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9N95
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BU of 9n95 by Molmil
Human TMEM63A mutant V53M closed state
分子名称: CSC1-like protein 1
著者Zheng, W, Fu, T.M, Holt, J.R.
登録日2025-02-10
公開日2025-06-11
最終更新日2025-06-18
実験手法ELECTRON MICROSCOPY (3.65 Å)
主引用文献Structural and functional basis of mechanosensitive TMEM63 channelopathies.
Neuron, 2025
9N93
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BU of 9n93 by Molmil
Human TMEM63A mutant V53M lipid-open state
分子名称: CSC1-like protein 1
著者Zheng, W, Fu, T.M, Holt, J.R.
登録日2025-02-10
公開日2025-06-11
最終更新日2025-06-18
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Structural and functional basis of mechanosensitive TMEM63 channelopathies.
Neuron, 2025
7XFG
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BU of 7xfg by Molmil
NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #1
分子名称: Histone acetyltransferase p300, NUT family member 1, ZINC ION
著者Yu, D, Zeng, L, Zhou, M.-M.
登録日2022-04-01
公開日2023-04-12
最終更新日2024-10-30
実験手法SOLUTION NMR
主引用文献Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma.
Nat Commun, 14, 2023
7XEZ
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BU of 7xez by Molmil
NMR solution structures of p300 TAZ2 domain in complex with BRD4-NUT F1c domain binding motif #2
分子名称: Histone acetyltransferase p300,NUT family member 1, ZINC ION
著者Yu, D, Zeng, L, Zhou, M.-M.
登録日2022-03-31
公開日2023-04-12
最終更新日2024-10-30
実験手法SOLUTION NMR
主引用文献Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma.
Nat Commun, 14, 2023
6UV8
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BU of 6uv8 by Molmil
Crystal structure of a far-red cyanobacteriochrome photoreceptor at room temperature
分子名称: Multi-sensor signal transduction histidine kinase, PHYCOCYANOBILIN
著者Yang, X, Ren, Z, Bandara, S.
登録日2019-11-01
公開日2020-11-04
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献Crystal structure of a far-red-sensing cyanobacteriochrome reveals an atypical bilin conformation and spectral tuning mechanism.
Proc.Natl.Acad.Sci.USA, 118, 2021
5Y1Y
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BU of 5y1y by Molmil
Complex structure of nitroxoline with the first bromodomain of BRD4
分子名称: 5-nitroquinolin-8-ol, Bromodomain-containing protein 4
著者Jiang, H, Luo, C.
登録日2017-07-21
公開日2017-11-15
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.912 Å)
主引用文献Discovery of novel BET inhibitors by drug repurposing of nitroxoline and its analogues.
Org. Biomol. Chem., 15, 2017
7MSD
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BU of 7msd by Molmil
Structure of EED bound to EEDi-6068
分子名称: (9aP,12aR)-4-(2,2-difluoropropyl)-12-{[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,8,11,12a-pentaazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, FORMIC ACID, Polycomb protein EED
著者Petrunak, E, Stuckey, J.
登録日2021-05-11
公開日2021-10-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J.Med.Chem., 64, 2021
7MSB
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Structure of EED bound to EEDi-4259
分子名称: (9aM,12aS)-12-{[(5-fluoro-1-benzofuran-4-yl)methyl]amino}-7-(trifluoromethyl)-4,5-dihydro-3H-2,4,11,12a-tetraazabenzo[4,5]cycloocta[1,2,3-cd]inden-3-one, Polycomb protein EED
著者Petrunak, E, Stuckey, J.
登録日2021-05-11
公開日2021-10-20
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression.
J.Med.Chem., 64, 2021
7MXD
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BU of 7mxd by Molmil
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J038 in complex with HIV-1 Env
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ...
著者Zhou, T, Gao, F.
登録日2021-05-19
公開日2022-03-30
最終更新日2025-06-04
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.
Adv Sci, 9, 2022
7N28
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BU of 7n28 by Molmil
Cryo-EM structure of broadly neutralizing V2-apex-targeting antibody J033 in complex with HIV-1 Env
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC117 antibody heavy chain, ...
著者Zhou, T, Gao, F.
登録日2021-05-28
公開日2022-04-06
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Development of Neutralization Breadth against Diverse HIV-1 by Increasing Ab-Ag Interface on V2.
Adv Sci, 9, 2022
5H7P
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BU of 5h7p by Molmil
NMR structure of the Vta1NTD-Did2(176-204) complex
分子名称: Vacuolar protein sorting-associated protein VTA1, Vacuolar protein-sorting-associated protein 46
著者Shen, J, Yang, Z, Wild, C.J.
登録日2016-11-20
公開日2016-12-21
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR studies on the interactions between yeast Vta1 and Did2 during the multivesicular bodies sorting pathway
Sci Rep, 6, 2016
5Y9P
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BU of 5y9p by Molmil
Staphylococcus aureus RNase HII
分子名称: GLYCEROL, Ribonuclease HII
著者Hang, T, Wu, M, Zhang, X.
