1P0D
| CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS tRNA-GUANINE TRANSGLYCOSYLASE (TGT) CRYSTALLISED AT PH 5.5 | 分子名称: | Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-10 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme
tRNA-guanine transglycosylase and their implications for substrate selectivity,
reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1Q66
| CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2-AMINO-6-AMINOMETHYL-8-phenylsulfanylmethyl-3H-QUINAZOLIN-4-ONE crystallized at pH 5.5 | 分子名称: | 2-AMINO-6-AMINOMETHYL-8-PHENYLSULFANYLMETHYL-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Stubbs, M.T, Garcia, G.A, Klebe, G. | 登録日 | 2003-08-12 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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1QOI
| U4/U6 snRNP-specific cyclophilin SnuCyp-20 | 分子名称: | SNUCYP-20 | 著者 | Reidt, U, Reuter, K, Achsel, T, Ingelfinger, D, Luehrmann, R, Ficner, R. | 登録日 | 1999-11-09 | 公開日 | 2000-04-10 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the Human U4/U6 Small Nuclear Ribonucleoproteinparticle-Specificsnucyp-20, a Nuclear Cyclophilin J.Biol.Chem., 275, 2000
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1R5Y
| Crystal Structure of TGT in complex with 2,6-Diamino-3H-Quinazolin-4-one Crystallized at PH 5.5 | 分子名称: | 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Garcia, G.A, Stubbs, M.T, Klebe, G. | 登録日 | 2003-10-13 | 公開日 | 2004-04-13 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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1Q4W
| CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE | 分子名称: | 2,6-DIAMINO-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Stubbs, M.T, Garcia, G.A, Klebe, G. | 登録日 | 2003-08-04 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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1Q65
| CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2,6-DIAMINO-8-(2-dimethylaminoethylsulfanylmethyl)-3H-QUINAZOLIN-4-ONE crystallized at pH 5.5 | 分子名称: | 2,6-DIAMINO-8-(2-DIMETHYLAMINOETHYLSULFANYLMETHYL)-3H-QUINAZOLIN-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Stubbs, M.T, Garcia, G.A, Klebe, G. | 登録日 | 2003-08-12 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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1Q63
| CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2,6-Diamino-8-(1H-imidazol-2-ylsulfanylmethyl)-3H-quinazoline-4-one crystallized at pH 5.5 | 分子名称: | 2,6-DIAMINO-8-(1H-IMIDAZOL-2-YLSULFANYLMETHYL)-3H-QUINAZOLINE-4-ONE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Meyer, E, Reuter, K, Stubbs, M.T, Garcia, G.A, Klebe, G. | 登録日 | 2003-08-12 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338, 2004
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1OZM
| Y106F mutant of Z. mobilis TGT | 分子名称: | Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-09 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme
tRNA-guanine transglycosylase and their implications for substrate selectivity,
reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1P0E
| CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS tRNA-GUANINE TRANSGLYCOSYLASE (TGT) COCRYSTALLISED WITH PREQ1 AT PH 5.5 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Brenk, R, Stubbs, M.T, Heine, A, Reuter, K, Klebe, G. | 登録日 | 2003-04-10 | 公開日 | 2003-09-30 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase
and their implications for substrate selectivity, reaction mechanism and structure-based drug design Chembiochem, 4, 2003
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1PXG
| Crystal structure of the mutated tRNA-guanine transglycosylase (TGT) D280E complexed with preQ1 | 分子名称: | 7-DEAZA-7-AMINOMETHYL-GUANINE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Kittendorf, J.D, Sgraja, T, Reuter, K, Klebe, G, Garcia, G.A. | 登録日 | 2003-07-04 | 公開日 | 2003-09-09 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | An essential role for aspartate 264 in catalysis by tRNA-guanine transglycosylase from Escherichia coli. J.Biol.Chem., 278, 2003
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5I09
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5I06
