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6AXU
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BU of 6axu by Molmil
W203Y Epi-isozizaene synthase
分子名称: Epi-isozizaene synthase, MAGNESIUM ION, N-benzyl-N,N-diethylethanaminium, ...
著者Blank, P.N, Barrow, G.H, Christianson, D.W.
登録日2017-09-07
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.822 Å)
主引用文献Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.
Biochemistry, 56, 2017
1UGC
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BU of 1ugc by Molmil
HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY HIS (A65H)
分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-04-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGD
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BU of 1ugd by Molmil
HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)
分子名称: CARBONIC ANHYDRASE II, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGB
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BU of 1ugb by Molmil
HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY GLY (A65G)
分子名称: AZIDE ION, CARBONIC ANHYDRASE II, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGF
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BU of 1ugf by Molmil
HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY THR (A65T)
分子名称: AZIDE ION, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-04-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGA
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BU of 1uga by Molmil
HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY PHE (A65F)
分子名称: CARBONIC ANHYDRASE II, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGG
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BU of 1ugg by Molmil
HUMAN CARBONIC ANHYDRASE II[HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY SER (A65S)-ORTHORHOMBIC FORM
分子名称: CARBONIC ANHYDRASE II, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-01-27
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
1UGE
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BU of 1uge by Molmil
HUMAN CARBONIC ANHYDRASE II [HCAII] (E.C.4.2.1.1) MUTANT WITH ALA 65 REPLACED BY LEU (A65L)
分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
著者Scolnick, L.R, Christianson, D.W.
登録日1996-07-24
公開日1997-04-01
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis.
Biochemistry, 35, 1996
7S0L
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BU of 7s0l by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, S723F
分子名称: Terpene synthase
著者Ronnebaum, T.A, Christianson, D.W.
登録日2021-08-30
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
7S0H
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BU of 7s0h by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, S723Y
分子名称: Terpene synthase
著者Ronnebaum, T.A, Christianson, D.W.
登録日2021-08-30
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
7S0A
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BU of 7s0a by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, H786A
分子名称: Terpene synthase
著者Ronnebaum, T.A, Christianson, D.W.
登録日2021-08-30
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
7S09
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BU of 7s09 by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, F760A
分子名称: Terpene synthase
著者Ronnebaum, T.A, Christianson, D.W.
登録日2021-08-30
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
7S0M
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BU of 7s0m by Molmil
Crystal structure of Penicillium verruculosum copalyl diphosphate synthase (PvCPS) alpha prenyltransferase domain variant, S723T, bound with non-productive isopentenyl diphosphate
分子名称: 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Terpene synthase
著者Ronnebaum, T.A, Christianson, D.W.
登録日2021-08-30
公開日2021-10-13
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Engineering the Prenyltransferase Domain of a Bifunctional Assembly-Line Terpene Synthase.
Biochemistry, 60, 2021
5W5K
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BU of 5w5k by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with KV70
分子名称: 10-{[4-(hydroxycarbamoyl)phenyl]methyl}-5lambda~4~-pyrido[3,2-b][1,4]benzothiazin-10-ium, Histone deacetylase 6, POTASSIUM ION, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-06-15
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.
J.Med.Chem., 62, 2019
5VI6
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BU of 5vi6 by Molmil
Crystal structure of histone deacetylase 8 in complex with trapoxin A
分子名称: 1,2-ETHANEDIOL, 1,4-DIETHYLENE DIOXIDE, Histone deacetylase 8, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-04-14
公開日2017-09-06
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.237 Å)
主引用文献Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.
ACS Chem. Biol., 12, 2017
5WGI
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BU of 5wgi by Molmil
Ultrahigh resolution crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with TSA
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-07-14
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WGK
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BU of 5wgk by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with HPB
分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Hdac6 protein, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-07-14
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.822 Å)
主引用文献Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WGL
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BU of 5wgl by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ricolinostat (ACY-1215)
分子名称: 1,2-ETHANEDIOL, 2-(diphenylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide, CITRATE ANION, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-07-14
公開日2017-12-06
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WGM
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BU of 5wgm by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ACY-1083
分子名称: 1,2-ETHANEDIOL, 2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ...
著者Porter, N.J, Christianson, D.W.
登録日2017-07-14
公開日2017-12-06
最終更新日2024-12-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8CA2
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BU of 8ca2 by Molmil
ENGINEERING THE HYDROPHOBIC POCKET OF CARBONIC ANHYDRASE II
分子名称: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION
著者Alexander, R.S, Christianson, D.W.
登録日1991-07-09
公開日1992-07-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Engineering the hydrophobic pocket of carbonic anhydrase II.
Biochemistry, 30, 1991
1A42
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BU of 1a42 by Molmil
HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE
分子名称: (4R)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, CARBONIC ANHYDRASE II, MERCURY (II) ION, ...
著者Boriack-Sjodin, P.A, Christianson, D.W.
登録日1998-02-10
公開日1999-03-23
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination.
Protein Sci., 7, 1998
7U8Z
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BU of 7u8z by Molmil
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 (CD2) complexed with fluorinated peptoid inhibitor
分子名称: 1,2-ETHANEDIOL, 4-({N-[2-(benzylamino)-2-oxoethyl]-4-(dimethylamino)benzamido}methyl)-3-fluoro-N-hydroxybenzamide, ACETATE ION, ...
著者Watson, P.R, Cragin, A.D, Christianson, D.W.
登録日2022-03-09
公開日2022-11-23
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Development of Fluorinated Peptoid-Based Histone Deacetylase (HDAC) Inhibitors for Therapy-Resistant Acute Leukemia.
J.Med.Chem., 65, 2022
1AS4
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BU of 1as4 by Molmil
CLEAVED ANTICHYMOTRYPSIN A349R
分子名称: ACETATE ION, ANTICHYMOTRYPSIN
著者Lukacs, C.M, Christianson, D.W.
登録日1997-08-12
公開日1998-02-25
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Engineering an anion-binding cavity in antichymotrypsin modulates the "spring-loaded" serpin-protease interaction.
Biochemistry, 37, 1998
5RLA
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BU of 5rla by Molmil
ALTERING THE BINUCLEAR MANGANESE CLUSTER OF ARGINASE DIMINISHES THERMOSTABILITY AND CATALYTIC FUNCTION
分子名称: ARGINASE, MANGANESE (II) ION
著者Scolnick, L.R, Kanyo, Z.F, Christianson, D.W.
登録日1997-05-07
公開日1998-05-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Altering the binuclear manganese cluster of arginase diminishes thermostability and catalytic function.
Biochemistry, 36, 1997
5TD7
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BU of 5td7 by Molmil
Crystal structure of histone deacetylase 10
分子名称: 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, PENTAETHYLENE GLYCOL, PHOSPHATE ION, ...
著者Hai, Y, Shinsky, S.A, Porter, N.J, Christianson, D.W.
登録日2016-09-17
公開日2017-05-24
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Histone deacetylase 10 structure and molecular function as a polyamine deacetylase.
Nat Commun, 8, 2017

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