4O3X

Crystal structure of the vaccine antigen Transferrin Binding Protein B (TbpB) mutant Phe-171-Ala from Actinobacillus pleuropneumoniae H49

Summary for 4O3X

Entry DOI	10.2210/pdb4o3x/pdb
Related	4O3W 4O3Y 4O3Z 4O49 4O4U 4O4X
Descriptor	Transferrin binding protein B (2 entities in total)
Functional Keywords	structure-based vaccine design, transferrin receptor, iron acquisition, host pathogen interaction, surface lipoprotein, metal transport
Biological source	Actinobacillus pleuropneumoniae
Total number of polymer chains	1
Total formula weight	28025.89
Authors	Calmettes, C.,Yu, R.H.,Schryvers, A.B.,Moraes, T.F. (deposition date: 2013-12-18, release date: 2015-01-14, Last modification date: 2024-02-28)
Primary citation	Frandoloso, R.,Martinez-Martinez, S.,Calmettes, C.,Fegan, J.,Costa, E.,Curran, D.,Yu, R.H.,Gutierrez-Martin, C.B.,Rodriguez-Ferri, E.F.,Moraes, T.F.,Schryvers, A.B. Nonbinding site-directed mutants of transferrin binding protein B exhibit enhanced immunogenicity and protective capabilities. Infect.Immun., 83:1030-1038, 2015 Cited by PubMed: 25547790 DOI: 10.1128/IAI.02572-14 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation