6LP8
 
 | | Crystal structure of human DHODH in complex with inhibitor 1243 | | 分子名称: | 3-[4-[3-(dimethylamino)phenyl]-3,5-bis(fluoranyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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6M6I
 | | Structure of HSV2 B-capsid portal vertex | | 分子名称: | Coiled coils chain 1, Coiled coils chain 2, Major capsid protein, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-10 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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6M6H
 | | Structure of HSV2 C-capsid portal vertex | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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6M6G
 | | Structure of HSV2 viron capsid portal vertex | | 分子名称: | Capsid vertex component 1, Capsid vertex component 2, Coiled coils, ... | | 著者 | Wang, X.X, Wang, N. | | 登録日 | 2020-03-14 | | 公開日 | 2021-03-24 | | 実験手法 | ELECTRON MICROSCOPY (5.39 Å) | | 主引用文献 | Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation.
Protein Cell, 11, 2020
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4PJW
 | | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1), with bound MES | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | | 著者 | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | | 登録日 | 2014-05-12 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
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4PJU
 | | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) | | 分子名称: | Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | | 著者 | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | | 登録日 | 2014-05-12 | | 公開日 | 2014-08-27 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
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4PK7
 | | crystal structure of human Stromal Antigen 2 (SA2) in complex with Sister Chromatid Cohesion protein 1 (Scc1) with bound MES, native proteins | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cohesin subunit SA-2, Double-strand-break repair protein rad21 homolog | | 著者 | Hara, K, Chen, Z, Tomchick, D.R, Yu, H. | | 登録日 | 2014-05-13 | | 公開日 | 2014-09-03 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Structure of cohesin subcomplex pinpoints direct shugoshin-Wapl antagonism in centromeric cohesion.
Nat.Struct.Mol.Biol., 21, 2014
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6LP7
 | | Crystal structure of human DHODH in complex with inhibitor 0944 | | 分子名称: | 3-[3,5-bis(fluoranyl)-4-(3-methoxyphenyl)phenyl]benzo[f]benzotriazole-4,9-dione, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ... | | 著者 | Chen, Q, Yu, Y. | | 登録日 | 2020-01-09 | | 公開日 | 2020-09-30 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
J.Med.Chem., 63, 2020
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4JZR
 | | Structure of Prolyl Hydroxylase Domain-containing Protein (PHD) with Inhibitors | | 分子名称: | 1,2-ETHANEDIOL, 2-(biphenyl-4-yl)-8-[(1-methyl-1H-imidazol-2-yl)methyl]-2,8-diazaspiro[4.5]decan-1-one, Egl nine homolog 1, ... | | 著者 | Ma, Y, Yang, L. | | 登録日 | 2013-04-03 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Novel complex crystal structure of prolyl hydroxylase domain-containing protein 2 (PHD2): 2,8-Diazaspiro[4.5]decan-1-ones as potent, orally bioavailable PHD2 inhibitors
Bioorg.Med.Chem., 21, 2013
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8CYA
 | | SARS-CoV-2 Spike protein in complex with a pan-sarbecovirus nanobody 2-67 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Huang, W, Taylor, D. | | 登録日 | 2022-05-23 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Superimmunity by pan-sarbecovirus nanobodies.
Cell Rep, 39, 2022
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8CXQ
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8CYC
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8CY6
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8HNB
 | | Cryo-EM structure of human OATP1B1 in apo state | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1 | | 著者 | Shan, Z, Yang, X, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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8CYJ
 | | RBD of SARS-CoV-2 Spike protein in complex with pan-sarbecovirus nanobodies 2-10, 2-67, 2-62 and 1-25 | | 分子名称: | Spike glycoprotein, pan-sarbecovirus nanobody 1-25, pan-sarbecovirus nanobody 2-10, ... | | 著者 | Huang, W, Taylor, D. | | 登録日 | 2022-05-23 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-07-13 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | Superimmunity by pan-sarbecovirus nanobodies.
Cell Rep, 39, 2022
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8HNH
 | | Cryo-EM structure of human OATP1B1 in complex with simeprevir | | 分子名称: | (2R,3aR,10Z,11aS,12aR,14aR)-N-(cyclopropylsulfonyl)-2-({7-methoxy-8-methyl-2-[4-(1-methylethyl)-1,3-thiazol-2-yl]quinolin-4-yl}oxy)-5-methyl-4,14-dioxo-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydrocyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Shan, Z, Yang, X, Zhang, Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-09-13 | | 最終更新日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1.
Cell Res., 33, 2023
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8CYB
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8CYD
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8CY9
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8CXN
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8CY7
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7F70
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7F74
 | | Rv3094c in complex with FMN. | | 分子名称: | FLAVIN MONONUCLEOTIDE, Rv3094c | | 著者 | Wang, Z.X, Ouyang, S.Y. | | 登録日 | 2021-06-27 | | 公開日 | 2022-06-29 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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8D0Z
 | | S728-1157 IgG in complex with SARS-CoV-2-6P-Mut7 Spike protein (focused refinement) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, S728-1157 Fab heavy chain variable region, S728-1157 Fab light chain variable region, ... | | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | | 登録日 | 2022-05-26 | | 公開日 | 2023-03-22 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Site of vulnerability on SARS-CoV-2 spike induces broadly protective antibody against antigenically distinct Omicron subvariants.
J.Clin.Invest., 133, 2023
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7F72
 | | Rv3094c in complex with FAD and ETH. | | 分子名称: | 2-ethylpyridine-4-carboximidothioic acid, FLAVIN MONONUCLEOTIDE, Rv3094c | | 著者 | Wang, Z.X, Ouyang, S.Y. | | 登録日 | 2021-06-27 | | 公開日 | 2022-07-13 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene.
Commun Biol, 6, 2023
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