4O4U

Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Trp-176-Ala from Haemophilus parasuis Hp5

Summary for 4O4U

• Entry DOI: 10.2210/pdb4o4u/pdb
• Related: 4O3W 4O3X 4O3Y 4O3Z 4O49 4O4X
• Descriptor: TbpB, GLYCEROL (3 entities in total)
• Functional Keywords: structure-based vaccine design, transferrin receptor, iron acquisition, host pathogen interaction, surface lipoprotein, metal transport
• Biological source: Haemophilus parasuis
• Total number of polymer chains: 4
• Total formula weight: 233642.85

Authors

Calmettes, C.,Yu, R.H.,Schryvers, A.B.,Moraes, T.F. (deposition date: 2013-12-19, release date: 2015-01-14, Last modification date: 2015-03-04)

• Primary citation: Frandoloso, R.,Martinez-Martinez, S.,Calmettes, C.,Fegan, J.,Costa, E.,Curran, D.,Yu, R.H.,Gutierrez-Martin, C.B.,Rodriguez-Ferri, E.F.,Moraes, T.F.,Schryvers, A.B.; Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities.; Infect.Immun., 83:1030-1038, 2015; PubMed: 25547790; DOI: 10.1128/IAI.02572-14

Experimental method

X-RAY DIFFRACTION (2.64 Å)