1Q63

CRYSTAL STRUCTURE OF TGT IN COMPLEX WITH 2,6-Diamino-8-(1H-imidazol-2-ylsulfanylmethyl)-3H-quinazoline-4-one crystallized at pH 5.5

Summary for 1Q63

Entry DOI	10.2210/pdb1q63/pdb
Related	1k4g 1pud 1Q4W 1Q65 1Q66
Descriptor	Queuine tRNA-ribosyltransferase, ZINC ION, 2,6-DIAMINO-8-(1H-IMIDAZOL-2-YLSULFANYLMETHYL)-3H-QUINAZOLINE-4-ONE, ... (4 entities in total)
Functional Keywords	transferase
Biological source	Zymomonas mobilis
Total number of polymer chains	1
Total formula weight	43279.44
Authors	Brenk, R.,Meyer, E.,Reuter, K.,Stubbs, M.T.,Garcia, G.A.,Klebe, G. (deposition date: 2003-08-12, release date: 2004-04-13, Last modification date: 2023-08-16)
Primary citation	Brenk, R.,Meyer, E.,Reuter, K.,Stubbs, M.T.,Garcia, G.A.,Diederich, F.,Klebe, G. Crystallographic Study of Inhibitors of tRNA-guanine Transglycosylase Suggests a New Structure-based Pharmacophore for Virtual Screening. J.Mol.Biol., 338:55-75, 2004 Cited by PubMed: 15050823 DOI: 10.1016/j.jmb.2004.02.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation