5OJN
 
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3JY9
 | | Janus Kinase 2 Inhibitors | | 分子名称: | (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, Tyrosine-protein kinase JAK2 | | 著者 | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | | 登録日 | 2009-09-21 | | 公開日 | 2009-12-01 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole.
J.Med.Chem., 52, 2009
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8BBK
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6SNL
 | | (R)-selective amine transaminase from Exophiala sideris | | 分子名称: | CHLORIDE ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | | 著者 | Telzerow, A, Hakansson, M, Steiner, K. | | 登録日 | 2019-08-26 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (3.129 Å) | | 主引用文献 | Expanding the Toolbox of R-Selective Amine Transaminases by Identification and Characterization of New Members.
Chembiochem, 22, 2021
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2OY4
 | | Uninhibited human MMP-8 | | 分子名称: | CALCIUM ION, Neutrophil collagenase, ZINC ION | | 著者 | Calderone, V, Bertini, I, Fragai, M, Luchinat, C, Maletta, M, Yeo, K.J. | | 登録日 | 2007-02-21 | | 公開日 | 2007-03-06 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Snapshots of the reaction mechanism of matrix metalloproteinases.
ANGEW.CHEM.INT.ED.ENGL., 45, 2006
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7QYQ
 | | Crystal structure of a DyP-type peroxidase from Pseudomonas putida | | 分子名称: | Dyp-type peroxidase family protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Borges, P.T, Silva, D, Frazao, C, Martins, L.O. | | 登録日 | 2022-01-28 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.599 Å) | | 主引用文献 | Unveiling molecular details behind improved activity at neutral to alkaline pH of an engineered DyP-type peroxidase.
Comput Struct Biotechnol J, 20, 2022
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4G27
 | | Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and phenylurea | | 分子名称: | 1-phenylurea, CALCIUM ION, Calmodulin, ... | | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | | 登録日 | 2012-07-11 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
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7QZA
 | | Crystal structure of a DyP-type peroxidase 29E4 variant from Pseudomonas putida | | 分子名称: | Dyp-type peroxidase family protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Borges, P.T, Silva, D, Frazao, C, Martins, L.O. | | 登録日 | 2022-01-30 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.698 Å) | | 主引用文献 | Unveiling molecular details behind improved activity at neutral to alkaline pH of an engineered DyP-type peroxidase.
Comput Struct Biotechnol J, 20, 2022
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7QYZ
 | | Crystal structure of a DyP-type peroxidase 6E10 variant from Pseudomonas putida | | 分子名称: | Dyp-type peroxidase family protein, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Borges, P.T, Silva, D, Martins, L.O, Frazao, C. | | 登録日 | 2022-01-30 | | 公開日 | 2022-08-03 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (2.452 Å) | | 主引用文献 | Unveiling molecular details behind improved activity at neutral to alkaline pH of an engineered DyP-type peroxidase.
Comput Struct Biotechnol J, 20, 2022
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4G28
 | | Calcium-calmodulin complexed with the calmodulin binding domain from a small conductance potassium channel splice variant and EBIO-1 | | 分子名称: | 1-ethyl-1,3-dihydro-2H-benzimidazol-2-one, CALCIUM ION, Calmodulin, ... | | 著者 | Zhang, M, Pascal, J.M, Zhang, J.-F. | | 登録日 | 2012-07-11 | | 公開日 | 2012-09-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Identification of the functional binding pocket for compounds targeting small-conductance Ca(2+)-activated potassium channels.
Nat Commun, 3, 2012
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8G0G
 | | Crystal structure of diphtheria toxin H223Q/H257Q double mutant (pH 4.5) | | 分子名称: | ADENYLYL-3'-5'-PHOSPHO-URIDINE-3'-MONOPHOSPHATE, Diphtheria toxin | | 著者 | Lovell, S, Kashipathy, M.M, Battaile, K.P, Ladokhin, A.S. | | 登録日 | 2023-01-31 | | 公開日 | 2023-07-05 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Histidine Protonation and Conformational Switching in Diphtheria Toxin Translocation Domain.
Toxins, 15, 2023
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5NRY
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6OLU
 | | RIAM RA-PH core structure in the P212121 space group | | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | | 著者 | Wu, J. | | 登録日 | 2019-04-17 | | 公開日 | 2020-04-22 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM.
Structure, 29, 2021
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6O6H
 | | RIAM cc-RA-PH structure in the P21212 space group | | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | | 著者 | Wu, J. | | 登録日 | 2019-03-06 | | 公開日 | 2020-09-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM.
Structure, 2020
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5NRT
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5NS5
 | | Cys-Gly dipeptidase GliJ in complex with Cu2+ and Zn2+ | | 分子名称: | CHLORIDE ION, COPPER (II) ION, Dipeptidase gliJ, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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8G0F
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5NRX
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5NRZ
 | | Cys-Gly dipeptidase GliJ in complex with Mn2+ | | 分子名称: | CHLORIDE ION, Dipeptidase gliJ, GLYCEROL, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5NS2
 | | Cys-Gly dipeptidase GliJ in complex with Co2+ | | 分子名称: | CHLORIDE ION, COBALT (II) ION, Dipeptidase gliJ, ... | | 著者 | Groll, M, Huber, E.M. | | 登録日 | 2017-04-25 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Gliotoxin Biosynthesis: Structure, Mechanism, and Metal Promiscuity of Carboxypeptidase GliJ.
ACS Chem. Biol., 12, 2017
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5NS1
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5NRU
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4C4O
 | | Structure of carbonyl reductase CPCR2 from Candida parapsilosis in complex with NADH | | 分子名称: | 1,2-ETHANEDIOL, CARBONYL REDUCTASE CPCR2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | 著者 | Man, H, Loderer, C, Ansorge-Schumacher, M, Grogan, G. | | 登録日 | 2013-09-06 | | 公開日 | 2014-07-16 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structure of Nadh-Dependent Carbonyl Reductase (Cpcr2) from Candida Parapsilosis Provides Insight Into Mutations that Improve Catalytic Properties
Chemcatchem, 6, 2014
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3GMD
 | | Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I | | 分子名称: | 2-methyl-3-{(3S)-1-[(1-pyridin-2-ylcyclopropyl)carbonyl]pyrrolidin-3-yl}-1H-pyrrolo[2,3-b]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Valeur, E, Lepifre, F, Roche, D, Christmann-Franck, S, Hillertz, P, Musil, D. | | 登録日 | 2009-03-13 | | 公開日 | 2010-11-17 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | | 主引用文献 | Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I.
Bioorg.Med.Chem.Lett., 22, 2012
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4BUO
 | | High Resolution Structure of Thermostable Agonist-bound Neurotensin Receptor 1 Mutant without Lysozyme Fusion | | 分子名称: | GLYCINE, NEUROTENSIN RECEPTOR TYPE 1, NEUROTENSIN/NEUROMEDIN N | | 著者 | Egloff, P, Hillenbrand, M, Schlinkmann, K.M, Batyuk, A, Mittl, P, Plueckthun, A. | | 登録日 | 2013-06-21 | | 公開日 | 2014-01-29 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Proc.Natl.Acad.Sci.USA, 111, 2014
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