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Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS2)
分子名称:	DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ...
著者	Gao, Y, Cui, Y, Zhou, Z, Yang, W.
登録日	2018-12-04
公開日	2019-03-06
最終更新日	2019-12-18
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N7S

Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form II)
分子名称:	DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ...
著者	Gao, Y, Cui, Y, Zhou, Z, Yang, W.
登録日	2018-11-28
公開日	2019-03-06
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (4.6 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N7T

Structure of bacteriophage T7 E343Q mutant gp4 helicase-primase in complex with ssDNA, dTTP, AC dinucleotide and CTP (form III)
分子名称:	DNA (25-MER), DNA primase/helicase, MAGNESIUM ION, ...
著者	Gao, Y, Cui, Y, Zhou, Z, Yang, W.
登録日	2018-11-28
公開日	2019-03-06
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

5KFY

Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 4 degree
分子名称:	1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPT)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFC

Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 180s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(APGPCPGPTPCPAPT)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.5 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFL

Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 600s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPTP*A)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.65 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFX

Human DNA polymerase eta R61A-DNA ternary complex: reaction with 1 mM Mg2+ for 300s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.52 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFE

Human DNA polymerase eta-DNA ternary complex: reaction with 1 mM Mn2+ for 600s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(APGPCPGPTPCPAPT)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFO

Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 1 mM Mn2+ for 1800s
分子名称:	2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), CALCIUM ION, DNA (5'-D(APGPCPGPTPCPAPT)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.52 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KG1

Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 5 mM Mn2+ for 60s at 30 degree
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPTP*A)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.62 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KG6

Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Ca2+ for 60s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPTP*A)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-29
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFG

Human DNA polymerase eta-DNA ternary complex: reaction with 10 mM Mn2+ for 30s
分子名称:	1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-29
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.55 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KFR

Human DNA polymerase eta-DNA ternary complex with Sp-dATP-alpha-S: reaction with 20 mM Mn2+ for 600s
分子名称:	2'-DEOXYADENOSINE 5'-O-(1-THIOTRIPHOSPHATE), DIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPTP*(AS))-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

5KG4

Human DNA polymerase eta-DNA ternary complex: reaction first with 1 mM Mn2+ for 1800s then with 10 mM Mg2+ for 60s
分子名称:	2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, DIPHOSPHATE, DNA (5'-D(APGPCPGPTPCPAPTP*A)-3'), ...
著者	Gao, Y, Yang, W.
登録日	2016-06-12
公開日	2016-06-22
最終更新日	2023-09-27
実験手法	X-RAY DIFFRACTION (1.6 Å)
主引用文献	Capture of a third Mg2+ is essential for catalyzing DNA synthesis. Science, 352, 2016

6N7W

Structure of bacteriophage T7 leading-strand DNA polymerase (D5A/E7A)/Trx in complex with a DNA fork and incoming dTTP (from multiple lead complexes)
分子名称:	DNA (25-MER), DNA (77-MER), DNA-directed DNA polymerase, ...
著者	Gao, Y, Fox, T, Val, N, Yang, W.
登録日	2018-11-28
公開日	2019-03-06
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (4.5 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N9U

Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) interacting with primase domains of two gp4 subunits bound to an RNA/DNA hybrid and dTTP (from LagS1)
分子名称:	DNA (44-MER), DNA primase/helicase, DNA-directed DNA polymerase, ...
著者	Gao, Y, Fox, T, Val, N, Yang, W.
登録日	2018-12-04
公開日	2019-03-06
最終更新日	2019-12-18
実験手法	ELECTRON MICROSCOPY (3.7 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N9X

Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS3)
分子名称:	DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ...
著者	Gao, Y, Fox, T, Val, N, Yang, W.
登録日	2018-12-04
公開日	2019-03-06
最終更新日	2019-12-18
実験手法	ELECTRON MICROSCOPY (4.1 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N7V

Structure of bacteriophage T7 gp4 (helicase-primase, E343Q mutant) in complex with ssDNA, dTTP, AC dinucleotide, and CTP (from multiple lead complexes)
分子名称:	DNA (93-MER), DNA primase/helicase, MAGNESIUM ION, ...
著者	Gao, Y, Fox, T, Val, N, Yang, W.
登録日	2018-11-28
公開日	2019-03-06
最終更新日	2024-03-20
実験手法	ELECTRON MICROSCOPY (3.8 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

6N9V

Structure of bacteriophage T7 lagging-strand DNA polymerase (D5A/E7A) and gp4 (helicase/primase) bound to DNA including RNA/DNA hybrid, and an incoming dTTP (LagS1)
分子名称:	DNA primase/helicase, DNA-directed DNA polymerase, MAGNESIUM ION, ...
著者	Gao, Y, Fox, T, Val, N, Yang, W.
登録日	2018-12-04
公開日	2019-03-06
最終更新日	2019-12-18
実験手法	ELECTRON MICROSCOPY (4 Å)
主引用文献	Structures and operating principles of the replisome. Science, 363, 2019

4GX3

Product Complexes of Porcine Liver Fructose-1,6-bisphosphatase with mutation R22M Reveal a T-state Conformation
分子名称:	6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.25 Å)
主引用文献	Dimer-dimer Interface in Porcine Liver Fructose-1,6-bisphosphatase is Essential in Cooperative Binding of AMP To be Published

4GWW

Crystal Structure of product complexes of Porcine Liver Fructose-1,6-bisphosphatase with blocked subunit pair rotation
分子名称:	6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (3.2 Å)
主引用文献	Functional Importance of Subunit Pair Rotation in Regulation of Tetrameric Mammalian Fructose-1,6-bisphosphatase To be Published

4GX6

AMP Complexes of Porcine Liver Fructose-1,6-bisphosphatase with Mutation E192Q
分子名称:	6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Dimer-dimer Interface in Porcine Liver Fructose-1,6-bisphosphatase is Essential in Cooperative Binding of AMP To be Published

4GX4

AMP Complexes of Porcine Liver Fructose-1,6-bisphosphatase with mutation R22M
分子名称:	6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Dimer-dimer Interface in Porcine Liver Fructose-1,6-bisphosphatase is Essential in Cooperative Binding of AMP To be Published

4GWX

Crystal Structure of product complexes of Porcine Liver Fructose-1,6-bisphosphatase with restrained subunit pair rotation
分子名称:	6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase 1, MAGNESIUM ION, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-04
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (2.35 Å)
主引用文献	Functional Importance of Subunit Pair Rotation in Regulation of Tetrameric Mammalian Fructose-1,6-bisphosphatase To be Published

4GWY

Crystal Structure of AMP Complexes of Porcine Liver Fructose-1,6-bisphosphatase with Blocked Subunit Pair Rotation
分子名称:	6-O-phosphono-beta-D-fructofuranose, ADENOSINE MONOPHOSPHATE, Fructose-1,6-bisphosphatase 1, ...
著者	Gao, Y, Honzatko, R.B.
登録日	2012-09-03
公開日	2013-09-11
最終更新日	2023-09-13
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Functional Importance of Subunit Pair Rotation in Regulation of Tetrameric Mammalian Fructose-1,6-bisphosphatase To be Published

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