxymethyltransferase. Biochemistry, 48, 2009
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4ADW
| CRYSTAL STRUCTURE OF LEISHMANIA INFANTUM TRYPANOTHIONE REDUCTASE IN COMPLEX WITH NADPH AND TRYPANOTHIONE | 分子名称: | BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Baiocco, P, Ilari, A, Colotti, G, Malatesta, F, Fiorillo, A. | 登録日 | 2012-01-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.61 Å) | 主引用文献 | Inhibition of Leishmania Infantum Trypanothione Reductase by Azole-Based Compounds: A Comparative Analysis with its Physiological Substrate by X-Ray Crystallography. Chemmedchem, 8, 2013
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4APN
| Structure of TR from Leishmania infantum in complex with a diarylpirrole-based inhibitor | 分子名称: | 4-[[1-(4-ethylphenyl)-2-methyl-5-(4-methylsulfanylphenyl)pyrrol-3-yl]methyl]thiomorpholine, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Baiocco, P, Ilari, A, Colotti, G, Biava, M. | 登録日 | 2012-04-04 | 公開日 | 2013-04-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Inhibition of Leishmania Infantum Trypanothione Reductase by Azole-Based Compounds: A Comparative Analysis with its Physiological Substrate by X-Ray Crystallography. Chemmedchem, 8, 2013
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5BY9
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2JK6
| Structure of Trypanothione Reductase from Leishmania infantum | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TRYPANOTHIONE REDUCTASE | 著者 | Baiocco, P, Colotti, G, Franceschini, S, Ilari, A. | 登録日 | 2008-08-21 | 公開日 | 2009-04-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Molecular Basis of Antimony Treatment in Leishmaniasis. J.Med.Chem., 52, 2009
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5M5J
| Thioredoxin reductase from Giardia duodenalis | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, SODIUM ION, Thioredoxin reductase | 著者 | Fiorillo, A, Ilari, A, Lalle, M. | 登録日 | 2016-10-21 | 公開日 | 2017-05-17 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Structural characterization of Giardia duodenalis thioredoxin reductase (gTrxR) and computational analysis of its interaction with NBDHEX. Eur J Med Chem, 135, 2017
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5SMJ
| Trypanothione reductase | 分子名称: | BROMIDE ION, DIMETHYL SULFOXIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Fiorillo, A, Ilari, A. | 登録日 | 2022-03-05 | 公開日 | 2023-03-01 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Innovative Approach for a Classic Target: Fragment Screening on Trypanothione Reductase Reveals New Opportunities for Drug Design. Front Mol Biosci, 9, 2022
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4BHD
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2VXX
| X-ray structure of DpsA from Thermosynechococcus elongatus | 分子名称: | DI(HYDROXYETHYL)ETHER, FE (III) ION, STARVATION INDUCED DNA BINDING PROTEIN, ... | 著者 | Franceschini, S, Ilari, A. | 登録日 | 2008-07-14 | 公開日 | 2009-11-17 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Thermosynechococcus Elongatus Dpsa Binds Zn(II) at a Unique Three Histidine-Containing Ferroxidase Center and Utilizes O2 as Iron Oxidant with Very High Efficiency, Unlike the Typical Dps Proteins. FEBS J., 277, 2010
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2W0H
| X ray structure of Leishmania infantum Trypanothione reductase in complex with antimony and NADPH | 分子名称: | ANTIMONY (III) ION, FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Baiocco, P, Colotti, G, Franceschini, S, Ilari, A. | 登録日 | 2008-08-18 | 公開日 | 2009-04-28 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Molecular Basis of Antimony Treatment in Leishmaniasis. J.Med.Chem., 52, 2009
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2X50
| Crystal structure of Trypanothione reductase from Leishmania infantum in complex with NADPH and silver | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SILVER ION, ... | 著者 | Baiocco, P, Ilari, A, Colotti, G. | 登録日 | 2010-02-03 | 公開日 | 2011-01-12 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Inhibitory Effect of Silver Nanoparticles on Trypanothione Reductase Activity and Leishmania Infantum Proliferation Acs Med.Chem.Lett., 2, 2011
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5S9V
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5S9W
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