登録日2017-08-26
公開日2018-08-01
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural insights into a novel functional dimer of Staphylococcus aureus RNase HII
Biochem. Biophys. Res. Commun., 503, 2018
6C0S
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BU of 6c0s by Molmil
Factor XIA in complex with the inhibitor methyl (4-{6-[(1S)-2-[(3R)-1-acetylpiperidin-3-yl]-1-({(2E)-3-[5-chloro-2- (1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)ethyl]-3-chloropyridazin-4-yl}phenyl) carbamate
分子名称: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
著者Sheriff, S.
登録日2018-01-02
公開日2018-03-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6MNL
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BU of 6mnl by Molmil
NMR solution structures of second bromodomain of BRD4 with FOXO3a peptide
分子名称: Bromodomain-containing protein 4, FOXO3a peptide
著者Zeng, L, Zhou, M.-M.
登録日2018-10-02
公開日2018-10-31
最終更新日2024-11-20
実験手法SOLUTION NMR
主引用文献Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Nat Commun, 9, 2018
7R77
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BU of 7r77 by Molmil
Cryo-EM structure of DNMT5 binary complex with hemimethylated DNA
分子名称: DNA (5'-D(P*GP*TP*CP*AP*GP*(5CM)P*GP*CP*AP*TP*GP*G)-3'), DNA repair protein Rad8, ZINC ION
著者Wang, J, Patel, D.J.
登録日2021-06-24
公開日2022-02-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
Mol.Cell, 82, 2022
7R78
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BU of 7r78 by Molmil
cryo-EM structure of DNMT5 quaternary complex with hemimethylated DNA, AMP-PNP and SAH
分子名称: DNA (5'-D(*TP*GP*CP*GP*CP*TP*GP*AP*CP*A)-3'), DNA (5'-D(P*CP*AP*GP*(5CM)P*GP*CP*AP*T)-3'), DNA repair protein Rad8, ...
著者Wang, J, Patel, D.J.
登録日2021-06-24
公開日2022-02-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
Mol.Cell, 82, 2022
7R76
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BU of 7r76 by Molmil
Cryo-EM structure of DNMT5 in apo state
分子名称: DNA repair protein Rad8, ZINC ION
著者Wang, J, Patel, D.J.
登録日2021-06-24
公開日2022-02-23
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insights into DNMT5-mediated ATP-dependent high-fidelity epigenome maintenance.
Mol.Cell, 82, 2022
8BAL
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BU of 8bal by Molmil
Niako3494, a bacterial protein structure in glycoside hydrolase family 20
分子名称: Beta-N-acetylhexosaminidase, ZINC ION
著者Dong, M.D, Roth, C.R, Jin, Y.J.
登録日2022-10-11
公開日2023-01-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 2022
8BDP
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BU of 8bdp by Molmil
A GH20 family sulfoglycosidase Bt4394 in complex with NAG-thiazoline and sulfite
分子名称: Beta-N-acetylhexosaminidase, CHLORIDE ION
著者Zhang, Z, He, Y, Jin, Y.
登録日2022-10-19
公開日2023-01-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 2022
8KER
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BU of 8ker by Molmil
Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535
分子名称: PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
著者Sun, L, Mao, Q, Wang, Y.
登録日2023-08-13
公開日2024-08-14
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (2.95 Å)
主引用文献Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8BBL
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BU of 8bbl by Molmil
SGL a GH20 family sulfoglycosidase
分子名称: Beta-N-acetylhexosaminidase
著者Dong, M.D, Roth, C.R, Jin, Y.J.
登録日2022-10-13
公開日2023-01-11
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.711 Å)
主引用文献Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases
Acs Catalysis, 2022
8KDT
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BU of 8kdt by Molmil
The local refined map of SARS-CoV Spike protein complexed with antibody PW5-5
分子名称: PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
著者Sun, L, Mao, Q, Wang, Y.
登録日2023-08-10
公開日2024-08-14
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.04 Å)
主引用文献Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KDS
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BU of 8kds by Molmil
Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535
分子名称: PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
著者Sun, L, Mao, Q, Wang, Y.
登録日2023-08-10
公開日2024-08-14
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KEP
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BU of 8kep by Molmil
The local refined map of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570
分子名称: PW5-570 heavy chain, PW5-570 light chain, Spike glycoprotein
著者Sun, L, Mao, Q, Wang, Y.
登録日2023-08-13
公開日2024-08-14
最終更新日2025-06-25
実験手法ELECTRON MICROSCOPY (2.93 Å)
主引用文献Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024
8KEK
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BU of 8kek by Molmil
Monomer state of SARS-CoV Spike protein complexed with antibody PW5-535
分子名称: PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
著者Sun, L, Mao, Q, Wang, Y.
登録日2023-08-11
公開日2024-08-14
最終更新日2025-07-02
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination.
Cell Discov, 10, 2024

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件を2025-07-16に公開中

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