5WGM
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ACY-1083
Summary for 5WGM
| Entry DOI | 10.2210/pdb5wgm/pdb |
| Descriptor | Hdac6 protein, ZINC ION, POTASSIUM ION, ... (8 entities in total) |
| Functional Keywords | histone deacetylase, hydrolase inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Danio rerio (Zebrafish) |
| Total number of polymer chains | 3 |
| Total formula weight | 125141.41 |
| Authors | Porter, N.J.,Christianson, D.W. (deposition date: 2017-07-14, release date: 2017-12-06, Last modification date: 2023-10-04) |
| Primary citation | Porter, N.J.,Mahendran, A.,Breslow, R.,Christianson, D.W. Unusual zinc-binding mode of HDAC6-selective hydroxamate inhibitors. Proc. Natl. Acad. Sci. U.S.A., 114:13459-13464, 2017 Cited by PubMed: 29203661DOI: 10.1073/pnas.1718823114 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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