| tRNA-guanine Transglycosylase (TGT) in co-crystallized complex with 6-Amino-4-[2-(4-methoxyphenyl)ethyl]-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one | 分子名称: | 1,2-ETHANEDIOL, 6-AMINO-4-[2-(4-METHOXYPHENYL)ETHYL]-1,7-DIHYDRO-8H-IMIDAZO[4,5-G]QUINAZOLIN-8-ONE, GLYCEROL, ... | 著者 | Ehrmann, F.R, Heine, A, Klebe, G. | 登録日 | 2016-02-03 | 公開日 | 2017-02-15 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.36 Å) | 主引用文献 | Co-crystallization, Isothermal titration calorimetry and nanoESI-MS reveal dimer disturbing inhibitors To be Published
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3UNT
| tRNA-guanine transglycosylase E339Q mutant | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Jakobi, S, Heine, A, Klebe, G. | 登録日 | 2011-11-16 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme. Proteins, 82, 2014
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3UVI
| tRNA-guanine transglycosylase C158S C281S W326E E339Q mutant | 分子名称: | CHLORIDE ION, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Jakobi, S, Heine, A, Klebe, G. | 登録日 | 2011-11-30 | 公開日 | 2012-11-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme. Proteins, 82, 2014
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3HFY
| Mutant of tRNA-guanine transglycosylase (K52M) | 分子名称: | Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Ritschel, T, Klebe, G. | 登録日 | 2009-05-13 | 公開日 | 2009-08-18 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | An Integrative Approach Combining Noncovalent Mass Spectrometry, Enzyme Kinetics and X-ray Crystallography to Decipher Tgt Protein-Protein and Protein-RNA Interaction J.Mol.Biol., 393, 2009
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7YMV
| Cryo-EM structure of MERS-CoV spike protein, Two RBD-up conformation 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (6.74 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YMW
| Cryo-EM structure of MERS-CoV spike protein, One RBD-up conformation 4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (6.05 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YMX
| Cryo-EM structure of MERS-CoV spike protein, One RBD-up conformation 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.44 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YMT
| Cryo-EM structure of MERS-CoV spike protein, Two RBD-up conformation 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (6.55 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YN0
| Cryo-EM structure of MERS-CoV spike protein, all RBD-down conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-10-16 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YMY
| Cryo-EM structure of MERS-CoV spike protein, One RBD-up conformation 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.96 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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7YMZ
| Cryo-EM structure of MERS-CoV spike protein, intermediate conformation | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Hsu, S.T.D, Chang, N.E, Weng, Z.W, Yang, T.J, Draczkowski, P. | 登録日 | 2022-07-29 | 公開日 | 2023-08-09 | 最終更新日 | 2024-09-04 | 実験手法 | ELECTRON MICROSCOPY (4.39 Å) | 主引用文献 | Rapid simulation of glycoprotein structures by grafting and steric exclusion of glycan conformer libraries. Cell, 187, 2024
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4DXX
| TGT K52M mutant crystallized at pH 8.5 | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, Queuine tRNA-ribosyltransferase, ... | 著者 | Jakobi, S, Ritschel, T, Heine, A, Klebe, G. | 登録日 | 2012-02-28 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Hot-spot analysis to dissect the functional protein-protein interface of a tRNA-modifying enzyme. Proteins, 82, 2014
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4DY1
| tRNA-guanine transglycosylase F92C C158S C281S mutant | 分子名称: | CHLORIDE ION, Queuine tRNA-ribosyltransferase, ZINC ION | 著者 | Jakobi, S, Heine, A, Klebe, G. | 登録日 | 2012-02-28 | 公開日 | 2013-03-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.045 Å) | 主引用文献 | What Glues a Homodimer Together: Systematic Analysis of the Stabilizing Effect of an Aromatic Hot Spot in the Protein-Protein Interface of the tRNA-Modifying Enzyme Tgt. Acs Chem.Biol., 10, 2015
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4L56
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