5WGM
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with ACY-1083
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Hdac6 protein | polymer | 364 | 40285.5 | 3 | UniProt (A7YT55) Pfam (PF00850) UniProt (by SIFTS) (F8W4B7) | Danio rerio (Zebrafish) | histone deacetylase 6 |
| 2 | D, NA, U (A, C, B) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) | |||
| 3 | E, F, OA, PA, V... (A, C, B) | POTASSIUM ION | non-polymer | 39.1 | 6 | Chemie (K) | |||
| 4 | G, QA, X (A, C, B) | 2-[(4,4-difluoro-1-phenylcyclohexyl)amino]-N-hydroxypyrimidine-5-carboxamide | non-polymer | 348.3 | 3 | Chemie (AH7) | |||
| 5 | AA, AB, BA, BB, CA... (B, C, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 37 | Chemie (EDO) | |||
| 6 | CB, S (C, A) | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 2 | Chemie (PGE) | |||
| 7 | DB, T (C, A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 8 | EB, FB, GB (A, B, C) | water | water | 18.0 | 962 | Chemie (HOH) |
Sequence modifications
A, B, C: 440 - 798 (UniProt: A7YT55)
| PDB | External Database | Details |
|---|---|---|
| Ser 435 | - | expression tag |
| Asn 436 | - | expression tag |
| Ala 437 | - | expression tag |
| Gly 438 | - | expression tag |
| Gly 439 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 120856.5 | |
| Non-Polymers* | Number of molecules | 53 |
| Total formula weight | 4285.0 | |
| All* | Total formula weight | 125141.4 |
