4MWD
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433) and ATP analog AMPPCP | 分子名称: | 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. | 登録日 | 2013-09-24 | 公開日 | 2014-04-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.253 Å) | 主引用文献 | Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
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8T49
| MD65 N332-GT5 SOSIP in complex with RM_N332_03 Fab and RM20A3 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2023-06-08 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates. Science, 384, 2024
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8SWW
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8SX3
| 10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10 | 分子名称: | 10E8 Fab heavy chain, 10E8 light chain, 10E8-GT10.2 immunogen, ... | 著者 | Huang, J, Ozorowski, G, Ward, A.B. | 登録日 | 2023-05-19 | 公開日 | 2024-05-22 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Vaccination induces broadly neutralizing antibody precursors to HIV gp41. Nat.Immunol., 25, 2024
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8T4B
| MD65 N332-GT5 SOSIP in complex with RM_N332_32 Fab and RM20A3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, MD65 N332-GT5 SOSIP gp41, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2023-06-08 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates. Science, 384, 2024
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8TB2
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8T4K
| MD64 N332-GT5 SOSIP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD64 N332-GT5 SOSIP gp120, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2023-06-09 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates. Science, 384, 2024
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8T4A
| MD65 N332-GT5 SOSIP in complex with RM_N332_36 Fab and RM20A3 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2023-06-08 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates. Science, 384, 2024
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8T4L
| MD65 N332-GT5 SOSIP in complex with RM_N332_07 Fab and RM20A3 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MD65 N332-GT5 SOSIP gp120, ... | 著者 | Ozorowski, G, Torres, J.L, Ward, A.B. | 登録日 | 2023-06-09 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates. Science, 384, 2024
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8SWV
| BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody IF1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IF1 Heavy Chain, ... | 著者 | Pratap, P.P, Antansijevic, A, Ozorowski, G, Ward, A.B. | 登録日 | 2023-05-19 | 公開日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Focusing antibody responses to the fusion peptide in rhesus macaques To Be Published
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8SW4
| BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 21M20 heavy chain variable region, ... | 著者 | Ozorowski, G, Torres, J.L, Zhang, S, Ward, A.B. | 登録日 | 2023-05-17 | 公開日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Neutralizing antibodies induced in non-human primates by germline targeting Env trimer To Be Published
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8SWX
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8T2F
| BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody N289 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N289 Heavy Chain, ... | 著者 | Pratap, P.P, Antansijevic, A, Ozorowski, G, Ward, A.B. | 登録日 | 2023-06-05 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Focusing antibody responses to the fusion peptide in rhesus macaques To Be Published
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8T2E
| BG505 Boost2 SOSIP.664 in complex with NHP polyclonal antibody FP3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FP3 Heavy Chain, ... | 著者 | Pratap, P.P, Antansijevic, A, Ozorowski, G, Ward, A.B. | 登録日 | 2023-06-05 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Focusing antibody responses to the fusion peptide in rhesus macaques To Be Published
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4MW4
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1473) | 分子名称: | 1-{3-[(5-chloro-2-hydroxy-3-iodobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. | 登録日 | 2013-09-24 | 公開日 | 2014-04-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
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4MVW
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea (Chem 1433) | 分子名称: | 1-{3-[(3,5-dichlorobenzyl)amino]propyl}-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. | 登録日 | 2013-09-24 | 公開日 | 2014-04-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | 主引用文献 | Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
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4MWE
| Trypanosoma brucei methionyl-tRNA synthetase in complex with inhibitor 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea (Chem 1475) | 分子名称: | 1-(3-{[5-chloro-3-(prop-2-en-1-yl)-2-(prop-2-en-1-yloxy)benzyl]amino}propyl)-3-thiophen-3-ylurea, DIMETHYL SULFOXIDE, GLYCEROL, ... | 著者 | Koh, C.Y, Kim, J.E, Wetzel, A.B, de van der Schueren, W.J, Shibata, S, Liu, J, Zhang, Z, Fan, E, Verlinde, C.L.M.J, Hol, W.G.J. | 登録日 | 2013-09-24 | 公開日 | 2014-04-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness. Plos Negl Trop Dis, 8, 2014
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4O3X
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4O3W
| Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Tyr-63-Ala from Actinobacillus suis H57 | 分子名称: | GLYCEROL, SULFATE ION, Transferrin binding protein B | 著者 | Calmettes, C, Yu, R.H, Schryvers, A.B, Moraes, T.F. | 登録日 | 2013-12-18 | 公開日 | 2015-01-14 | 最終更新日 | 2015-03-04 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect.Immun., 83, 2015
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4O4U
| Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Trp-176-Ala from Haemophilus parasuis Hp5 | 分子名称: | GLYCEROL, TbpB | 著者 | Calmettes, C, Yu, R.H, Schryvers, A.B, Moraes, T.F. | 登録日 | 2013-12-19 | 公開日 | 2015-01-14 | 最終更新日 | 2015-03-04 | 実験手法 | X-RAY DIFFRACTION (2.64 Å) | 主引用文献 | Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect.Immun., 83, 2015
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4O49
| Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Tyr-174-Ala from Actinobacillus pleuropneumoniae H87 | 分子名称: | ACETATE ION, GLYCEROL, Outer membrane protein; transferrin-binding protein | 著者 | Calmettes, C, Yu, R.H, Schryvers, A.B, Moraes, T.F. | 登録日 | 2013-12-18 | 公開日 | 2015-01-14 | 最終更新日 | 2015-03-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect.Immun., 83, 2015
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4OOI
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4OYQ
| (6-isothiocyanatohexyl)benzene inhibitor complexed with Macrophage Migration Inhibitory Factor | 分子名称: | 6-isothiocyanatohexylbenzene, GLYCEROL, Macrophage migration inhibitory factor, ... | 著者 | Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. | 登録日 | 2014-02-12 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | To be published To be published
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4OSF
| 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor | 分子名称: | CHLORIDE ION, ISOPROPYL ALCOHOL, Macrophage migration inhibitory factor, ... | 著者 | Spencer, E.S, Dale, E.J, Gommans, A.L, Vo, C.T, Rutledge, M.T, Nakatani, Y, Gamble, A.B, Smith, R.A.J, Wilbanks, S.M, Hampton, M.B, Tyndall, J.D.A. | 登録日 | 2014-02-12 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Multiple binding modes of isothiocyanates that inhibit macrophage migration inhibitory factor Eur.J.Med.Chem., 93, 2015
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8UGQ
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