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Structure of the Varicella Zoster Virus (VZV) gI binding domain of glycoprotein E (gE) in complex with human Fab 1A2 and 1E12
分子名称:	Envelope glycoprotein E, Fab 1A2 Heavy Chain, Fab 1A2 Light Chain, ...
著者	Seraj, N, Holzapfel, G, Harshbarger, W.
登録日	2023-11-30
公開日	2024-10-09
実験手法	X-RAY DIFFRACTION (3.09 Å)
主引用文献	Structures of the Varicella Zoster Virus Glycoprotein E and Epitope Mapping of Vaccine-Elicited Antibodies Vaccines (Basel), 12, 2024

5T5F

Neisseria meningitidis factor H binding protein in complex with monoclonal antibody JAR5
分子名称:	Factor H binding protein variant B24, Monoclonal antibody Jar5 heavy chain, Monoclonal antibody Jar5 light chain
著者	Malito, E.
登録日	2016-08-30
公開日	2016-11-09
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.98 Å)
主引用文献	Neisseria meningitidis factor H-binding protein bound to monoclonal antibody JAR5: implications for antibody synergy. Biochem. J., 473, 2016

8EPN

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 in the 3-RBD Down conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者	Williams, J.A, Harshbarger, W.
登録日	2022-10-06
公開日	2023-06-21
実験手法	ELECTRON MICROSCOPY (2.8 Å)
主引用文献	Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity. Sci Adv, 9, 2023

8EPQ

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs exposed
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者	Williams, J.A, Harshbarger, W.
登録日	2022-10-06
公開日	2023-06-21
最終更新日	2024-10-16
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity. Sci Adv, 9, 2023

8EPP

Cryo-EM structure of SARS-CoV-2 Spike trimer S2D14 with two RBDs in the open conformation
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
著者	Williams, J.A, Harshbarger, W.
登録日	2022-10-06
公開日	2023-06-21
実験手法	ELECTRON MICROSCOPY (3.1 Å)
主引用文献	Structural and computational design of a SARS-CoV-2 spike antigen with improved expression and immunogenicity. Sci Adv, 9, 2023

5N4J

human Fab fragment 10C3 against NHBA from Neisseria meningitidis
分子名称:	HEAVY CHAIN, LIGHT CHAIN
著者	Maritan, M, Malito, E.
登録日	2017-02-10
公開日	2017-05-31
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (1.503 Å)
主引用文献	Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA. Acta Crystallogr F Struct Biol Commun, 73, 2017

5NYX

human Fab fragment 5H2 against NHBA from Neisseria meningitidis
分子名称:	GLYCEROL, HEAVY CHAIN, LIGHT CHAIN, ...
著者	Malito, E, Maritan, M.
登録日	2017-05-12
公開日	2018-05-30
最終更新日	2024-10-16
実験手法	X-RAY DIFFRACTION (1.88 Å)
主引用文献	Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. PLoS ONE, 13, 2018

5O14

Co-crystal structure of a cross-reactive bactericidal human antibody targeting meningococcal vaccine antigen factor H binding protein
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, Fab 1A12 Heavy Chain, ...
著者	Lopez-Sagaseta, J.
登録日	2017-05-18
公開日	2018-02-14
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.195 Å)
主引用文献	Crystal structure reveals vaccine elicited bactericidal human antibody targeting a conserved epitope on meningococcal fHbp. Nat Commun, 9, 2018

5O1R

human Fab 5H2 bound to NHBA-C3 from Neisseria meningitidis serogroup B
分子名称:	1,2-ETHANEDIOL, GNA2132, IGH@ protein, ...
著者	Malito, E, Maritan, M.
登録日	2017-05-19
公開日	2018-05-30
最終更新日	2024-01-17
実験手法	X-RAY DIFFRACTION (2.86 Å)
主引用文献	Structures of NHBA elucidate a broadly conserved epitope identified by a vaccine induced antibody. PLoS ONE, 13, 2018

7MPG

Cryo-EM structure of Prefusion-stabilized RSV F (DS-Cav1) in complex with Fab AM14
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者	Abeyrathne, P.D, Malito, E, Harshbarger, W.D.
登録日	2021-05-04
公開日	2021-09-08
最終更新日	2024-11-06
実験手法	ELECTRON MICROSCOPY (3.4 Å)
主引用文献	Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein. Mabs, 13

7MMN

Crystal Structure of the Prefusion RSV F Glycoprotein bound by human antibody AM14
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, AM14 Fab Heavy Chain, AM14 Fab Light Chain, ...
著者	Harshbarger, W, Malito, E.
登録日	2021-04-29
公開日	2021-09-08
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (3.57 Å)
主引用文献	Improved epitope resolution of the prefusion trimer-specific antibody AM14 bound to the RSV F glycoprotein. Mabs, 13, 2021

5N4G

human Fab fragment 12E1 against NHBA from Neisseria meningitidis
分子名称:	1,2-ETHANEDIOL, HEAVY CHAIN, LIGHT CHAIN, ...
著者	Maritan, M, Malito, E.
登録日	2017-02-10
公開日	2017-05-31
最終更新日	2024-10-23
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Crystal structures of human Fabs targeting the Bexsero meningococcal vaccine antigen NHBA. Acta Crystallogr F Struct Biol Commun, 73, 2017

8ULK

Prefusion RSV F bound by neutralizing antibody 1G12
分子名称:	1G12 Fab heavy chain, 1G12 Fab light chain, Fusion glycoprotein F0,Fibritin, ...
著者	Harshbarger, W.D, Andreano, E, Malito, E.
登録日	2023-10-16
公開日	2024-11-06
実験手法	X-RAY DIFFRACTION (4.28 Å)
主引用文献	Structural and functional properties of monoclonal and vaccine-induced antibodies targeting epitopes of emerging RSV variants To be published

6W5D

Crystal Structure of Fab RSB1
分子名称:	RSB1 Fab Heavy Chain, RSB1 Fab Light Chain
著者	Harshbarger, W, Chandramouli, S, Malito, M.
登録日	2020-03-13
公開日	2020-11-11
最終更新日	2024-10-09
実験手法	X-RAY DIFFRACTION (2 Å)
主引用文献	Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. Plos Pathog., 16, 2020

6W52

Prefusion RSV F bound by neutralizing antibody RSB1
分子名称:	Fusion glycoprotein F0, Fusion glycoprotein F1 fused with Fibritin trimerization domain, RSB1 Fab Heavy Chain, ...
著者	Harshbarger, W, Chandramouli, S, Malito, M.
登録日	2020-03-12
公開日	2020-11-11
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (3.74 Å)
主引用文献	Convergent structural features of respiratory syncytial virus neutralizing antibodies and plasticity of the site V epitope on prefusion F. Plos Pathog., 16, 2020

8ULH

Fab of RSV neutralizing antibody 1G12
分子名称:	1G12 Fab heavy chain, 1G12 Fab light chain
著者	Harshbarger, W.D, Andreano, E, Malito, E.
登録日	2023-10-16
公開日	2024-11-06
実験手法	X-RAY DIFFRACTION (1.69 Å)
主引用文献	Structural and functional properties of monoclonal and vaccine-induced antibodies targeting epitopes of emerging RSV variants To be published

8ULJ

Prefusion RSV F bound by neutralizing antibody 2E08
分子名称:	2E08 Fab Heavy Chain, 2E08 Fab Light Chain, Fusion glycoprotein F0,Fibritin, ...
著者	Harshbarger, W.D, Andreano, E, Malito, E.
登録日	2023-10-16
公開日	2024-11-06
実験手法	X-RAY DIFFRACTION (3 Å)
主引用文献	Structural and functional properties of monoclonal and vaccine-induced antibodies targeting epitopes of emerging RSV variants To be published

6VJB

Crystal structure of a catalytically inactive CXC Chemokine-degrading protease SpyCEP from Streptococcus pyogenes
分子名称:	1,2-ETHANEDIOL, CALCIUM ION, Putative cell envelope proteinase
著者	Malito, E, Rouse, S.
登録日	2020-01-15
公開日	2020-04-15
最終更新日	2023-10-11
実験手法	X-RAY DIFFRACTION (2.24 Å)
主引用文献	Structure, dynamics and immunogenicity of a catalytically inactive CXC chemokine-degrading protease SpyCEP from Streptococcus pyogenes. Comput Struct Biotechnol J, 18, 2020

2K1Q

NMR structure of hepatitis c virus ns3 serine protease complexed with the non-covalently bound phenethylamide inhibitor
分子名称:	NS3 PROTEASE, PHENETHYLAMIDE, ZINC ION
著者	Eliseo, T, Gallo, M, Pennestri, M, Bazzo, R, Cicero, D.O.
登録日	2008-03-13
公開日	2009-02-03
最終更新日	2023-11-15
実験手法	SOLUTION NMR
主引用文献	Binding of a noncovalent inhibitor exploiting the S' region stabilizes the hepatitis C virus NS3 protease conformation in the absence of cofactor. J.Mol.Biol., 385, 2009

4G1H

Group B Streptococcus Pilus Island 1 Sortase C2
分子名称:	CALCIUM ION, Sortase family protein
著者	Cozzi, R, Prigozhin, D.M, Alber, T.
登録日	2012-07-10
公開日	2012-12-05
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Structural basis for group B streptococcus pilus 1 sortases C regulation and specificity. Plos One, 7, 2012

4AE0

Crystal structure of diphtheria toxin mutant CRM197
分子名称:	DIPHTHERIA TOXIN
著者	Malito, E, Spraggon, G.
登録日	2012-01-04
公開日	2012-03-28
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (1.996 Å)
主引用文献	Structural Basis for Lack of Toxicity of the Diphtheria Toxin Mutant Crm197. Proc.Natl.Acad.Sci.USA, 109, 2012

4G1J

Sortase C1 of GBS Pilus Island 1
分子名称:	Sortase family protein
著者	Cozzi, R, Prigozhin, D.M, Alber, T.
登録日	2012-07-10
公開日	2012-12-05
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.75 Å)
主引用文献	Structural basis for group B streptococcus pilus 1 sortases C regulation and specificity. Plos One, 7, 2012

4AE1

Crystal structure of diphtheria toxin mutant CRM197 in complex with nicotinamide
分子名称:	DIPHTHERIA TOXIN, NICOTINAMIDE
著者	Malito, E, Spraggon, G.
登録日	2012-01-04
公開日	2012-03-28
最終更新日	2023-12-20
実験手法	X-RAY DIFFRACTION (2.078 Å)
主引用文献	Structural Basis for Lack of Toxicity of the Diphtheria Toxin Mutant Crm197. Proc.Natl.Acad.Sci.USA, 109, 2012

2XTJ

The crystal structure of PCSK9 in complex with 1D05 Fab
分子名称:	CALCIUM ION, FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05, ...
著者	Di Marco, S, Volpari, C, Carfi, A.
登録日	2010-10-10
公開日	2010-11-03
最終更新日	2024-11-06
実験手法	X-RAY DIFFRACTION (2.7 Å)
主引用文献	A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo. J.Lipid Res., 52, 2011

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